Do matrix metalloproteinases play a role in degenerative disease of temporomandibular joint? A systematic review

Expression of MMP-13 in human temporomandibular joint disc derangement and osteoarthritis

“…But the TMJ's disc is a fibrocartilage, different from other joints in the body (hyaline cartilage), and this disc is composed mostly of type 1 collagen rather than type 2, whereas hyaline cartilage has no type 1 collagen [5,10,13] . A balance between degradation of collagen fibers performed by matrix metalloproteinase (MMP) and their tissue inhibitor of metalloproteinase (TIMP), are responsible for functional remodeling of the TMJ [21,[26][27][28] .…”

“…MMPs have been reported to be involved in the cleavage of cell surface receptors and the release of apoptotic ligands (such as the Fas ligand). They play an important role in tissue remodeling associated with various physiological or pathological processes such as morphogenesis, angiogenesis, tissue repair, cirrhosis, arthritis, and metastasis [21,27,28] .…”

“…One of the most important metalloproteinases involved in degradation of collagen within the cartilage is MMP-13 (collagenase-3), a metalloproteinase of the collagenase group, which performs preferential digestion of type 2 collagen over type 1 and 3 collagens [26][27][28] . Leonardi et al [26] found correlation of an increased MMP-13 immunoreactivity in TMJ diseased disc tissue with the increased severity of the histopathological changes; however that study was performed with cadavers' discs.…”

“…Osteoarthrosis is characterized by deterioration and abrasion of articular cartilage. Some papers have demonstrated the association of MMPs (MMP-7, MMP-9, MMP-13) with osteoarthrosis, an inflammatory disorder of movable joints, in the degenerative process of joints included in the TMJ [21,27,28] .…”

“…Previous studies have shown that alteration of the disc structure may impact the expression of some mediators related to apoptosis and inflammatory process, and they could be associated with TMD progression [15][16][17][18][19][20][21][22][23][24][25][26] . The articular disc of the TMJ is formed basically by proteoglycan aggregates and collagen fibers that are composed mainly of type 1 and 2 collagen; its physiologic maintenance is through a balance between degradation of collagen fibers performed by matrix metalloproteinase (MMP) and their inhibitors, tissue inhibitor of matrix metalloproteinase (TIMP) [26][27][28] .…”