Do Healthy Potential Kidney Donors in India Have an Average Glomerular Filtration Rate of 81.4 ml/min?

Abstract

Background: Until now, a normal reference range for glomerular filtration rate (GFR) in adult Indian potential kidney donors has not been determined and values from a western population are being used as reference. Aim: To determine the reference range of GFR in healthy adult Indian potential kidney donors. Basic Procedures: GFR was measured in 610 (250 male, 360 female, average age 35.16 years) healthy potential kidney donors using the ^99mTc-DTPA (diethylenetriamine pentaacetic acid) two-plasma sample method of Russell. Results: The mean body surface area (BSA)-normalized GFR value of a young healthy Indian adult potential kidney donor was calculated as 81.4 ± 19.4 ml/min/1.73 m² BSA – for males it was 82.3 ± 21.3 ml/min/1.73 m² BSA and for females 80.8 ± 18.1 ml/min/1.73 m² BSA. There was no significant difference between derived mean GFR values in males and females with a p value of 0.37. Conclusions: The normal GFR value for the healthy Indian adult potential kidney donor appears to be much lower than the accepted value for a western population. The mean GFR value of a young healthy Indian adult potential kidney donor is 81.4 ± 19.4 ml/min/1.73 m² BSA, which is significantly different from the normal value of 109–125 ml/min derived from a western population. These findings might be useful in deciding on a suitable kidney donor in an Indian context.

Glomerular Filtration Rate in Healthy Living Potential Kidney Donors: A Meta-Analysis Supporting the Construction of the Full Age Spectrum Equation

“…Normal mGFR could be slightly lower in such Asian populations. Different hypotheses to explain such results are lower BSA in this population, low protein diet or different methods to measure GFR [1,32,42,43] . Also in this population, additional research seems necessary.…”

Assessing Renal Function Using Cockcroft-Gault and Modification of Diet in Renal Disease Equations in Healthy South Indian Males – A pilot study

“…21 Srinivas et al, evaluated the performance of serum creatinine based equations to estimate GFR in South Asian healthy renal donors and found that the mean GFR was 95.5±11.6 ml/min. 22 Our study too is comparable with earlier reports and the mean eGFR by CG and MDRD equations was found to be 91.05±15.04 and 86.43±13.61 respectively.…”

Effect of Age on Estimated Glomerular Filtration Rate

“…In their study, for men >60 years and women >50 years, GFR of 60 ml/min/1.73m 2 is within the normal reference range (12). In another study conducted by Barai et al, on potential kidney donors, it was found that no significant difference in the GFR between males and females in 20-30 or 30-40 year age groups, but significantly higher GFR was observed in females than in males in the age group of 41-45 years, suggesting slow or no progression in females with age (13) . Many authors have showed decline in GFR with age but without taking gender into consideration (1) .…”