Do DNA ploidy and S-phase fraction in primary tumour predict the response to chemotherapy in metastatic breast cancer?

Hietanen, Päivi; Blomqvist, Carl; Wasenius, Veli-Matti; Niskanen, Eero; Franssila, Kaarle; Nordling, Stig

doi:10.1038/bjc.1995.198

Cited by 40 publications

(25 citation statements)

References 24 publications

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“…Studies on breast cancer have shown that patients whose primary tumour has high proliferative activity respond better to CT (Remvikos et al, 1989;O'Reilly et al, 1992;Hietanen et al, 1995). Similar results have been obtained in a melanoma study (Karlsson et al, 1996).…”

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confidence: 75%

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A high proliferation rate measured by cyclin A predicts a favourable chemotherapy response in soft tissue sarcoma patients

et al. 1999

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A small but not insignificant number of patients experience a prolonged survival after treatment of metastatic soft tissue sarcoma. This must be weighed against the majority of the patients who benefit little from the therapy, but nevertheless experience its side-effects. It would therefore be of utmost importance to be able to screen for those patients who respond to the treatment. Since proliferating cells are more sensitive to chemotherapy than non-proliferative cells, we measured the proliferation rate of the primary tumour of 55 soft tissue sarcoma patients with locally advanced or metastatic disease by determining the flow cytometric S phase fraction and immunohistochemical Ki-67 and cyclin A scores. S phase fraction or Ki-67 score did not predict chemotherapy response or progression-free survival. A high cyclin A score, however, correlated with a better chemotherapy response ( P = 0.02) and longer progression-free survival time ( P = 0.04). Our results suggest that a high cyclin A score predicts chemotherapy sensitivity. © 1999 Cancer Research Campaign

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confidence: 75%

“…However, little is known about tumour-related factors which might predict CT response in STS. In several other tumours a high proliferation rate has been shown to be one of the factors increasing responsiveness to CT (Mattern et al, 1986;Remvikos et al, 1989;O'Reilly et al, 1992;Hietanen et al, 1995).…”

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A high proliferation rate measured by cyclin A predicts a favourable chemotherapy response in soft tissue sarcoma patients

et al. 1999

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“…The response to chemotherapy was significantly better in patients with tumours with a high SPF (Hietanen et al, 1995). Surprisingly, low-grade tumours responded better (Niskanen et al, 1997).…”

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“…Both ductal and lobular carcinomas were histologically graded by one pathologist (KF) according to the Richardson Bloom classification modified by Elston and Ellis (1991). The cutoff point for low and high SPF was 4.2% in diploid tumours and 12.5% in aneuploid tumours (Hietanen et al, 1995), which is the median of the respective groups in a large series of SPF determination in our laboratory. p53 immunohistochemical assays were performed using the D07 (Novocastra) antibody, and we interpreted the tumour as positive for p53 overexpression if > 10% of cells stained positively.…”

Section: Materials and Methods Patients And Tumour Materialsmentioning

confidence: 99%

“…We have previously published results on the value of DNA ploidy and SPF (Hietanen et al, 1995), histological grade, c-erbB-2, p53 and cathepsin-D (Niskanen et al, 1997), and Bcl-2 and Bax (Krajewski et al, 1995) to predict chemotherapy response in metastatic breast cancer. The response to chemotherapy was significantly better in patients with tumours with a high SPF (Hietanen et al, 1995).…”

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A multivariate analysis of tumour biological factors predicting response to cytotoxic treatment in advanced breast cancer

Sjöström

Krajewski²,

Franssila³

et al. 1998

Br J Cancer

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Summary The study was designed to identify factors that could predict response to chemotherapy in breast cancer. A total of 173 patients with measurable or evaluable metastatic breast cancer were enrolled in a randomized trial between November 1987 and January 1991 to receive a monthly dose of 5-fluorouracil (500 mg m-2), epirubicin (60 mg m-2) and cyclophosphamide (500 mg m-2) either administered in four weekly doses or in an every-4-week dose as first-line cytotoxic treatment. In 103 evaluable patients we performed a multivariate analysis of the tumour biological factors, i.e. histological grade, oestrogen receptor (ER), progesterone receptor (PR), S-phase fraction (SPF), ploidy, p53, c-erbB-2, Bcl-2 and Bax expression, which showed significance in the univariate analysis according to treatment response, time to progression (TTP) or overall survival (OS). In the univariate analysis only SPF, grade and the proapoptotic protein Bax correlated with the response to cytotoxic treatment. In the multivariate analysis SPF had the strongest correlation, followed by grade and Bax. In the univariate analysis grade, PR, Bax and Bcl-2 correlated significantly with TTP, whereas in the multivariate analysis only PR showed a statistically significant correlation. In the univariate analysis PR and Bax correlated with OS and both retained its significance in the multivariate analysis. The factors that correlated significantly with the response to cytotoxic treatment in the univariate analysis, i.e. grade, SPF and Bax, seemed to predict independently the response to treatment in the multivariate analysis also. UTP and OS could be predicted partly by the same factors, although the association was quite weak. More studies and new tumour biological factors are needed to identify the group of breast cancer patients who get the most benefit from chemotherapy.

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Comparison between ki-67 index and S-phase fraction on fine-needle aspiration samples from breast carcinoma

Bozzetti

Nizzoli

Camisa

et al. 1997

Cancer

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antibody Ki-67 and SPF determined by DNA flow cytometry. and SPF were evaluable in 114 and 107 cases, respectively, and 1 Divisione di Oncologia Medica, Ospedale di Parma, Parma, Italy. RESULTS.both were evaluable in 95 cases. Of the 134 FNA samples studied, 37% were diploid and 63% were aneuploid. The distribution of both Ki-67 and SPF was different in 2 Centro di Studio per l'Istochimica del CNR, diploid and aneuploid tumors. The median Ki-67 value as well as the median SPF

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Do DNA ploidy and S-phase fraction in primary tumour predict the response to chemotherapy in metastatic breast cancer?

Cited by 40 publications

References 24 publications

A high proliferation rate measured by cyclin A predicts a favourable chemotherapy response in soft tissue sarcoma patients

A high proliferation rate measured by cyclin A predicts a favourable chemotherapy response in soft tissue sarcoma patients

A multivariate analysis of tumour biological factors predicting response to cytotoxic treatment in advanced breast cancer

Comparison between ki-67 index and S-phase fraction on fine-needle aspiration samples from breast carcinoma

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