Do Thyroid-Stimulating Hormone, Body Weight, or Body Mass Index Serve as Adequate Markers to Guide Levothyroxine Dose Titration?

Levothyroxine Sodium Pentahydrate Tablets – Formulation Considerations

“…11,[51][52][53][54][55][56][57][58][59][60][61][62][63][64][65] Exceeding 20−25% of the therapeutic dose can result in serious side effects, warranting dose titration. [66][67][68][69][70][71][72][73][74] The need for precise dose adjustment has resulted in numerous strengths (>10) ranging from 13 to 500 mg. 75,76 The therapeutic failure may also stem from the chemical instability of the API in drug products and content non-uniformity − reflected by the numerous product recalls. [77][78][79][80] Thus, in addition to being one of the most prescribed drugs, levothyroxine sodium has a long history of being amongst the most recalled products from the market.…”

The role of infrared thermography (IRT) and magnetic resonance imaging (MRI) in brown fat evaluation and their application to study the effect of thyroid status on brown fat activity and white fat partitioning

“…It is also worthwhile as a sub-study to decipher if other circulating biomarkers of euthyroidism and BAT exist. In this regard, TSH has remained the only yardstick of thyroid status and it is debatable if TSH defines euthyroidism well where discrepancies between clinical and biochemical definition exist (Hoermann et al, 2013;Dietrich et al, 2013).…”