Do we need new treatments for type 2 diabetes?

Gómez-Peralta, Fernando; Padín, Cristina Abreu

doi:10.1016/j.endoen.2014.06.002

Cited by 7 publications

(4 citation statements)

References 35 publications

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“…Given the increased incidence of T2DM ( Khan et al, 2020 ) and the failure of current drugs to control the multiple pathophysiological processes in the long term, it is necessary to move forward in the search for novel medications that provide better solutions for the multiple abnormal targets and pathways of this disease ( Gomez-Peralta and Abreu Padín, 2014 ). Plants reported in traditional medicine to possess antidiabetic activity provide an interesting and wealthy resource to find new drugs in their hugely diverse compounds.…”

Section: Introductionmentioning

confidence: 99%

Integrating experimental model, LC-MS/MS chemical analysis, and systems biology approach to investigate the possible antidiabetic effect and mechanisms of Matricaria aurea (Golden Chamomile) in type 2 diabetes mellitus

et al. 2022

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Type 2 diabetes mellitus (T2DM) is a heterogeneous disease with numerous abnormal targets and pathways involved in insulin resistance, low-grade inflammation, oxidative stress, beta cell dysfunction, and epigenetic factors. Botanical drugs provide a large chemical space that can modify various targets simultaneously. Matricaria aurea (MA, golden chamomile) is a widely used herb in Middle Eastern communities for many ailments, including diabetes mellitus, without any scientific basis to support this tradition. For the first time, this study aimed to investigate the possible antidiabetic activity of MA in a type 2 diabetic rat model, identify chemical constituents by LC-MS/MS, and then elucidate the molecular mechanism(s) using enzyme activity assays, q-RTPCR gene expression analysis, network pharmacology analysis, and molecular docking simulation. Our results demonstrated that only the polar hydroethanolic extract of MA had remarkable antidiabetic activity. Furthermore, it improved dyslipidemia, insulin resistance status, ALT, and AST levels. LC-MS/MS analysis of MA hydroethanolic extract identified 62 compounds, including the popular chamomile flavonoids apigenin and luteolin, other flavonoids and their glycosides, coumarin derivatives, and phenolic acids. Based on pharmacokinetic screening and literature, 46 compounds were chosen for subsequent network analysis, which linked to 364 candidate T2DM targets from various databases and literature. The network analysis identified 123 hub proteins, including insulin signaling and metabolic proteins: IRS1, IRS2, PIK3R1, AKT1, AKT2, MAPK1, MAPK3, and PCK1, inflammatory proteins: TNF and IL1B, antioxidant enzymes: CAT and SOD, and others. Subsequent filtering identified 40 crucial core targets (major hubs) of MA in T2DM treatment. Functional enrichment analyses of the candidate targets revealed that MA targets were mainly involved in the inflammatory module, energy-sensing/endocrine/metabolic module, and oxidative stress module. q-RTPCR gene expression analysis showed that MA hydroethanolic extract was able to significantly upregulate PIK3R1 and downregulate IL1B, PCK1, and MIR29A. Moreover, the activity of the antioxidant hub enzymes was substantially increased. Molecular docking scores were also consistent with the networks’ predictions. Based on experimental and computational analysis, this study revealed for the first time that MA exerted antidiabetic action via simultaneous modulation of multiple targets and pathways, including inflammatory pathways, energy-sensing/endocrine/metabolic pathways, and oxidative stress pathways.

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Section: Introductionmentioning

confidence: 99%

Integrating experimental model, LC-MS/MS chemical analysis, and systems biology approach to investigate the possible antidiabetic effect and mechanisms of Matricaria aurea (Golden Chamomile) in type 2 diabetes mellitus

et al. 2022

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“…Therefore it is the need of time to have newer discoveries which could lead us towards better management of diabetes. [7] Linked to our desire to reach perfection in diabetes management and possibly ultimate eradication of this epidemically surging type-2 diabetes in world community with major burnt being shared by developing economies, the scene is set for innovation. Molecular medicine including gene therapy and genome editing provides innovative and creative ideologies with now some evidence in hand to allow us to visualize an improvement in diabetes biostatistics and associated morbidity and mortality.…”

Section: Introductionmentioning

confidence: 99%

Type-2 Diabetes and Gene Therapy: The Promise of CRISPR Gene Therapy in type-2 Diabetes Mellitus

Khan¹

2019

JOM

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Gene therapy has entered a new era with the dawn of CRISPR/Cas9 technology which though were always available in nature but rediscovered to tame into a real-tlife genome editing tool. With the modernization upsurge and changes in ways the “homo sapiens” survived on this planet from hunger to current era of exuberance has led to multiple metabolic issues like type-2 diabetes. Notwithstanding the rapid emergence of medication to suppress the hyperglycemia and insulin resistance associated with this menace, need has definitely emerge to find more personalized and curative dimensions to therapeutics of type-2 diabetes mellitus. Gene therapy is one more addition to Type-2 Diabetes Mellitus (T2DM) therapy, where multiple options have emerged in the shape of microRNA, direct knocking out of cellular structures like proteins and enzymes and very recently the precision nucleases associated with CRISPR technologies. This mini-review attempt to summarize some of the recent examples of gene therapy with major focus on CRISPR/Cas technologies.

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“…Several synthetic oral hypoglycemic agents are currently available for diabetes treatment, including metformin, sulphonylureas, thiazolidinedione, and rosiglitazone. However, adverse effects accompanied by the use of these drugs have arisen, such as weight gain, hypoglycemia, gastrointestinal intolerance, and fluid retention (Gomez‐Peralta and Abreu, ), whereas many herbal medicines have demonstrated their anti‐diabetic effects and potentialities for the treatment of diabetes with less adverse effects (Mukherjee et al , ). In addition, herbal medicines containing many chemical components are anticipated to act on various pathologic targets by various mechanisms simultaneously or reduce the incidence of drug resistance (Schmidt et al , ).…”

Section: Introductionmentioning

confidence: 99%

Effects of Lonicera japonica Thunb. on Type 2 Diabetes via PPAR-γ Activation in Rats

et al. 2015

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Lonicera japonica Thunb. (Caprifoliaceae) is a traditional herbal medicine and has been used to treat diabetic symptoms. Notwithstanding its use, the scientific basis on anti-diabetic properties of L. japonica is not yet established. This study is designed to investigate anti-diabetic effects of L. japonica in type 2 diabetic rats. L. japonica was orally administered at the dose of 100 mg/kg in high-fat diet-fed and low-dose streptozotocin-induced rats. After the treatment of 4 weeks, L. japonica reduced high blood glucose level and homeostatic model assessment of insulin resistance in diabetic rats. In addition, body weight and food intake were restored by the L. japonica treatment. In the histopathologic examination, the amelioration of damaged β-islet in pancreas was observed in L. japonica-treated diabetic rats. The administration of L. japonica elevated peroxisome proliferator-activated receptor gamma and insulin receptor subunit-1 protein expressions. The results demonstrated that L. japonica had anti-diabetic effects in type 2 diabetic rats via the peroxisome proliferator-activated receptor gamma regulatory action of L. japonica as a potential mechanism.

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Do we need new treatments for type 2 diabetes?

Cited by 7 publications

References 35 publications

Integrating experimental model, LC-MS/MS chemical analysis, and systems biology approach to investigate the possible antidiabetic effect and mechanisms of Matricaria aurea (Golden Chamomile) in type 2 diabetes mellitus

Integrating experimental model, LC-MS/MS chemical analysis, and systems biology approach to investigate the possible antidiabetic effect and mechanisms of Matricaria aurea (Golden Chamomile) in type 2 diabetes mellitus

Type-2 Diabetes and Gene Therapy: The Promise of CRISPR Gene Therapy in type-2 Diabetes Mellitus

Effects of Lonicera japonica Thunb. on Type 2 Diabetes via PPAR-γ Activation in Rats

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