Childhood violence exposure is a prevalent public health problem.
Understanding the lasting impact of violence requires an enhanced appreciation
for the complex effects of violence across behavioral, physiologic, and
molecular outcomes. This subject matched, cross-sectional study of 80 children
explored the impact of violence exposure across behavioral, physiologic, and
cellular outcomes. Externalizing behavior, diurnal cortisol rhythm, and telomere
length (TL) were examined in a community recruited cohort of Black youth. Given
evidence that genetic variation contributes to individual differences in
response to the environment, we further tested whether a polymorphism in the
oxytocin receptor gene (OXTR rs53576) moderated associations
between violence and youth outcomes. Exposure to violence was directly
associated with increased externalizing behavior, but no direct association of
violence was found with cortisol or TL. Oxytocin genotype, however, moderated
the association between violence and both cortisol and TL, suggesting that
pathways linked to oxytocin may contribute to individual differences in the
physiologic and molecular consequences of violence exposure. Sex differences
with OXTR in cortisol and TL outcomes were also detected. Taken together, these
findings suggest that there are complex pathways through which violence exposure
impacts children, and that these pathways differ by both genetic variation and
the sex of the child.