Do specific pockets of HLA-C molecules predispose Jewish patients to psoriasis vulgaris?

Roitberg-Tambur, Anat; Friedmann, Adam; Tzfoni, Eli; Battat, S.; Hammo, Rivka Ben; Safirman, C.; Tokunaga, Katsushi; Asahina, Akihiko; Brautbar, Chaim

doi:10.1016/s0190-9622(94)70265-9

Cited by 39 publications

(55 citation statements)

References 21 publications

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“…Recently, in a study conducted in Israeli Jewish patients, Roitberg-Tambur et al [23] again observed an alanine re sidue at position 73 of the first extracellular domain of HLA-C in all patients investigated. Some of these patients were typed as either Cw4, Cw6, Cw7 and Cwl2.…”

Section: Im M Unogeneticsmentioning

confidence: 85%

The Immunopathology of Psoriasis

Christophers

1996

Int Arch Allergy Immunol

126

101

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Psoriasis affects approximately 2% of the population in Western countries. Although clinically rather monomorphic, the disease presents with a number of phenotypically distinct and heterogeneous subgroups showing differences in their pathogenetic pathways. Patients with type I (early onset) psoriasis demonstrate inflammatory lesions with epidermal hyperproliferation and the presence of activated T cells as well as intraepidermal polymorphs as principal features. In contrast to pustular types of psoriasis, these patients show genetic susceptibility and strong association with MHC class I and class-I haplotypes. There is evidence for a T-cell-mediated pathomechanism leading to a large spectrum of regulatory mediators including cytokines and growth factors as well as lipid mediators which are abnormally expressed. Pathogenetically psoriasis shows features in common with chronic relapsing T-cell-mediated diseases including Crohn’s disease, rheumatoid arthritis and others.

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Section: Im M Unogeneticsmentioning

confidence: 85%

The Immunopathology of Psoriasis

Christophers

1996

Int Arch Allergy Immunol

126

101

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“…In addition, specific sequences of the HLA-C molecule confer a significant risk for developing psoriasis [1,7,12].…”

Section: Introductionmentioning

confidence: 99%

HLA risk haplotype Cw6,DR7, DQA1*0201 and HLA-Cw6 with reference to the clinical picture of psoriasis vulgaris

Ikäheimo¹,

Tiilikainen²,

Karvonen³

et al. 1996

Arch Dermatol Res

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Psoriasis vulgaris has HLA associations. We have previously defined HLA-Cw6,DR7,DQA1*0201 as the central element of the risk haplotypes for psoriasis. On the other hand, Cw6 as a single gene has the strongest association with psoriasis. The aim of this study was to determine whether the risk haplotype and Cw6 correlate with the clinical parameters of the disease. The series consisted of 64 patients and the clinical parameters were age at onset, family history of psoriasis, arthritis and the frequency of inpatient treatment. The HLA risk haplotype Cw6,DR7,DQA1*0201 had previously been found in 30% and Cw6 alone in 54% of the patients. The presence of Cw6 correlated with early age at onset (Pc = 0.01). The presence of the risk haplotype correlated with a positive family history of psoriasis among the first-degree relatives (Pc = 0.02) and an overall positive family history (Pc = 0.04), but Cw6 had a stronger correlation with an overall positive family history (Pc = 0.01). There were no positive correlations with arthritis or the number of inpatient treatment periods. Only type I psoriasis was associated with Cw6 (Pc = 0.0006). In conclusion, Cw6 and the haplotype Cw6,DR7,DQA1*0201 are important in the heredity of psoriasis vulgaris, but the presence of Cw6 alone is sufficient to indicate a clinically significant risk for psoriasis.

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“…The association between psoriasis and HLAs has been reported in several ethnic groups [1][2][3]. The strongest association was with CW6 [6][7][8][9].…”

Section: Resultsmentioning

confidence: 99%

“…HLA-A1, B17, BW56, CW6 and DR7 were increased in psoriatic Indians [5,13], while in Japanese CW4, CW7 and CW11 were reported to be associated with the disease [7,12]. In Jewish patients, a significantly increased frequency of HLA-CW6 and CW7 was observed [3], whereas an increase in B17, CW6 and DR6 was reported in Italian infantile psoriatics [14].…”

Section: Resultsmentioning

confidence: 99%

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Association of Major Histocompatibility Complex with Psoriasis vulgaris in Adult Kuwaitis

Mahmoud

Abul²,

El-Naby

et al. 1998

Med Princ Pract

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Objective: The association of the major histocompatibility complex (MHC) with psoriasis vulgaris has been reported in different ethnic groups. However, an identification of human leukocyte antigen (HLA) genes that determine susceptibility to the disease has not been reported previously among the Arabs of the Arabian Peninsula. This study was conducted with the objective of establishing any correlation between psoriasis and the expression of HLA class I and class II in a Kuwaiti population. Methods: Expression frequencies of the MHC were measured in 26 Kuwaiti patients with psoriasis, and 60 control individuals were matched for age, sex and ethnic background. Tissue typing for class I and class II antigens was carried out by lymphocytotoxicity assays. Results: HLA-CW6, DQ2 and DQ7 were significantly increased in patients compared to controls (p = 0.0002, 0.0044 and 0.0004, respectively), while HLA-B7, DR5 and DR52 were significantly decreased (p = 0.002, 0.0004, 0.019, respectively). Conclusion: These findings suggest that psoriasis is associated with HLA-CW6, DQ2 and DQ7 in the Kuwaiti population. Further studies to investigate the association of distinct HLA with psoriasis vulgaris based on the RNA levels are under way.

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Do specific pockets of HLA-C molecules predispose Jewish patients to psoriasis vulgaris?

Cited by 39 publications

References 21 publications

The Immunopathology of Psoriasis

The Immunopathology of Psoriasis

HLA risk haplotype Cw6,DR7, DQA1*0201 and HLA-Cw6 with reference to the clinical picture of psoriasis vulgaris

Association of Major Histocompatibility Complex with Psoriasis vulgaris in Adult Kuwaitis

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