Documento de consenso hispano-portugués para el uso de la terapia fotodinámica con metil aminolevulinato y luz de día en el tratamiento de las queratosis actínicas

Gilaberte, Yolanda; Aguilar, M.; Almagro, Manuel; Correia, Osvaldo; Guillén, C.; Harto, A.; Pérez‐García, B.; Pérez-Pérez, L.; Redondo, Pedro; Sánchez‐Carpintero, I.; Serra‐Guillén, C.; Valladares, Luis Miguel

doi:10.1016/j.ad.2015.06.001

Cited by 23 publications

(10 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…PDT using artificial white light has been shown to be as effective and well-tolerated as daylight photodynamic therapy (DL-PDT) for actinic keratosis (O'Gorman et al, 2016). DL-PDT is a new PDT modality in which the photosensitizer is activated by sunlight rather than a lamp (Enk et al, 2015; Gilaberte et al, 2015; Morton et al, 2015). The use of daylight makes the PDT procedure simpler and more efficient (de Berker et al, 2007; Wiegell et al, 2012; Vignion-Dewalle et al, 2015).…”

Section: Discussionmentioning

confidence: 99%

Bactericidal Effect of Photodynamic Therapy, Alone or in Combination with Mupirocin or Linezolid, on Staphylococcus aureus

et al. 2017

View full text Add to dashboard Cite

Antibiotic treatments frequently fail due to the development of antibiotic resistance, underscoring the need for new treatment strategies. Antimicrobial photodynamic therapy (aPDT) could constitute an alternative therapy. In bacterial suspensions of Staphylococcus aureus, which is commonly implicated in cutaneous and mucosal infections, we evaluated the in vitro efficacy of aPDT, using the photosensitizing agents rose bengal (RB) or methylene blue (MB), alone or combined with the antibiotics mupirocin (MU) or linezolid (LN). RB or MB, at concentrations ranging from 0.03 to 10 μg/ml, were added to S. aureus ATCC 29213 suspensions containing >108 cells/ml, in the absence or presence of MU or LN (1 or 10 μg/ml). Suspensions were irradiated with a white metal halide (λ 420–700 nm) or light-emitting diode lamp (λ 515 and λ 625 nm), and the number of viable bacteria quantified by counting colony-forming units (CFU) on blood agar. Addition of either antibiotic had no significant effect on the number of CFU/ml. By contrast, RB-aPDT and MB-aPDT effectively inactivated S. aureus, as evidenced by a 6 log10 reduction in bacterial growth. In the presence of MU or LN, the same 6 log10 reduction was observed in response to aPDT, but was achieved using significantly lower concentrations of the photosensitizers RB or MB. In conclusion, the combination of MU or LN and RB/MB-aPDT appears to exert a synergistic bactericidal effect against S. aureus in vitro.

show abstract

Section: Discussionmentioning

confidence: 99%

Bactericidal Effect of Photodynamic Therapy, Alone or in Combination with Mupirocin or Linezolid, on Staphylococcus aureus

et al. 2017

View full text Add to dashboard Cite

show abstract

“…Since the US Food and Drug Administration listed PDT as a new treatment method for the clinical treatment of cancer patients[ 3 ], alone or combined with surgery[ 4 ] and/or chemotherapy[ 5 ], PDT has been applied in large numbers worldwide. For PDT treatment, some Western countries have established relatively systematic treatment plans[ 6 - 8 ]. The main mechanism of PDT depends on the reactive oxygen species (ROS) components generated by the photochemical reaction, which can oxidize a large number of intracellular active components (such as DNA and lipid compounds) in tumor cells[ 9 , 10 ].…”

Section: Introductionmentioning

confidence: 99%

Photodynamic therapy regulates fate of cancer stem cells through reactive oxygen species

Zhang

Wang

et al. 2020

WJSC

View full text Add to dashboard Cite

Photodynamic therapy (PDT) is an effective and promising cancer treatment. PDT directly generates reactive oxygen species (ROS) through photochemical reactions. This oxygen-dependent exogenous ROS has anti-cancer stem cell (CSC) effect. In addition, PDT may also increase ROS production by altering metabolism, endoplasmic reticulum stress, or potential of mitochondrial membrane. It is known that the half-life of ROS in PDT is short, with high reactivity and limited diffusion distance. Therefore, the main targeting position of PDT is often the subcellular localization of photosensitizers, which is helpful for us to explain how PDT affects CSC characteristics, including differentiation, self-renewal, apoptosis, autophagy, and immunogenicity. Broadly speaking, excess ROS will damage the redox system and cause oxidative damage to molecules such as DNA, change mitochondrial permeability, activate unfolded protein response, autophagy, and CSC resting state. Therefore, understanding the molecular mechanism by which ROS affect CSCs is beneficial to improve the efficiency of PDT and prevent tumor recurrence and metastasis. In this article, we review the effects of two types of photochemical reactions on PDT, the metabolic processes, and the biological effects of ROS in different subcellular locations on CSCs.

show abstract

“…To date, a specific treatment algorithm for first- and second-line therapies is missing, due to the lack of comparative studies. The existing guidelines often lack specific recommendations upon important patient characteristics such as a lesion’s properties and number, the anatomical site involved, the patient’s comorbidities, the devices availability and the dermatologist’s experience [ 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 ]. As it is impossible to predict which AK will transform into invasive SCC, all lesions need to be treated.…”

Section: Introductionmentioning

confidence: 99%

“…However, it is important to consider some criteria before deciding which treatment will be indicated for each patient. Several treatments are available including lesion and field-directed options [ 6 , 8 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 ]. Among field treatment options, photodynamic therapy has been recognized as a key treatment [ 6 , 8 , 9 , 11 ].…”

Section: Introductionmentioning

confidence: 99%

“…Conventional treatment using occlusive methyl aminolevulinate (MAL) cream, Metvix ® ; (Galderma Laboratories, Paris, France) for 3 h is an effective procedure for AK and NMSCs. Although conventional (c)-MAL-PDT is a successful treatment for AK, poorer tolerability, long clinic visits, extended treatment times and costly instrumentation limit its wider use [ 7 , 12 ]. To overcome these limitations, Daylight PDT with MAL (DL-PDT) has been developed, showing the same efficacy as c-PDT, with almost no pain and a lower rate of local adverse events [ 6 , 7 , 9 , 10 ].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

MAL Daylight Photodynamic Therapy for Actinic Keratosis: Clinical and Imaging Evaluation by 3D Camera

Cantisani

Paolino

Pellacani

et al. 2016

IJMS

View full text Add to dashboard Cite

Non-melanoma skin cancer is the most common skin cancer with an incidence that varies widely worldwide. Among them, actinic keratosis (AK), considered by some authors as in situ squamous cell carcinoma (SCC), are the most common and reflect an abnormal multistep skin cell development due to the chronic ultraviolet (UV) light exposure. No ideal treatment exists, but the potential risk of their development in a more invasive form requires prompt treatment. As patients usually present with multiple AK on fields of actinic damage, there is a need for effective, safe, simple and short treatments which allow the treatment of large areas. To achieve this, daylight photodynamic therapy (DL-PDT) is an innovative treatment for multiple mild actinic keratosis, well tolerated by patients. Patients allocated to the PDT unit, affected by multiple mild−moderate and severe actinic keratosis on sun-exposed areas treated with DL-PDT, were clinically evaluated at baseline and every three months with an Antera 3D, Miravex© camera. Clinical and 3D images were performed at each clinical check almost every three months. In this retrospective study, 331 patients (56.7% male, 43.3% female) were treated with DL-PDT. We observed a full clearance in more than two-thirds of patients with one or two treatments. Different responses depend on the number of lesions and on their severity; for patients with 1–3 lesions and with grade I or II AK, a full clearance was reached in 85% of cases with a maximum of two treatments. DL-PDT in general improved skin tone and erased sun damage. Evaluating each Antera 3D images, hemoglobin concentration and pigmentation, a skin color and tone improvement in 310 patients was observed. DL-PDT appears as a promising, effective, simple, tolerable and practical treatment for actinic damage associated with AK, and even treatment of large areas can be with little or no pain. The 3D imaging allowed for quantifying in real time the aesthetic benefits of DL-PDT’s increasing compliance.

show abstract

Documento de consenso hispano-portugués para el uso de la terapia fotodinámica con metil aminolevulinato y luz de día en el tratamiento de las queratosis actínicas

Cited by 23 publications

References 22 publications

Bactericidal Effect of Photodynamic Therapy, Alone or in Combination with Mupirocin or Linezolid, on Staphylococcus aureus

Bactericidal Effect of Photodynamic Therapy, Alone or in Combination with Mupirocin or Linezolid, on Staphylococcus aureus

Photodynamic therapy regulates fate of cancer stem cells through reactive oxygen species

MAL Daylight Photodynamic Therapy for Actinic Keratosis: Clinical and Imaging Evaluation by 3D Camera

Contact Info

Product

Resources

About