Do we need to eradicate <i>Helicobacter pylori</i> in patients with GORD?

Masaoka, Tatsuhiro; Suzuki, Hidekazu

doi:10.1177/2050640613497713

Cited by 2 publications

(1 citation statement)

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“…La physiopathologie du RGO est multifactorielle [1]. Le RGO se caractérise par le reflux des sucs gastriques dans l'oesophage, ce qui provoque des symptômes typiques, commel ep yrosis avec ou sans lésions de la muqueuse oesophagienne [5]. Dans une grande proportion de patients, il n'y ap as de lésion endoscopique visible au niveau de l'oesophage en dépit de symptômest ypiques de RGO et de l'exposition acide de la muqueuse oesophagienne [6].…”

Section: Introductionunclassified

Prévalence de l’infection à Helicobacter pylori chez 103 patients avec reflux gastroœsophagien, œsophagite érosive ou un œsophage de Barrett à Yaoundé, Cameroun

Andoulo¹,

Kowo²,

Ngatcha³

et al. 2015

Hegel

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Introduction:The relationship between the Helicobacter pylori (H. pylori) infection and gastroesophageal reflux disease (GERD) is complex. Some epidemiological studies have suggested ap rotective role of the H. pylori infection in the development of GERD and its eradication would lead to the increase in GERD frequency. This article assesses the prevalence of the H. pylori infection among patients with GERD without injury, erosive esophagitis or Barrett's esophagus.Materials and methods: Between January and May 2015, 103 consecutive patients with daily or weekly GERD symptoms for at least one year were assessed at the Medical Center "la Cathédrale" of Yaoundé,C ameroon. All patients underwent anamnesis, physical examination, upper GI endoscopy with antral biopsies and rapid urease test HelicotecUT ® plus commercial kit (Strong Biotech Corp., Taipei, Taiwan). All statistical analyzes haveu sed the software Epi-Info 3.5.1 and the SPSS version 16.0 (IBM, Chicago, USA). Results:The study included 43 men and 60 women with an average ageo f4 6.5 ± 15.3y ears (range: 14-79 years). The prevalence of the H. pylori infection was 39.8% (95% CI: 30.4 to 49.3). H. pylori was positive in 34.6%o fp atients with erosive esophagitis against 41.6% in patients with endoscopy-negative GERD (p=0.533). Among the 41 H. pylori positive patients, only nine (22.0%) had erosive esophagitis, all of Savary-Miller grade 1. Conclusion:The prevalence of the H. pylori infection is low among the Cameroonian patients with GERD. Severe damage to the esophageal mucosa is rare among H. pylori positive patients comparedt oH. pylori negative ones. However, our data do not enable us have proof in defining the relationship between the H. pylori infection and GERD in our HP ylori endemic context. Further studies are awaited.

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Section: Introductionunclassified