Do trifluralin and tebuthiuron impair isolated rat liver mitochondria?

Oliveira, Bárbara de; Pereira, Lílian Cristina; Pazin, Murilo; Franco-Bernanrdes, Mariana Furio; Dorta, Daniel Junqueira

doi:10.1016/j.pestbp.2019.11.012

Cited by 17 publications

(18 citation statements)

References 56 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Other pyrethroid pesticides also exhibit pro-oxidative properties in the liver, as shown in Table 3 [367][368][369][370][371], and various organophosphorus and organochlorine insecticides cause oxidative stress in animal liver [136,183,371,372]. Furthermore, several studies have reported the pro-oxidative properties of some herbicides [151,153,154,221,[373][374][375][376] and chemical families of fungicides (carbamate, benzimidazole, strobilurin, azoles, triazoles [159,[377][378][379][380][381][382][383]) (Table 3). Liver oxidative stress is also reported in animals exposed to a mixture of pesticides [168,193,384] (Tables 1 and 3).…”

Section: Oxidative Stress In Nafld: Role Of Pesticidesmentioning

confidence: 99%

Oxidative Stress in NAFLD: Role of Nutrients and Food Contaminants

et al. 2020

View full text Add to dashboard Cite

Non-alcoholic fatty liver disease (NAFLD) is often the hepatic expression of metabolic syndrome and its comorbidities that comprise, among others, obesity and insulin-resistance. NAFLD involves a large spectrum of clinical conditions. These range from steatosis, a benign liver disorder characterized by the accumulation of fat in hepatocytes, to non-alcoholic steatohepatitis (NASH), which is characterized by inflammation, hepatocyte damage, and liver fibrosis. NASH can further progress to cirrhosis and hepatocellular carcinoma. The etiology of NAFLD involves both genetic and environmental factors, including an unhealthy lifestyle. Of note, unhealthy eating is clearly associated with NAFLD development and progression to NASH. Both macronutrients (sugars, lipids, proteins) and micronutrients (vitamins, phytoingredients, antioxidants) affect NAFLD pathogenesis. Furthermore, some evidence indicates disruption of metabolic homeostasis by food contaminants, some of which are risk factor candidates in NAFLD. At the molecular level, several models have been proposed for the pathogenesis of NAFLD. Most importantly, oxidative stress and mitochondrial damage have been reported to be causative in NAFLD initiation and progression. The aim of this review is to provide an overview of the contribution of nutrients and food contaminants, especially pesticides, to oxidative stress and how they may influence NAFLD pathogenesis.

show abstract

Section: Oxidative Stress In Nafld: Role Of Pesticidesmentioning

confidence: 99%

Oxidative Stress in NAFLD: Role of Nutrients and Food Contaminants

et al. 2020

View full text Add to dashboard Cite

show abstract

“…It is possible that mitochondrial dysfunction caused by calcium ion dysregulation is the cause of the pathway analysis-suggested perturbation of the TCA cycle in D. rerio, which takes place in the mitochondrial membrane. Trifluralin has been shown to alter calcium levels (de Oliveira et al 2020) and mitochondrial membrane integrity in rat hepatocytes (Hertel et al 1981;de Oliveira et al 2020). Upstream regulator analysis suggested that the expression patterns observed in D. rerio resembled those due to inhibition of Ca 2+ , calcitriol effects, and zinc finger ccch-type containing 10 (ZC3H10).…”

Section: Discussionmentioning

confidence: 99%

Cross‐Taxa Distinctions in Mechanisms of Developmental Effects for Aquatic Species Exposed to Trifluralin

Awkerman

Lavelle

Henderson

et al. 2020

Enviro Toxic and Chemistry

View full text Add to dashboard Cite

Standard ecological risk assessment practices often rely on larval and juvenile fish toxicity data as representative of the amphibian aquatic phase. Empirical evidence suggests that endpoints measured in fish early life stage tests are often sufficient to protect larval amphibians. However, the process of amphibian metamorphosis relies on endocrine cues that affect development and morphological restructuring and are not represented by these test endpoints. The present study compares developmental endpoints for zebrafish (Danio rerio) and the African clawed frog (Xenopus laevis), 2 standard test species, exposed to the herbicide trifluralin throughout the larval period. Danio rerio were more sensitive and demonstrated a reduction in growth measurements with increasing trifluralin exposure. Size of X. laevis at metamorphosis was not correlated with exposure concentration; however, time to metamorphosis was delayed relative to trifluralin concentration. Gene expression patterns indicate discrepancies in response by D. rerio and X. laevis, and dose‐dependent metabolic activity suggests that trifluralin exposure perturbed biological pathways differently within the 2 species. Although many metabolites were correlated with exposure concentration in D. rerio, nontargeted hepatic metabolomics identified a subset of metabolites that exhibited a nonmonotonic response to trifluralin exposure in X. laevis. Linking taxonomic distinctions in cellular‐level response with ecologically relevant endpoints will refine assumptions used in interspecies extrapolation of standard test effects and improve assessment of sublethal impacts on amphibian populations. Environ Toxicol Chem 2020;39:1797–1812. Published 2020. This article is a US government work and is in the public domain in the USA.

show abstract

“…In studies using complex systems (field-scale or soil microcosms), it can be difficult to determine whether losses of trifluralin are due to volatilization, immobilization, abiotic degradation, or biotic degradation, since interpretation of the data depends on what type of controls were included, what type of analytical chemistry approach was used, and what experimental conditions were chosen (e.g., temperature, humidity, aeration, soil type). 22 The use of 14 C-labeledtrifluralin has been a very useful adjunct to HPLC or GC analysis, since this enables determination of the overall fate of herbicide derivatives, even if these cannot be effectively extracted into a solvent or separated by chromatography. Trifluralin with a 14 CF 3 label was used in one early study 43 to show that after an 83 day incubation, 8−10% of trifluralin was lost to volatilisation, 1.4−3.1% was mineralized to 14 CO 2 , 10− 70% was immobilized as bound residues, and the remainder was converted to dealkylated and cyclized derivatives.…”

Section: In Soilmentioning

confidence: 99%

“…22 The use of 14 C-labeledtrifluralin has been a very useful adjunct to HPLC or GC analysis, since this enables determination of the overall fate of herbicide derivatives, even if these cannot be effectively extracted into a solvent or separated by chromatography. Trifluralin with a 14 CF 3 label was used in one early study 43 to show that after an 83 day incubation, 8−10% of trifluralin was lost to volatilisation, 1.4−3.1% was mineralized to 14 CO 2 , 10− 70% was immobilized as bound residues, and the remainder was converted to dealkylated and cyclized derivatives. A later study using uniformly ring-labeled 14 C trifluralin 44 came to similar conclusions on mineralization, showing only 1.2−3.2% conversion to 14 CO 2 after 113 days, with rate constants for degradation of 0.004−0.03 days −1 .…”

Section: In Soilmentioning

confidence: 99%

“…Trifluralin is also herbicidal to commercial crops and native plants, and it has toxic effects on microfauna and macrofauna, most notably on fish, where lethal doses are as low as 50 μg/L . Early animal studies suggested trifluralin was not carcinogenic or teratogenic and that it had low toxicity, but later studies have shown that trifluralin can impact mitochondrial function, it has hormonal activity, , and it associates with higher cancer incidence rates in exposed agricultural workers . Trifluralin was ranked in the top five most hazardous pesticides of public health concern in a recent U.S.-specific study, and it has been banned in the European Union (EU) since 2008 due to concerns over its toxicity .…”

Section: Introduction: Chemistry Usage and Toxicity Of Trifluralinmentioning

confidence: 99%

See 1 more Smart Citation