2007
DOI: 10.1111/j.1462-5822.2007.00912.x
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Do type 1 fimbriae promote inflammation in the human urinary tract?

Abstract: SummaryType 1 fimbriae have been implicated as virulence factors in animal models of urinary tract infection (UTI), but the function in human disease remains unclear. This study used a human challenge model to examine if type 1 fimbriae trigger inflammation in the urinary tract. The asymptomatic bacteriuria strain Escherichia coli 83972, which fails to express type 1 fimbriae, due to a 4.25 kb fimB-fimD deletion, was reconstituted with a functional fim gene cluster and fimbrial expression was monitored through… Show more

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Cited by 50 publications
(46 citation statements)
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“…UPEC triggers the secretion of epithelial cytokines and chemokines that contribute to inflammation and pathology. For example, IL-6 levels in the urine correlate with disease severity, and IL-8 results in recruitment of neutrophils to the site of infection (86)(87)(88). Despite equivalent adherence to epithelial cells, E. coli CFT073 triggered a significantly stronger IL-6 cytokine response than E. coli VR50.…”
Section: Discussionmentioning
confidence: 99%
“…UPEC triggers the secretion of epithelial cytokines and chemokines that contribute to inflammation and pathology. For example, IL-6 levels in the urine correlate with disease severity, and IL-8 results in recruitment of neutrophils to the site of infection (86)(87)(88). Despite equivalent adherence to epithelial cells, E. coli CFT073 triggered a significantly stronger IL-6 cytokine response than E. coli VR50.…”
Section: Discussionmentioning
confidence: 99%
“…UPEC induces host cell apoptosis in cystitis patients (19)(20)(21) and macrophage inflammatory peptide 2 that is induced in response to neutrophils attracted to the bladder to counteract colonization by the bacterium (6). Specific UPEC adhesins, including type 1 and P fimbriae, trigger some of these processes (22,23). Host responses that arbitrate these very early steps in the pathogenesis of UPEC UTI are largely unknown, and the overall contributions of innate immune elements beyond previously identified mechanisms of attachment are not well defined.…”
mentioning
confidence: 99%
“…Deletion of cueO does not affect type 1 fimbria expression, adhesive capacity, or growth in urine. Expression of type 1 fimbriae significantly enhances the attachment of UPEC to uroepithelial cells and the subsequent colonization of the mouse bladder (2,4,20). We compared the levels of type 1 fimbria expression in CFT073 and in CFT073cueO by using a combination of standard techniques.…”
mentioning
confidence: 99%