DODAB-DOPE liposome surface coating using in-situ acrylic acid polymerization

Ramirez, Romelly Eugenia Rojas; Orth, Elisa S.; Pires, Cassiano; Zawadzki, Sônia Faria; Freitas, Rilton Alves de

doi:10.1016/j.molliq.2021.115689

Cited by 4 publications

(2 citation statements)

References 35 publications

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“…are spherical enclosed vesicles formed by phospholipid bilayer [46,47]. Liposome was first discovered by A. D. Bangham in 1965 and used for small molecule drug delivery for a long time, with particle size range from 20 nm to 1000 nm [48,49]. In addition to the encapsulation of small molecule chemotherapeutic drugs, more and more studies focus on the encapsulation and delivery ability of liposomes for gene drugs (including mRNA, pDNA, siRNA et al), protein drugs, hormone drugs and so on.…”

Section: Liposomementioning

confidence: 99%

The nano delivery systems and applications of mRNA

et al. 2022

European Journal of Medicinal Chemistry

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Section: Liposomementioning

confidence: 99%

The nano delivery systems and applications of mRNA

et al. 2022

European Journal of Medicinal Chemistry

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“…Coated liposomes have demonstrated that drug activity was synergically increased, along with many other desirable biological effects [11]. The surface modification of liposomes can be obtained by following different processes, such as polymer adsorption [12]. Furthermore, surface coating with a polymer is able to preserve liposome stability [13], and this behavior depends on the ability of the polymer to adhere to the lipid bilayers [14].…”

Section: Introductionmentioning

confidence: 99%

Physicochemical Characterization of Hyaluronic Acid and Chitosan Liposome Coatings

et al. 2021

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Hyaluronic acid (HA) and chitosan (CH) are biopolymers that are widely used in many biomedical applications and for cosmetic purposes. Their chemical properties are fundamental to them working as drug delivery systems and improving their synergistic effects. In this work, two different protocols were used to obtain zwitterionic liposomes coated with either hyaluronic acid or chitosan. Specifically, the methodologies used to perform vesicle preparation were chosen by taking into account the specific chemical properties of these two polysaccharides. In the case of chitosan, liposomes were first synthesized and then coated, whereas the coating of hyaluronic acid was achieved through lipidic film hydration in an HA aqueous solution. The size and the zeta-potential of the polysaccharide-coated liposomes were determined by dynamic light scattering (DLS). This approach allowed coated liposomes to be obtained with hydrodynamic diameters of 264.4 ± 12.5 and 450.3 ± 16.7 nm for HA- and CH-coated liposomes, respectively. The chemical characterization of the coated liposomal systems was obtained by surface infrared (ATR-FTIR) and nuclear magnetic resonance (NMR) spectroscopies. In particular, the presence of polysaccharides was confirmed by the bands assigned to amides and saccharides being in the 1500–1700 cm−1 and 800–1100 cm−1 regions, respectively. This approach allowed confirmation of the efficiency of the coating processes, evidencing the presence of HA or CH at the liposomal surface. These data were also supported by time-of-flight secondary ion mass spectrometry (ToF-SIMS), which provided specific assessments of surface (3–5 nm deep) composition and structure of the polysaccharide-coated liposomes. In this work, the synthesis and the physical chemistry characterization of coated liposomes with HA or CH represent an important step in improving the pharmacological properties of drug delivery systems.

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