Do we miss rare adverse events induced by COVID-19 vaccination?

Afshar, Zeinab Mohseni; Pirzaman, Ali Tavakoli; Liang, Jackson J.; Sharma, Akanksha; Pirzadeh, Marzieh; Babazadeh, Arefeh; Hashemi, Erfan; Deravi, Niloofar; Abdi, Sadaf; Allahgholipour, Amirreza; Hosseinzadeh, Rezvan; Vaziri, Zahra; Sio, Terence T.; Sullman, Mark J.M.; Barary, Mohammad; Ebrahimpour, Soheil

doi:10.3389/fmed.2022.933914

Cited by 15 publications

(15 citation statements)

References 228 publications

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“…Neurological complications have been reported as rare adverse reactions to COVID-19 vaccines [ 39 ] in the context of the immune response to vaccines. These complications include Guillain–Barré syndrome, an acute severe acquired immune-mediated inflammatory polyradiculoneuropathy that affects peripheral nerves.…”

Section: Discussionmentioning

confidence: 99%

“…Although the pathogenic mechanism is not fully understood, it has been associated with several infectious agents including SARS-CoV-2. A number of cases with this syndrome have also been reported following COVID-19 vaccination [ 39 ]. Given that spike proteins bind to gangliosides [ 40 ], cross-reacting anti-spike antibodies generated by vaccines could be involved in the onset of Guillain–Barré syndrome.…”

Section: Discussionmentioning

confidence: 99%

“…Given that spike proteins bind to gangliosides [ 40 ], cross-reacting anti-spike antibodies generated by vaccines could be involved in the onset of Guillain–Barré syndrome. Other neurological reactions such as palsies have been hypothesized to be related to the disruption of immunological tolerance to myelin sheath antigen induced by vaccines [ 39 ]. Fifty percent of cases of neurological complications in the present study showed type IV hypersensitivity to excipients, suggesting that it could be considered as another immune-mediated mechanism playing a role in the pathogenesis of these adverse reactions.…”

Section: Discussionmentioning

confidence: 99%

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Immune-Mediated Organ-Specific Reactions to COVID-19 Vaccines: A Retrospective Descriptive Study

Ruiz-Fernández,

Cuesta,

Martín-López

et al. 2023

Pharmaceuticals

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Severe acute respiratory syndrome coronavirus 2 caused the global COVID-19 pandemic and public health crisis, and it led to the rapid development of COVID-19 vaccines, which can cause rare and typically mild hypersensitivity reactions (HRs). Delayed HRs to COVID-19 vaccines have been reported, and the excipients polyethylene glycol (PEG)2000 and polysorbate 80 (P80) are the suspected culprits. Skin patch tests do not help in diagnosing delayed reactions. We aimed to perform lymphocyte transformation tests (LTT) with PEG2000 and P80 in 23 patients with suspected delayed HRs. Neurological reactions (n = 10) and myopericarditis reactions (n = 6) were the most frequent complications. Seventy-eight percent (18/23) of the study patients were admitted to a hospital ward, and the median time to discharge was 5.5 (IQR, 3–8) days. Some 73.9% of the patients returned to baseline condition after 25 (IQR, 3–80) days. LTT was positive in 8/23 patients (5/10 neurological reactions, 2/4 hepatitis reactions and 1/2 rheumatologic reactions). All myopericarditis cases had a negative LTT. These preliminary results indicate that LTT with PEGs and polysorbates is a useful tool for identifying excipients as causal agents in HRs to COVID-19 vaccines and can play an important role in risk stratification in patients with HRs.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Immune-Mediated Organ-Specific Reactions to COVID-19 Vaccines: A Retrospective Descriptive Study

Ruiz-Fernández,

Cuesta,

Martín-López

et al. 2023

Pharmaceuticals

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“…These types of adverse events are uncommon and warrant additional evaluation [ 26 ]. Autoimmune complications reported to occur with the COVID-19 vaccine include acquired hemophilia A, immune-mediated thrombocytopenia (ITP), anaphylaxis, capillary leak syndrome, cutaneous vasculitis, IgA vasculitis, thyroiditis, IgA nephropathy, acute macular neuroretinopathy, bilateral retinal detachment, uveitis, and pulmonary thromboembolism [ 27 ]. Further investigation is necessary to establish a cause-and-effect relationship as there is currently no substantial evidence suggesting that COVID-19 vaccination is primarily responsible.…”

Section: Discussionmentioning

confidence: 99%

Role of Psychosomatic Symptoms in COVID-19 Vaccine Hesitancy

et al. 2023

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Vaccination against COVID-19 is one of the highly effective preventative strategies to reduce morbidity and mortality associated with COVID-19 infection. The rapid approval of COVID-19 vaccination due to the raging pandemic, media coverage, anti-vaccination groups, and concerns about adverse effects associated with vaccination has given rise to COVID-19 vaccine hesitancy. Current evidence suggests that psychosomatic and nocebo-related adverse effects account for a significant proportion of common adverse effects following COVID-19 vaccination. The most common adverse effects are headache, fatigue, and myalgia, which are highly prone to nocebo effects. In our review article, we discuss the role of psychosomatic and nocebo effects in COVID-19 vaccination-related hesitancy, predictors of such effects, and strategies to reduce vaccine hesitancy. General education regarding psychosomatic and nocebo effects and specialized education for at-risk populations may reduce psychosomatic and nocebo-related adverse effects following COVID-19 vaccination, ultimately reducing hesitancy.

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“…There is increasing evidence that SARS-CoV-2 vaccinations of any brand can be complicated by mild or severe and short or long-lasting adverse reactions [ 1 ]. In most cases, these side effects are mild and short-lived.…”

Section: Introductionmentioning

confidence: 99%

A Case Report: Long Post-COVID Vaccination Syndrome During the Eleven Months After the Third Moderna Dose

Finsterer¹

2022

Cureus

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It is undisputed that anti-SARS-CoV-2 vaccines can have side effects. Long post-COVID vaccination syndrome (LPCVS) is one of them and is often neglected. It persists 11 months after the third mRNA-1273 (Moderna) vaccine dose has not been reported. Our patient is a 39-year-old male with a largely uneventful previous history who developed severe adverse reactions immediately after the third dose of the mRNA-1273 (Moderna) vaccine. In addition to brief fever, headache, flickering eyes, skin rashes, tiredness, disorientation, dizziness (brain fog), tiredness, impaired thinking and concentration, and emotional disorders occurred as a result. Cerebral MRI showed non-specific white matter lesions in a frontotemporal distribution. Some of the immune parameters were deflected. Non-steroidal anti-inflammatory drugs, antihistamines, sartans, and statins have occasionally provided temporary relief. In conclusion, LPCVS is a definite complication of anti-SARS-CoV-2 vaccinations and can severely impact the quality of life and lead to disability. Despite extensive work-up, a clear cause for the long-term neuro-cognitive deficits cannot be identified. Symptomatic treatment can provide some relief. Patients with LPCVS should be taken seriously and treated appropriately.

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Do we miss rare adverse events induced by COVID-19 vaccination?

Cited by 15 publications

References 228 publications

Immune-Mediated Organ-Specific Reactions to COVID-19 Vaccines: A Retrospective Descriptive Study

Immune-Mediated Organ-Specific Reactions to COVID-19 Vaccines: A Retrospective Descriptive Study

Role of Psychosomatic Symptoms in COVID-19 Vaccine Hesitancy

A Case Report: Long Post-COVID Vaccination Syndrome During the Eleven Months After the Third Moderna Dose

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