Do schizophrenia patients with low P50-suppression report more perceptual anomalies with the sensory gating inventory?

Micoulaud-Franchi, Jean-Arthur; Hetrick, William P.; Aramaki, Mitsuko; Bolbecker, Amanda R.; Boyer, Laurent; Ystad, Sølvi; Kronland‐Martinet, Richard; Richieri, Raphaëlle; Faget, Catherine; Faugere, Mélanie; El-Kaim, Alexandre; Cermolacce, M.; Lançon, Christophe; Vion‐Dury, Jean

doi:10.1016/j.schres.2014.05.013

Cited by 27 publications

(18 citation statements)

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“…It objectifies the perceptual abnormalities and functional and psychosocial consequences of sensory gating. SGI could confirm anomalies of sensory gating and perceptual inundation in schizophrenia (Micoulaud-Franchi and Vion-Dury, 2013;Micoulaud-Franchi et al, 2014;El-Kaim et al, 2015), attention-deficit hyperactivity disorder (ADHD) (Sable et al, 2012;Micoulaud-Franchi et al, 2014; and Tourette syndrome (Sutherland Owens et al, 2011).…”

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confidence: 99%

Toward An Exploration of Habituating to Tinnitus: Perspectives on Sensory Gating

et al. 2019

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Some tinnitus participants habituate to their tinnitus, but some others do not and complain of its annoyance so much. It has been suggested that tinnitus is a habituation deficit. Habituation and the ability to ignore a sensory input depend on the normal function of filtering mechanism of sensory gating.The purpose of this study was to compare behavioral aspects of sensory gating in normal and tinnitus participants to search for the reason why some tinnitus participants habituate to their tinnitus but some others do not.This investigation was an observational case–control study.There were 60 tinnitus participants who were categorized into two tinnitus groups (30 compensated tinnitus participants and 30 decompensated tinnitus participants) based on the complaint of tinnitus annoyance, visual analog scale (VAS) for tinnitus loudness, annoyance, and awareness, scores on Tinnitus Questionnaire (TQ), and Tinnitus Handicap Inventory (THI). Also, there were 30 normal hearing participants without tinnitus as the normal control group.Sensory Gating Inventory (SGI), TQ, THI, and VAS was obtained from all participants. THI, TQ, VAS, and SGI total scores and their factors were compared among the groups. Correlations between SGI scores with THI, TQ, and VAS score were calculated.The results showed that SGI total score and the scores of its four factors were significantly higher in decompensated tinnitus participants compared with compensated tinnitus participants and normal controls. Also, there was a positive correlation between SGI perceptual modulation factor and TQ emotional distress factor and with the VAS for loudness in decompensated tinnitus group.These results suggested that tinnitus associated with behavioral aspects of sensory gating and decompensated tinnitus may be a result of deficient sensory gating.

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Toward An Exploration of Habituating to Tinnitus: Perspectives on Sensory Gating

et al. 2019

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“…9 In a conditioning-testing P50 procedure described previously in the study of Micoulaud-Franchi et al, 11 the P50 amplitude was measured in response to an auditory-paired click stimulus: S1 (conditioning stimulus) and S2 (testing stimulus). The P50 component is a middle-latency positive event-related potential component occurring approximately 50 milliseconds after the onset of a brief auditory stimulus.…”

Section: Sensory Gating Measuresmentioning

confidence: 99%

“…9 Sensory gating deficit has been confirmed repeatedly in schizophrenia. 11 Patients with high sensory gating deficit report the perception of being inundated and overwhelmed by external sensory stimuli. 11 Patients with high sensory gating deficit report the perception of being inundated and overwhelmed by external sensory stimuli.…”

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“…10 Recently, it was found that sensory gating deficit is related to perceptual abnormalities in schizophrenia. 11,12 Although perceptual abnormalities are now known as core symptoms of schizophrenia, 13,14 only a few studies investigated the effects of second-generation antipsychotics on these abnormalities. 11,12 Although perceptual abnormalities are now known as core symptoms of schizophrenia, 13,14 only a few studies investigated the effects of second-generation antipsychotics on these abnormalities.…”

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Effects of Clozapine on Perceptual Abnormalities and Sensory Gating

Micoulaud-Franchi¹,

Aramaki²,

Geoffroy³

et al. 2015

Journal of Clinical Psychopharmacology

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The aim of the present study was to investigate the effect of second-generation antipsychotics (clozapine or another second-generation antipsychotic) on perceptual abnormalities related to sensory gating deficit. Although clozapine is known to improve sensory gating assessed neurophysiologically, we hypothesized that patients with schizophrenia treated with clozapine would report less perceptual abnormalities related to sensory gating deficit than patients treated with other second-generation antipsychotics do. Forty patients with a diagnosis of schizophrenia were investigated (10 patients treated with clozapine and 30 patients treated with another second-generation antipsychotic drug). Perceptual abnormalities were assessed with the Sensory Gating Inventory. Sensory gating was assessed through electroencephalogram with the auditory event-related potential method by measuring P50 amplitude changes in a dual click conditioning-testing procedure. Patients treated with clozapine present normal sensory gating and report less perceptual abnormalities related to sensory gating than patients treated with other second-generation antipsychotics do. Although the cross-sectional design of this study is limited because causal inferences cannot be clearly concluded, the present study suggests clinical and neurophysiological advantages of clozapine compared with other second-generation antipsychotics and provides a basis for future investigations on the effect of this treatment on perceptual abnormalities related to sensory gating deficit in patients with schizophrenia.

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“…There are several studies that show a correlation between schizophrenia and the alteration of visual perception (such as visual masking, Green et al, 2012, luminance, size, contrast, orientation and motion perception, Yang et al, 2013; Serrano-Pedraza et al, 2014), as well as eye movements (Silverstein and Keane, 2011). However, vision is not the only sense affected in schizophrenia: aberrant processing of auditory (Micoulaud-Franchi et al, 2014), olfactory (Moberg et al, 2014), gustative (Compton et al, 2013) and tactile (Ferri et al, 2014) stimuli also occurs. These are important discoveries for improving our understanding of schizophrenia.…”

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confidence: 99%