Do patients with Down syndrome develop appendicitis?

Lewis, Muriel; Gauderer, Michael W.L.; Blackhurst, Dawn W.; Rogers, R. Curtis; Cornett, Wendy R.

doi:10.1016/j.jpedsurg.2010.09.086

Cited by 1 publication

(1 citation statement)

References 9 publications

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“…However, there is no general incidence rate known, and within the context of gastrointestinal surgery there appears to be less sepsis in Down syndrome . Appendicitis seems to be less common in Down syndrome . Individuals with Down syndrome who are institutionalized are more likely to be hepatitis B carriers; however, this has not been studied since the 1980s nor in the context of non‐institutionalized individuals with Down syndrome .…”

Section: Introductionmentioning

confidence: 99%

Clinical implications of immune‐mediated diseases in children with Down syndrome

Verstegen

Chang

Kusters

2019

Pediatric Allergy Immunology

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Children with Down syndrome have changes in their innate and adaptive immunity, which contribute to increased rates of infections, autoimmune diseases, and haematological malignancies. While improved care for congenital heart disease has decreased mortality and morbidity, complications related to immune‐mediated diseases continue to limit the life expectancy in Down syndrome. Infectious diseases are common and have a significant effect on development, behaviour and quality of life. Infection frequency and severity are influenced by various anatomical and physiological alterations in addition to immunological changes in Down syndrome. Thus, prevention of respiratory tract infections requires a multifactorial approach. This could include additional active and/or passive immunizations, prophylactic antibiotics, immunoglobulin replacement and ear, nose and throat surgical interventions. Autoimmune conditions like coeliac disease, type I diabetes mellitus and thyroid disease are classically mentioned in the context of Down syndrome. However, autoinflammatory conditions are more prevalent as well. Screening for autoimmune diseases is required and immunosuppression has to be used with caution. Future studies should address optimal screening programmes for immune‐mediated diseases in individuals with Down syndrome, as well as the effect of immune modulation, to further decrease morbidity and mortality, and improve the quality of life of individuals with Down syndrome.

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Section: Introductionmentioning

confidence: 99%