Do antidepressants affect motivation in conditioned place preference?

Subhan, Fazal; Deslandes, Paul; Pache, David; Sewell, Robert David Edmund

doi:10.1016/s0014-2999(00)00771-8

Cited by 37 publications

(23 citation statements)

References 37 publications

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“…Collectively these results suggest that acute inhibition of the DRN via 5-HT 1A autoreceptors is rewarding, whereas stimulation of 5-HT 1A and 5-HT 1B heteroreceptors is aversive. This conclusion is consistent with pharmacological studies using acute administration of a serotonin-specific reuptake inhibitor or monoamine oxidase inhibitor to enhance 5-HT function, which rodents find aversive (Berendsen and Broekkamp, 1994; Buresova and Bures, 1987; Gommans et al , 1998; Prendergast et al , 1996) - but see (Olivier et al , 1999; Subhan et al , 2000). The idea of serotonin as an aversive signal has been further explored in “opponent process” theory (Boureau and Dayan, 2011; Cools et al , 2011; Daw et al , 2002).…”

Section: Influence Of 5-ht Autoreceptors On Behavior In Unstressedsupporting

confidence: 87%

Regulation of dorsal raphe nucleus function by serotonin autoreceptors: A behavioral perspective

McDevitt

Neumaier

2011

Journal of Chemical Neuroanatomy

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Neurotransmission by serotonin (5-HT) is tightly regulated by several autoreceptors that fine-tune serotonergic neurotransmission through negative feedback inhibition at the cell bodies (predominantly 5-HT1A) or at the axon terminals (predominantly 5-HT1B); however, more subtle roles for 5-HT1D and 5-HT2B autoreceptors have also been detected. This review provides an overview of 5-HT autoreceptors, focusing on their contribution in animal behavioral models of stress and emotion. Experiments targeting 5-HT autoreceptors in awake, behaving animals have generally shown that increasing autoreceptor feedback is anxiolytic and rewarding, while enhanced 5-HT function is aversive and anxiogenic; however, the role of serotonergic activity in behavioral models of helplessness is more complex. The prevailing model suggests that 5-HT autoreceptors become desensitized in response to stress exposure and antidepressant administration, two seemingly opposite manipulations. Thus there are still unresolved questions regarding the role of these receptors - and serotonin in general - in normal and pathological states.

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Section: Influence Of 5-ht Autoreceptors On Behavior In Unstressedsupporting

confidence: 87%

Regulation of dorsal raphe nucleus function by serotonin autoreceptors: A behavioral perspective

McDevitt

Neumaier

2011

Journal of Chemical Neuroanatomy

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“…Third, noradrenergic afferents to NAcc largely avoid the core (Delfs et al, 1998), where lesion effects on locomotor stimulation oc- jpet.aspetjournals.org curred. Fourth, stimulation of noradrenergic transmission did not produce CPP (Martin-Iverson et al, 1985;Subhan et al, 2000). Fifth, neither ␣-nor ␤-adrenergic receptor antagonists affected the rewarding effects of i.v.…”

Section: Discussionmentioning

confidence: 89%

Evidence for Multiple Sites within Rat Ventral Striatum Mediating Cocaine-Conditioned Place Preference and Locomotor Activation

Sellings

McQuade²,

Clarke

2006

J Pharmacol Exp Ther

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Considerable evidence suggests that psychostimulants can exert rewarding and locomotor-stimulating effects via increased dopamine transmission in the ventral striatum. However, the relative contributions of ventral striatal subregions to each of these effects have been little investigated. In the present study, we examined the contribution of different ventral striatal sites to the rewarding and locomotor-activating effects of cocaine. Initially, the effects of bilateral 6-hydroxydopamine lesions of the nucleus accumbens core or medial shell on cocaine-induced locomotor stimulation (0.5-1.5 mg/kg i.v. or 5-20 mg/kg i.p.) and conditioned place preference (0.5 mg/kg i.v. or 10 mg/kg i.p.) were examined. In a subsequent study, we investigated the effects of olfactory tubercle versus medial shell lesions on cocaine-conditioned place preference and locomotor activity (0.5 mg/kg i.v.). Dopaminergic lesion extent was quantified by radioligand binding to the dopamine transporter. Multiple linear regression was used to identify associations between behavioral effects and residual dopamine innervation in ventral striatal subregions.

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“…With the use of anhedonia, it will be possible to identify areas and mechanisms associated with the sensitization of brain reward pathways (Subhan, Deslandes, Pache, & Sewell, 2000), resulting from enhanced firing activity dopamine neurons within the ventral tegmental area (Sekine, Suzuki, Ramachandran, Blackburn, & Ashby, 2007) and dopamine neurotransmission in the striatum (Stein, 2008).…”

Section: Discussionmentioning

confidence: 99%

Short‐ and long‐term antidepressant effects of ketamine in a rat chronic unpredictable stress model

et al. 2017

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Do antidepressants affect motivation in conditioned place preference?

Cited by 37 publications

References 37 publications

Regulation of dorsal raphe nucleus function by serotonin autoreceptors: A behavioral perspective

Regulation of dorsal raphe nucleus function by serotonin autoreceptors: A behavioral perspective

Evidence for Multiple Sites within Rat Ventral Striatum Mediating Cocaine-Conditioned Place Preference and Locomotor Activation

Short‐ and long‐term antidepressant effects of ketamine in a rat chronic unpredictable stress model

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