Docking study for Protein Nsp-12 of SARS-CoV with Betalains and Alfa-Bisabolol

Lucas-Gómez, Isaac; López-Fernández, Abelardo; González-Pérez, Brenda Karen; Andrea, M. Rivas-Castillo; Calderón, A. Valdez; Gayosso-Morales, Manuel Aaron

doi:10.48550/arxiv.2012.14504

Cited by 1 publication

(1 citation statement)

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“…Overall, betacyanin exhibits the potential to act as an inhibitor against SARS-CoV-2 despite violating three of the four RO5 criteria. Lucas-Gómez et al (2020) reported comparable interactions between betalain and the SARS-CoV-2 nsp12 protein using in silico approaches, albeit the authors stated that any possible inhibitory effects would be of small magnitude. It must be noted that the specific betalain molecule studied was not stated in the research.…”

Section: Dengue Virusmentioning

confidence: 99%

Antimicrobial betalains

Wijesinghe

Choo

2022

Journal of Applied Microbiology

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Betalains are nitrogen-containing plant pigments that can be red-violet (betacyanins) or yellow-orange (betaxanthins), currently employed as natural colourants in the food and cosmetic sectors. Betalains exhibit antimicrobial activity against a broad spectrum of microbes including multidrug-resistant bacteria, as well as single-species and dual-species biofilm-producing bacteria, which is highly significant given the current antimicrobial resistance issue reported by The World Health Organization.Research demonstrating antiviral activity against dengue virus, in silico studies including SARS-CoV-2, and anti-fungal effects of betalains highlight the diversity of their antimicrobial properties. Though limited in vivo studies have been conducted, antimalarial and anti-infective activities of betacyanin have been observed in living infection models. Cellular mechanisms of antimicrobial activity of betalains are yet unknown; however existing research has laid the framework for a potentially novel antimicrobial agent. This review covers an overview of betalains as antimicrobial agents and discussions to fully exploit their potential as therapeutic agents to treat infectious diseases.

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Section: Dengue Virusmentioning

confidence: 99%