Do Inhalational Anesthetic Agents Still Hold Their Place in Modern Anesthesia Practice?

Potočnik, Igor; Hostnik, Andrej; Božić, Jasmina

doi:10.22514/sv152.092019.1

Cited by 2 publications

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“…[30][31][32][33] VA modulate the inflammatory response and have a positive anti-inflammatory effect. 34,35 However, it is not clear whether this also has a negative effect on tumour cells. There are observations that they have a pro-inflammatory effect and therefore accelerate metastasis.…”

Section: The Effect Of Anaesthetics and Anaesthetic Technique On Infl...mentioning

confidence: 99%

The influence of anaesthesia on cancer growth

Potocnik,

Kerin-Povsic,

Markovic-Bozic

2024

Radiology and Oncology

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Background Oncological patients make up a large proportion of all surgical patients. Through its influence on the patient’s inflammatory and immune system, the choice of anaesthetic technique has an indirect impact on the health of the individual patient and on public health. Both the specific and the non-specific immune system have a major influence on the recurrence of carcinomas. The pathophysiological basis for growth and metastasis after surgery is the physiological response to stress. Inflammation is the organism’s universal response to stress. Anaesthetics and adjuvants influence perioperative inflammation in different ways and have an indirect effect on tumour growth and metastasis. In vitro studies have shown how individual anaesthetics influence the growth and spread of cancer, but clinical studies have not confirmed these results. Nevertheless, it is advisable to use an anaesthetic that has shown lesser effect on the growth of cancer cells in vitro. Conclusions In this review, we focus on the area of the effects of anaesthesia on tumour growth. The field is still relatively unexplored, there are only few clinical prospective studies and their results are controversial. Based on the review of new research findings we report on recommendations about anaesthetics and anaesthetic techniques that might be preferable for oncological surgical procedures.

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Section: The Effect Of Anaesthetics and Anaesthetic Technique On Infl...mentioning

confidence: 99%

The influence of anaesthesia on cancer growth

Potocnik,

Kerin-Povsic,

Markovic-Bozic

2024

Radiology and Oncology

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“…79 Anesthetic agents directly target neurons through intravenous injection or inhalation and can result in common side effects such as nausea, vomiting, hypotension, shivering, temporary confusion, interim memory loss, respiratory depression, and arrhythmia. 80 Improper administration can cause severe damage to the central nervous system, vital organs, or even death, making accurate handling with professional measures essential. Therefore, further research and improvements to develop targeted, sustained, and controlled release of general anesthetics with minimal side effects, easy resuscitation, and prevention of adverse reactions are imperative.…”

Section: General Anesthesia Nanomedicinesmentioning

confidence: 99%

Emerging Anesthetic Nanomedicines: Current State and Challenges

Zhang¹,

Wang²,

Zhang³

et al. 2023

IJN

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Anesthetics, which include both local and general varieties, are a unique class of drugs widely utilized in clinical surgery to alleviate pain and promote relaxation in patients. Although numerous anesthetics and their traditional formulations are available in the market, only a select few exhibit excellent anesthetic properties that meet clinical requirements. The main challenges are the potential toxic and adverse effects of anesthetics, as well as the presence of the blood-brain barrier (BBB), which makes it difficult for most general anesthetics to effectively penetrate to the brain. Loading anesthetics onto nanocarriers as anesthetic nanomedicines might address these challenges and improve anesthesia effectiveness, reduce toxic and adverse effects, while significantly enhance the efficiency of general anesthetics passing through the BBB. Consequently, anesthetic nanomedicines play a crucial role in the field of anesthesia. Despite their significance, research on anesthetic nanomedicines is still in its infancy, especially when compared to other types of nanomedicines in terms of depth and breadth. Although local anesthetic nanomedicines have received considerable attention and essentially meet clinical needs, there are few reported instances of nanomedicines for general anesthetics. Given the extensive usage of anesthetics and the many of them need for improved performance, emerging anesthetic nanomedicines face both unparalleled opportunities and considerable challenges in terms of theory and technology. Thus, a comprehensive summary with systematic analyses of anesthetic nanomedicines is urgently required. This review provides a comprehensive summary of the classification, properties, and research status of anesthetic nanomedicines, along with an exploration of their opportunities and challenges. In addition, future research directions and development prospects are discussed. It is hoped that researchers from diverse disciplines will collaborate to study anesthetic nanomedicines and develop them as a valuable anesthetic dosage form for clinical surgery.

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Do Inhalational Anesthetic Agents Still Hold Their Place in Modern Anesthesia Practice?

Cited by 2 publications

References 0 publications

The influence of anaesthesia on cancer growth

The influence of anaesthesia on cancer growth

Emerging Anesthetic Nanomedicines: Current State and Challenges

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