Doença de Chagas e a seguridade social: caracterização da doença no sistema previdenciário e assistencial brasileiro, 2004-2016

Perissato, Izabela Lima; Santos, Keile Aparecida Resende; Oliveira, Antônio Marcos Machado de; Limongi, Jean Ezequiel

doi:10.1590/s2237-96222022000200006

Cited by 5 publications

(16 citation statements)

References 14 publications

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“…This partly explains the fact that most of the individuals in the study were men. In addition, overall, CD has a more severe and disabling evolution in men, who traditionally seek healthcare services less for diagnosis and appropriate treatment 3 .…”

Section: Discussionmentioning

confidence: 99%

“…In absolute numbers, the Southeast macroregion was the one with the highest frequency of beneficiaries. In addition to being the most populous and urbanized macroregion in the country, it has higher human development indexes, making its resident population more apt to contribute to social security and more informed about existing and pertinent welfare rights 3 . The macroregion also encompasses two historically very important states for CD transmission: Minas Gerais and São Paulo 1 , 3 .…”

Section: Discussionmentioning

confidence: 99%

“…The largest number of benefits were granted to individuals affected by the cardiac form of CD. Chronic CD with heart involvement is the most frequent clinical form with great disabling potential, especially for workers who exert great physical efforts in their work activities 3 , 22 .…”

Section: Discussionmentioning

confidence: 99%

“…Survival among patients with CD with the digestive clinical form was considerably higher when compared with those affected by the cardiac form. Indeed, chronic CD with heart involvement is associated with higher mortality 3 , 6 , 8 , 9 , 25 . However, in a study on CD mortality between 2000 and 2010, an increase in mortality related to the digestive system was observed 25 .…”

Section: Discussionmentioning

confidence: 99%

“…CD, especially chronic CD with heart involvement, has great disabling potential, removing individuals with productive potential from the labor market 3 . In addition to physical disability, CD patients suffer from psychological impacts, such as fear, stress, anxiety, low self-esteem, depression, and, consequently, they have a low quality of life 1 , 4 , 5 .…”

Section: Introductionmentioning

confidence: 99%

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Survival analysis of Chagas disease patients, beneficiaries of social security and social assistance in Brazil, 1942–2016

Limongi,

Santos,

Perissato

et al. 2024

Rev. bras. epidemiol.

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Objective To analyze the survival of patients with Chagas disease, beneficiaries of social security and social assistance, in Brazil, from 1942 to 2016. Methods This is a retrospective cohort study with data from the Brazilian Ministry of Social Security. The event of interest was death, and the survival functions were estimated by the Kaplan-Meier and Cox regression methods. Results In the period “onset of the disease until death”, women (HR=0.54; 95%CI 0.43–0.53) and receiving social security benefits (HR=0.13; 95%CI 0.11–0.23) were associated with longer survival. Lower survival was associated with the cardiac form of the disease (HR=2.64; 95%CI 2.23–3.12), living in a rural area (HR=1.23; 95%CI 1.14–1.21), and manifestation of the disease between the years 2000 and 2016 (HR=5.32; 95%CI 4.74–5.93). Likewise, in the period “work disability until death”, women (HR=0.51; 95%CI 0.41–0.52) and receiving social security benefits (HR=0.24; 95%CI 0,14–0.45) were associated with longer survival, as well as the cardiac form of the disease (HR=1.95; 95%CI 1.83–2.13), living in a rural area (HR=1.31; 95%CI 1.21–1.54), and manifestation of the disease between 2000 and 2016 (HR=1.53; 95%CI 1.33–1.71) were associated with lower survival. Conclusion The main predictors of mortality and survival of patients with Chagas disease who receive social security and assistance benefits in Brazil were presented. These findings can guide the definition of priorities for follow-up actions by Primary Health Care, currently recommended for the longitudinal management of the disease.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Survival analysis of Chagas disease patients, beneficiaries of social security and social assistance in Brazil, 1942–2016

Limongi,

Santos,

Perissato

et al. 2024

Rev. bras. epidemiol.

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Análise de sobrevida de portadores da doença de Chagas, beneficiários da previdência e da assistência social no Brasil, 1942–2016

Limongi,

Santos,

Perissato

et al. 2024

Rev. bras. epidemiol.

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RESUMO Objetivo Analisar a sobrevida de portadores da doença de Chagas, beneficiários da previdência e da assistência social no Brasil, 1942-2016. Métodos Estudo de coorte retrospectivo com dados do Ministério da Previdência Social. O evento de interesse foi o óbito, e as funções de sobrevida foram estimadas pelos métodos Kaplan-Meier e de regressão de Cox. Resultados No período “início da doença até o óbito”, o sexo feminino (HR=0,54; IC95% 0,43–0,53) e recebimento de benefícios previdenciários (HR=0,13; IC95% 0,11–0,23) foram associados a maior sobrevida. A menor sobrevida esteve associada à forma cardíaca da doença (HR=2,64; IC95% 2,23–3,12), residência em zona rural (HR=1,23; IC95% 1,14–1,21) e manifestação da doença entre os anos de 2000 e 2016 (HR=5,32; IC95% 4,74–5,93). Da mesma forma, no período “incapacidade laboral até o óbito”, o sexo feminino (HR=0,51; IC95% 0,41–0,52) e o recebimento de benefícios previdenciários (HR=0,24; IC95% 0,14–0,45) foram associados a maior sobrevida, assim como forma cardíaca da doença (HR=1,95; IC95% 1,83–2,13), residência em zona rural (HR=1,31; IC95% 1,21–1,54) e manifestação da doença entre os anos de 2000 e 2016 (HR=1,53; IC95% 1,33–1,71) associaram-se a menor sobrevida. Conclusão Os principais preditores de mortalidade e sobrevida de portadores de doença de Chagas que recebem benefícios previdenciários e assistenciais no Brasil foram apresentados. Estes achados podem nortear a definição de prioridades de ações de acompanhamento pela atenção primária à saúde, preconizada atualmente para o manejo longitudinal da doença.

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Recombinant proteins as promising antigens applied to the immunodiagnosis of Chagas disease: a scoping review

Resende,

Ribeiro,

Gandra

et al. 2024

Front. Microbiol.

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Chagas disease (CD), caused by the protozoan Trypanosoma cruzi, is an important public health problem, occurring mainly in Latin America. The disease has a major social and economical effect, negatively impacting the life of the infected individuals, and bringing great costs to public health. An early and accurate diagnosis is essential for administration of early treatment. In addition, prognostic tests may aid disease management, decreasing hospitalization costs. However, the serological diagnostic scenario for CD still faces several challenges, making the development of new diagnostic kits a pressing matter. Facing this scenario, several researchers have expanded efforts in developing and testing new antigens, such as recombinant proteins and recombinant multiepitope proteins, with promising results. These recombinant antigens offer several advantages, such as improved sensitivity and specificity, in addition to facilitated scaling. Also, it has been possible to observe a rising number of studies using ELISA and point-of-care platforms, employing these antigens in the past few years. Among them, recombinant proteins were the most applied antigens, demonstrating great capacity to discriminate between positive and negative samples. Although fewer in number, recombinant multiepitope proteins also demonstrated an improved diagnostic performance. Indeed, a great number of studies employing these antigens showed sensitivity and specificity values above 90%, greatly impacting diagnostic accuracy. Nevertheless, despite the good results found, it is still possible to observe some bottlenecks in the development of new antigens, such as the scarcity of tests with sera from the acute phase and the variability of results in different geographic areas. In this sense, aiming to contribute to control and health programs, the continuous search for a more accurate serological diagnosis is essential, both for the acute and chronic phases of the disease.

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Doença de Chagas e a seguridade social: caracterização da doença no sistema previdenciário e assistencial brasileiro, 2004-2016

Cited by 5 publications

References 14 publications

Survival analysis of Chagas disease patients, beneficiaries of social security and social assistance in Brazil, 1942–2016

Survival analysis of Chagas disease patients, beneficiaries of social security and social assistance in Brazil, 1942–2016

Análise de sobrevida de portadores da doença de Chagas, beneficiários da previdência e da assistência social no Brasil, 1942–2016

Recombinant proteins as promising antigens applied to the immunodiagnosis of Chagas disease: a scoping review

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