2020
DOI: 10.1007/s10072-020-04909-1
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Do serum GDNF levels correlate with severity of Alzheimer’s disease?

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Cited by 22 publications
(12 citation statements)
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“…An increase of ApoE can lower the Aβ 40-42 turnover rate on greater cognitive decline in AD [57]. The same has also been found to negatively influence or disturb autophagy by disrupting autophagosome formation [59]. This, in turn, leads to greater deterioration of neuronal health in AD pathology.…”
Section: Roles Of Cytokines In Autophagymentioning
confidence: 97%
“…An increase of ApoE can lower the Aβ 40-42 turnover rate on greater cognitive decline in AD [57]. The same has also been found to negatively influence or disturb autophagy by disrupting autophagosome formation [59]. This, in turn, leads to greater deterioration of neuronal health in AD pathology.…”
Section: Roles Of Cytokines In Autophagymentioning
confidence: 97%
“…The effects of GDNF on neuronal atrophy, a condition associated with cognitive decline in old age, were investigated in another study. The levels of GDNF on cognitive functions in the form of spatial learning and memory abilities showed significant changes in cognitive abilities in old age [ 17 ]. Decreased GDNF levels induce deregulation of the glutamate transporter, causing excitotoxicity in the nervous system resulting in dopaminergic degeneration [ 11 ].…”
Section: Discussionmentioning
confidence: 99%
“…GDNF facilitates hippocampal neural progenitors and induces neurogenesis in the dentate gyrus. GDNF-mediated hippocampal neurogenesis contributed to the rescue of the cognitive impairment, an enhanced functionality of the antioxidant mechanisms protecting from the oxidative stress also against cognitive deficit [ 17 ]. Multiple pathways of GDNF neuroprotection are in involved GDNF signaling and survival pathways [ 12 ].…”
Section: Discussionmentioning
confidence: 99%
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“…But it has to be noted that others did not observe significant differences in the GDNF levels in the plasma of AD patients and control groups [ 136 ]. Nevertheless, a growing body of evidence suggests that GDNF levels are probably involved in the pathogenesis and progression of AD, suggesting that its blood levels could potentially be used as an AD biomarker [ 137 ].…”
Section: Neurotrophic Factors At the Interface Of Ad Pathophysiology And Neural Arhlmentioning
confidence: 99%