Do Children and Adolescents With Type 1 Diabetes Mellitus Have a Higher Frequency of Parietal Cell Antibodies Than Healthy Controls?

Fröhlich‐Reiterer, Elke; Huber, Julia; Katz, Hermann; Suppan, Elisabeth; Obermayer–Pietsch, Barbara; Deutschmann, Andrea; Demel, Ulrike; Acham-Roschitz, Birgit; Weinhandl, Gudrun; Ambros-Rudolph, Christina M.; Hauer, A.; Borkenstein, Martin

doi:10.1097/mpg.0b013e3181fedb2a

Cited by 20 publications

(45 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Additionally, typical PCA seem to develop later in life (second or third decade). It is possible that gastric autoimmunity in our patient cohort was discovered earlier using the ATP4AA than would be detected via the formerly used standard methods using both subunits of the gastric proton pump or the intrinsic factor as antigen [5,10,13]. However, the clinical significance of ATP4AA needs further investigation.…”

Section: Discussionmentioning

confidence: 95%

“…It is more common in patients with other autoimmune diseases, e.g. type 1 diabetes [5,12]. Thus far the determinants of gastric autoimmunity among type 1 diabetes individuals have not been firmly established.…”

Section: Introductionmentioning

confidence: 99%

“…Thus far the determinants of gastric autoimmunity among type 1 diabetes individuals have not been firmly established. Limited data exist concerning the presence of autoantibodies targeting parietal cells (PCA) in children and adolescents with type 1 diabetes, especially with regard to the possibility of concomitant Hp infection [5,10,13]. The prevalence of PCA has been reported to be between 9 and 21% in adults and 4 and 15% in children with type 1 diabetes [5,14].…”

Section: Introductionmentioning

confidence: 99%

“…Hp is an aetiological factor for chronic gastritis, duodenitis, peptic ulcer and a chronic infection that may lead to mucosa-associated lymphoid tissue (MALT) lymphoma and gastric cancer [2][3][4]. Moreover, some studies report that Hp may trigger an autoimmune response against the H+/K+ ATPase and be involved in the pathogenesis of autoimmune atrophic body gastritis (ABG) [5][6][7]. Present gastroenterological guidelines for the paediatric population suggest screening patients with gastric atrophy for Hp infection [8].…”

Section: Introductionmentioning

confidence: 99%

“…Limited data exist concerning the presence of autoantibodies targeting parietal cells (PCA) in children and adolescents with type 1 diabetes, especially with regard to the possibility of concomitant Hp infection [5,10,13]. The prevalence of PCA has been reported to be between 9 and 21% in adults and 4 and 15% in children with type 1 diabetes [5,14]. Most of these studies employed enzyme-linked immunosorbent or indirect immunofluorescence to detect the PCAs that are reactive to both ATPase subunits (4A and 4B) of the gastric proton pump.…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

ATP4A autoimmunity and Helicobacter pylori infection in children with type 1 diabetes

Chobot¹,

Wenzlau

Bąk-Drabik

et al. 2014

Clinical and Experimental Immunology

View full text Add to dashboard Cite

SummaryPersistent presence of ATP4A autoantibodies (ATP4AA) directed towards parietal cells is typical for atrophic body gastritis (ABG), an autoimmune disease associated with type 1 diabetes. We assessed whether Helicobacter pylori (Hp) infection might be associated with positivity for ATP4AA in children with type 1 diabetes. Sera were collected from 70 (38Ǩ) type 1 diabetes children [aged 13·2 ± 4·5 years, age at diagnosis 8·8 ± 4·3 years, diabetes duration 4·5 ± 3·8 years, mean HbA1c 7·8 ± 1·6% (62 ± 17·5 mmol/mol)] seen at the regional diabetes clinic in Katowice, Poland. Patients were tested concurrently for Hp infection by means of a 13C urea breath test. ATP4AA were measured using a novel radioimmunoprecipitation assay developed at the Barbara Davies Center for Childhood Diabetes, University of Colorado. ATP4AA were present in 21 [30%, 95% confidence interval (CI) = 19-41%] and Hp infection was detected in 23 (33%, 95% CI = 22-44%) children.There was no statistically significant association between ATP4AA presence and Hp status. ATP4AA presence was not associated with current age, age at type 1 diabetes diagnosis, diabetes duration or current HbA1c. ATP4AA were more prevalent in females [42% (26-58%)] than males [16% (3-28%)], P = 0·016. ATP4A are found in nearly one-third of children with type 1 diabetes and more common among females. In this cross-sectional analysis, Hp infection was not associated with autoimmunity against parietal cells.

show abstract

Section: Discussionmentioning

confidence: 95%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

ATP4A autoimmunity and Helicobacter pylori infection in children with type 1 diabetes

Chobot¹,

Wenzlau

Bąk-Drabik

et al. 2014

Clinical and Experimental Immunology

View full text Add to dashboard Cite

show abstract

Systemic Disease Affecting the Stomach

Protheroe

2017

Esophageal and Gastric Disorders in Infancy and Childhood

View full text Add to dashboard Cite

Komorbiditäten bei Typ-1-Diabetes im Kindes- und Jugendalter

Fröhlich‐Reiterer

2021

Monatsschr Kinderheilkd

View full text Add to dashboard Cite

ZusammenfassungTyp-1-Diabetes (T1D) ist eine der häufigsten Stoffwechselerkrankungen im Kindes- und Jugendalter. Komorbiditäten beim T1D können in physische und psychische unterteilt werden. Dieser Beitrag beschäftigt sich mit physischen/organspezifischen Komorbiditäten. Die Assoziation zwischen T1D und anderen Autoimmunerkrankungen ist gut bekannt. Die beiden häufigsten assoziierten Autoimmunerkrankungen bei Kindern und Jugendlichen mit T1D sind die Autoimmunthyreoiditis und die Zöliakie. Da diese oft asymptomatisch sind, sollen regelmäßige Screeninguntersuchungen auf eine assoziierte Autoimmunthyreoiditis und Zöliakie durchgeführt werden. Weitere Komorbiditäten können die Haut, das Gewicht und Längenwachstum sowie die Knochen und Gelenke betreffen. Regelmäßige Messungen von Körperlänge und -gewicht (Perzentilen), Blutdruck (Perzentilen), die Beurteilung der Pubertätsentwicklung (Tanner-Stadien) sowie die regelmäßige Überprüfung der Haut, hier v. a. die Injektions‑/Katheter- und Sensor-Stellen, sollen fixer Bestandteil der Langzeitbetreuung von Kindern und Jugendlichen mit T1D sein.

show abstract

Do Children and Adolescents With Type 1 Diabetes Mellitus Have a Higher Frequency of Parietal Cell Antibodies Than Healthy Controls?

Abstract: Children and adolescents with T1DM have a lower frequency of PCA than is reported for adults. Compared to healthy controls, they seem to be at increased risk for developing PCA, in particular if positive for TPOAb, but overt clinical disease is rare in children with T1DM.

Cited by 20 publications

References 29 publications

ATP4A autoimmunity and Helicobacter pylori infection in children with type 1 diabetes

ATP4A autoimmunity and Helicobacter pylori infection in children with type 1 diabetes

Systemic Disease Affecting the Stomach

Komorbiditäten bei Typ-1-Diabetes im Kindes- und Jugendalter

Contact Info

Product

Resources

About