Do subjects with aggressive and chronic periodontitis exhibit a different cytokine/chemokine profile in the gingival crevicular fluid? A systematic review

Duarte, Poliana Mendes; Bastos, Marta Ferreira; Fermiano, Daiane; Rabelo, Cleverton Corrêa; Pérez-Chaparro, Paula Juliana; Figueiredo, Lígia; Faveri, Marcelo; Feres, Magda

doi:10.1111/jre.12180

Cited by 50 publications

(45 citation statements)

References 35 publications

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“…27,29,54 It is known that the quality of the host immuneinflammatory response against bacterial challenge determines the severity and extent of disease. 56,57 CP and G-AgP are different disease entities with different etiology and pathogenesis. 58 Although the initiation of the disease may differ a similar immunopathogenesis in both diseases have been suggested.…”

Section: Discussionmentioning

confidence: 99%

Gingival crevicular fluid interleukin-36β (-1F8), interleukin-36γ (-1F9) and interleukin-33 (-1F11) levels in different periodontal disease

Kursunlu

Öztürk

Han

et al. 2015

Archives of Oral Biology

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Section: Discussionmentioning

confidence: 99%

Gingival crevicular fluid interleukin-36β (-1F8), interleukin-36γ (-1F9) and interleukin-33 (-1F11) levels in different periodontal disease

Kursunlu

Öztürk

Han

et al. 2015

Archives of Oral Biology

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“…However, it is important to highlight that other recent studies have questioned a real difference between the chronic and aggressive forms of periodontitis (Van der Velden, ). A recent systematic review examined the profile of cytokines in the gingival crevicular fluid and concluded that the current weight of evidence is not sufficient to prove a difference between AP and CP (Duarte et al, ). Moreover, a microbiological study on bacterial screening of Aggregatibacter actinomycetemcomitans and Porphyromonas gingivalis in individuals with CP or AP concluded that the detection of these known periodontopathogenic bacterias is not able to discriminate different forms of periodontitis (Nibali et al, ).…”

Section: Discussionmentioning

confidence: 99%

Comparison of miRNA expression profiles in individuals with chronic or aggressive periodontitis

et al. 2018

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Objectives MicroRNAs (miRNAs) may play an important role in inflammatory response. However, the involvement of miRNAs in the pathogenesis of periodontitis is unclear. The present study aimed to compare the miRNA expression profiles in individuals with chronic (CP) or aggressive (AP) periodontitis. Materials and methods Eighteen non‐smoker individuals (CP = 9 and AP = 9) without any history of systemic diseases or previous periodontal therapies were selected at the Clinics of Periodontology from the Federal University of Minas Gerais. Gingival tissue samples were collected during the initial periodontal therapy. miRNAs were isolated, and expression patterns of 754 miRNAs were assessed with a quantitative miRNA PCR array. miRNAs expression profiles were compared between CP and AP groups. Results There were no differences observed in the miRNAs expression profiles between CP and AP (p > 0.05). According to the microarray analyses, the most expressed miRNAs in both groups were hsa‐miR‐1274b, hsa‐let‐7b‐5p, hsa‐miR‐24‐3p, hsa‐miR‐19b‐3p, hsa‐miR‐720, hsa‐miR‐126‐3p, hsa‐miR‐17‐3p and hsa‐miR‐21‐3p. Conclusion Findings suggested no differences in miRNAs expression profiles between chronic and aggressive forms of periodontitis. The overexpression of specific miRNAs could provide insights into the pathogenesis of both forms of the disease.

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“…No adverse effect was observed. 39 For the present study, MMP-1 and MMP-9 were chosen as two inflammatory mediators actively involved in the connective tissue remodelling process. 21 The cost-effectiveness of such structured plaque control intervention was previously reported.…”

Section: Manual Brush (N = 16)mentioning

confidence: 99%

Effect of sonic versus manual supervised toothbrushing on both clinical and biochemical profiles of patients with desquamative gingivitis associated with oral lichen planus: A randomized controlled trial

Bianco

Romano

Maggiora

et al. 2018

Int J Dental Hygiene

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Objectives The aim of this randomized, parallel‐design, clinical trial was to investigate the effectiveness of an intensive plaque control programme with sonic versus manual toothbrushing on clinical outcomes and gingival crevicular fluid (GCF) levels of matrix metalloproteinases (MMP) in desquamative gingivitis (DG) patients. Methods A total of 32 patients affected by DG secondary to oral lichen planus (OLP) were consecutively recruited and randomly assigned to a test (n = 16) and control (n = 16) group. Both groups were enrolled in an intensive control programme comprising supragingival scaling and polishing, and brush‐specific instructions for a period of 8 weeks. The treatment of interest (test) was the use of a sonic‐powered toothbrush, and the standard treatment (control) was the utilization of a soft‐bristle manual toothbrush for twice‐daily home oral hygiene procedures. Periodontal parameters, patient‐centred outcomes, MMP‐1 and MMP‐9 GCF levels were evaluated at baseline and 8 weeks after starting the programme. Results The plaque control programme resulted in statistically significant reduction in periodontal parameters with consequent improvement in the clinical features, painful symptoms and severity of DG lesions in both groups (all P < 0.001). When a sonic toothbrush was used, there was a more significant decrease in clinical indices, mucosal disease scores and GCF levels of MMP‐1 and MMP‐9. Conclusions This clinical trial reported the effectiveness of a combined protocol based on professional oral hygiene and supervised toothbrushing in OLP patients with DG. The daily use of a sonic toothbrush would seem to perform better in the short term.

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Do subjects with aggressive and chronic periodontitis exhibit a different cytokine/chemokine profile in the gingival crevicular fluid? A systematic review

Abstract: The current weight of evidence is not sufficient to prove that there are distinct gingival crevicular fluid cytokine/chemokine profiles for patients with aggressive periodontitis and chronic periodontitis.

Cited by 50 publications

References 35 publications

Gingival crevicular fluid interleukin-36β (-1F8), interleukin-36γ (-1F9) and interleukin-33 (-1F11) levels in different periodontal disease

Gingival crevicular fluid interleukin-36β (-1F8), interleukin-36γ (-1F9) and interleukin-33 (-1F11) levels in different periodontal disease

Comparison of miRNA expression profiles in individuals with chronic or aggressive periodontitis

Effect of sonic versus manual supervised toothbrushing on both clinical and biochemical profiles of patients with desquamative gingivitis associated with oral lichen planus: A randomized controlled trial

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