Do not miss secondary syphilis: examine the palms and soles

Hughes, Yasmin

doi:10.1136/bcr-2020-237725

Cited by 4 publications

(5 citation statements)

References 1 publication

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…As in the case of our patient and reported cases by Crouzy et al [ 7 ], the diagnosis of syphilis was made when 1 skin lesion was noticed in the palms and soles, thereby enhancing the importance of a systematic examination of the palms and soles [ 26 ]. Other mucocutaneous disorders can occur during secondary syphilis, including ulcerated plaques, painless and serpiginous lesions in the oral cavity, moth-eaten alopecia, which can be revealing, and condyloma lata [ 4 , 26 , 27 ]. These manifestations concern 25% of patients after 1 to 2 months of primary syphilis [ 26 ].…”

Section: Discussionmentioning

confidence: 58%

“…Mucocutaneous involvement is characteristic of secondary syphilis [ 3 , 4 ]. It is symptomized by a copper-red maculo-papular rash of variable size involving the trunk, extremities, and, most frequently, the palms and soles [ 4 , 25 , 26 ]. As in the case of our patient and reported cases by Crouzy et al [ 7 ], the diagnosis of syphilis was made when 1 skin lesion was noticed in the palms and soles, thereby enhancing the importance of a systematic examination of the palms and soles [ 26 ].…”

Section: Discussionmentioning

confidence: 99%

“…It is symptomized by a copper-red maculo-papular rash of variable size involving the trunk, extremities, and, most frequently, the palms and soles [ 4 , 25 , 26 ]. As in the case of our patient and reported cases by Crouzy et al [ 7 ], the diagnosis of syphilis was made when 1 skin lesion was noticed in the palms and soles, thereby enhancing the importance of a systematic examination of the palms and soles [ 26 ]. Other mucocutaneous disorders can occur during secondary syphilis, including ulcerated plaques, painless and serpiginous lesions in the oral cavity, moth-eaten alopecia, which can be revealing, and condyloma lata [ 4 , 26 , 27 ].…”

Section: Discussionmentioning

confidence: 99%

“…Other mucocutaneous disorders can occur during secondary syphilis, including ulcerated plaques, painless and serpiginous lesions in the oral cavity, moth-eaten alopecia, which can be revealing, and condyloma lata [ 4 , 26 , 27 ]. These manifestations concern 25% of patients after 1 to 2 months of primary syphilis [ 26 ]. With the current epidemic of syphilis, practitioners will likely encounter these manifestations [ 5 ].…”

Section: Discussionmentioning

confidence: 99%

See 3 more Smart Citations

Case of Secondary Syphilis with Mucocutaneous, Articular, and Pulmonary Involvement in a 74-Year-Old Moroccan Man

2022

View full text Add to dashboard Cite

Patient: Male, 74-year-old Final Diagnosis: Secondary syphilis Symptoms: Knee pain Medication:— Clinical Procedure: — Specialty: Rheumatology Objective: Challenging differential diagnosis Background: Syphilis is a sexually transmitted infection (STI) caused by Treponema pallidum . If untreated, primary syphilis can progress to secondary syphilis, which has a characteristic rash and diverse systemic features. This report is of a case of secondary syphilis with mucocutaneous, articular, and pulmonary involvement. Case Report: A 74-year-old Moroccan man presented with an 8-week history of bilateral knee pain and swelling. On examination, he had bilateral knee effusions. Articular puncture brought an inflammatory fluid with a significant presence of white blood cells. Inflammatory markers were elevated. X-rays of both knees showed bilateral osteoarthritis with intra-articular calcification in the left knee. Nonsteroidal anti-inflammatory drugs and colchicine were prescribed, but were ineffective. A closer clinical examination of the patient revealed pigmented papules on the palms, soles, oral mucosa, trunk, and genitals. Treponema pallidum hemagglutination assay and Venereal Disease Research Laboratory results were positive in the blood (titers 1: 32) and joint fluid. A computed tomography scan of the chest revealed a focal opacity in the lateral basal segment of the right lung. The diagnosis of secondary syphilis with mucocutaneous, articular, and pulmonary involvement was made. The evolution was favorable after a single intramuscular injection of benzathine-penicillin. Conclusions: Arthritis, mucocutaneous involvement, and lung lesions can be manifestations of secondary syphilis. A detailed anamnesis, clinical examination, serology, and imaging techniques are the pillars of diagnosing this condition.

show abstract

Section: Discussionmentioning

confidence: 58%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Case of Secondary Syphilis with Mucocutaneous, Articular, and Pulmonary Involvement in a 74-Year-Old Moroccan Man

2022

View full text Add to dashboard Cite

show abstract

“…17 Keterlibatan telapak tangan dan telapak kaki merupakan salah satu ciri khas ruam pada sifilis sekunder, yaitu keratoderma makulopapular, papuloskuamosa, atau hiperkeratosis palmoplantar. 5,18 Bercak progresif pada telapak tangan dan kaki dengan keterlibatan wajah, ekstremitas, selaput lendir harus dicurigai sebagai sifilis sekunder. 19 Temuan dermatologis dari sifilis sekunder bervariasi dan dapat menyerupai lupus kulit.…”

Section: Anti-sm 4 Antibodi Antifosfolipidunclassified

Sifilis Menyerupai Lupus Eritematosus: The Great Imitator

Budianti,

Sarah

2024

J. Kdokt Meditek

View full text Add to dashboard Cite

Manifestasi klinis yang terlihat pada sifilis sering menyerupai penyakit inflamasi kronis seperti lupus eritematosus. Sebuah studi menyatakan angka kejadian misdiagnosis sifilis dengan lupus eritematosus sebanyak 166 kasus sepanjang tahun 2006-2011. Seorang laki-laki 24 tahun datang dengan lesi oral, bercak merah pada kedua telapak tangan dan kaki disertai telogen efluvium, madarosis, artralgia, dan nyeri otot. Pasien telah didiagnosis Lupus Eritematosus Sistemik (LES) dengan keterlibatan mukokutan dan muskuloskeletal berdasarkan klinis dan serologis kemudian dirawat oleh sejawat Internis dengan obat imunosupresan selama 3 minggu tetapi keluhan bertambah parah. Pasien kemudian dirujuk ke dokter dermatologi dan venereologi untuk pengobatan bercak pada telapak tangan dan kaki. Hasil pemeriksaan mengarah pada sifilis sekunder dan didukung hasil serologi. Pasien mendapatkan injeksi benzathine penicillin 2,4 juta IU intramuskular dan klinis membaik dalam satu minggu. Tujuan laporan kasus ini untuk meningkatkan kewaspadaan terhadap diagnosis sifilis yang merupakan the great imitator yang memiliki tampilan klinis dan serologis menyerupai penyakit autoimun.

show abstract