Do very preterm twins and singletons differ in their neurodevelopment at 5 years of age?

Bodeau-Livinec, Florence; Zeitlin, Jennifer; Blondel, Béatrice; Arnaud, Catherine; Fresson, Jeanne; Burguet, A.; Damien, Subtil; Marret, Stéphane; Rozé, Jean‐Christophe; Marchand-Martin, Laetitia; Ancel, Pierre‐Yves; Kaminski, Monique

doi:10.1136/archdischild-2013-303737

Cited by 44 publications

(40 citation statements)

References 41 publications

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“…Similarly, sensorimotor performance of some of IH-mice did not differ from that of their naïve counterparts. These results are in agreement with clinical epidemiological data which demonstrate that not all, but~10-15% of VLBW prematurely born children develop cerebral palsy, and 25-50% children exhibit mild sensorimotor, cognitive and behavioral deficit (Bodeau-Livinec et al, 2013;Schlapbach et al, 2012;Volpe et al, 2011). The extent of sensorimotor deficit did not significantly correlate with the degree of hypomyelination (MBP cerebral expression) in IH-mice.…”

Section: Discussionsupporting

confidence: 94%

Mild intermittent hypoxemia in neonatal mice causes permanent neurofunctional deficit and white matter hypomyelination

Juliano

Sosunov

Niatsetskaya

et al. 2015

Experimental Neurology

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Section: Discussionsupporting

confidence: 94%

Mild intermittent hypoxemia in neonatal mice causes permanent neurofunctional deficit and white matter hypomyelination

Juliano

Sosunov

Niatsetskaya

et al. 2015

Experimental Neurology

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“…Manuck et al (2014) utilized the Bayley Scale of Infant Development (BSID) and Mental Development Index (MDI), and cerebral palsy was assessed by a pediatric neurologist (Manuck et al, 2014). Bodeau-Livinec et al (2013) utilized the Kaufmann Assessment Battery for Children for cognitive assessment, and cerebral palsy was also assessed, while Gnanendran et al (2015) utilized the BSID and Griffiths Mental Development Scales. Hjern et al (2012) utilized test scores from the 'Enlistment Battery 80' , used for military conscription at 18-19 years of age to create an indicator of IQ and grade point averages from the national school register, while Eras et al (2013) utilized the BSID, MDI, and Psychomotor Developmental Index (PDI).…”

Section: Methodsmentioning

confidence: 99%

Neurodevelopmental Outcomes of Twins Compared With Singleton Children: A Systematic Review

et al. 2018

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More than 200 million children aged <5 years fail to reach their full cognitive potential, and children born as twins are particularly at risk. In this article, we review studies that examined differences in the neurodevelopmental outcomes of twins compared to singletons. We searched the Medline database for articles on twins, singletons, neuro, and cognitive development. We also inspected bibliographies of relevant publications to identify related articles from 2011 to 2017. Our search criteria yielded 162 studies, 8 of which met the inclusion criteria. Of the eight studies examined, four were prospective follow-up studies, three were cross-sectional studies, and one was a randomized controlled trial. Five of these studies were carried out in developed countries, and they found no statistically significant difference in neurodevelopmental outcomes among twins and singletons. However, two of the three studies carried out in developing countries found a difference with singletons having significantly higher academic ratings than twins. Studies in which neurodevelopmental outcomes were measured early in life (1-5 years) showed no significant twin-singleton differences, while those in which it was measured later in life showed mixed twin-singleton differences. Overall, these studies may have been underpowered and may not have been optimally designed and implemented. There is need for studies with adequate sample sizes, good design, and optimal measurement of all relevant covariates in order to resolve the conflicting reports in the literature.

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“…Most research on multiples either does not distinguish between triplets and twins or focuses only on twins and there is a lack of data on the outcomes and care of very preterm triplet deliveries. Triplet pregnancies are rare, with a median of 0.3 per 1000 pregnancies in Europe in 2010, and these births are often excluded from analyses of very preterm births because there are too few cases in any given sample.…”

Section: Introductionmentioning

confidence: 99%

Characteristics, management and outcomes of very preterm triplets in 19 European regions

Dudenhausen

Misselwitz²,

Piedvache

et al. 2019

Intl J Gynecology & Obste

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Objective To describe obstetrical care and in‐hospital outcomes in very preterm triplet pregnancies in a European multiregional cohort. Methods Data from a prospective population‐based study of very preterm births between 22 + 0 and 31 + 6 weeks of gestation in 19 regions from 11 European countries participating in the EPICE project in 2011/2012 were used to describe triplet pregnancies and compare them with twins and singletons. Results Triplets constituted 1.1% of very preterm pregnancies (97/8851) and 3.3% of very preterm live births (258/7900); these percentages varied from 0% to 2.6% and 0% to 6% respectively across the regions. In‐hospital mortality after live birth was 12.4% and did not differ significantly from singletons or twins or by birth order. However, 28.9% of mothers with a triplet pregnancy experienced at least one neonatal death. Ninety percent of live‐born triplets were delivered by cesarean. Vaginal delivery was associated with an Apgar score of less than 7, but not with in‐hospital mortality. Conclusions The prevalence of very preterm triplets varies across European regions. Most triplets were born by cesarean and those born vaginally had lower Apgar scores. Overall, in‐hospital mortality after live birth was similar to singletons and twins.

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Do very preterm twins and singletons differ in their neurodevelopment at 5 years of age?

Abstract: Compared with very preterm singletons, twins had higher mortality, no difference with respect to severe deficiencies, but slightly lower MPC scores at 5 years.

Cited by 44 publications

References 41 publications

Mild intermittent hypoxemia in neonatal mice causes permanent neurofunctional deficit and white matter hypomyelination

Mild intermittent hypoxemia in neonatal mice causes permanent neurofunctional deficit and white matter hypomyelination

Neurodevelopmental Outcomes of Twins Compared With Singleton Children: A Systematic Review

Characteristics, management and outcomes of very preterm triplets in 19 European regions

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