Does a Dysbiotic Oral Microbiome Trigger the Risk of Chronic Inflammatory Disease?

Jiménez De Nunzio, Sofía; Portal-Núñez, Sergio; Arias Macías, Caridad M.; Bruna Del Cojo, Marta; Adell-Pérez, Carlos; Latorre Molina, María; Macías-González, Manuel; Adell-Pérez, Ana

doi:10.1007/s40521-023-00355-4

Curr Treat Options Allergy

2023

DOI: 10.1007/s40521-023-00355-4

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Does a Dysbiotic Oral Microbiome Trigger the Risk of Chronic Inflammatory Disease?

Sofía Jiménez De Nunzio,

Sergio Portal-Núñez,

Caridad M. Arias Macías

et al.

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2024

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Cited by 2 publications

References 131 publications

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Oral Microbiome Research in Biopsy Samples of Oral Potentially Malignant Disorders and Oral Squamous Cell Carcinoma and Its Challenges

Špiljak,

Ozretić,

Andabak Rogulj

et al. 2024

Applied Sciences

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This study aims to evaluate the potential benefits and challenges of integrating oral microbiome research into the clinical management of oral potentially malignant disorders (OPMD) and oral squamous cell carcinoma (OSCC). The oral microbiome has gained significant attention for its role in the pathogenesis and progression of these conditions, with emerging evidence suggesting its value as a diagnostic and prognostic tool. By critically analyzing current evidence and methodological considerations, this manuscript examines whether microbiome analysis in biopsy samples can aid in the early detection, prognosis, and management of OPMD and OSCC. The complexity and dynamic nature of the oral microbiome require a multifaceted approach to fully understand its clinical utility. Based on this review, we conclude that studying the oral microbiome in this context holds significant promise but also faces notable challenges, including methodological variability and the need for standardization. Ultimately, this manuscript addresses the question, “Should such research be undertaken, given the intricate interactions of various factors and the inherent obstacles involved?”, and also emphasizes the importance of further research to optimize clinical applications and improve patient outcomes.

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Oral Microbiome Research in Biopsy Samples of Oral Potentially Malignant Disorders and Oral Squamous Cell Carcinoma and Its Challenges

Špiljak,

Ozretić,

Andabak Rogulj

et al. 2024

Applied Sciences

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Mechanistic Insights on Microbiota-Mediated Development and Progression of Esophageal Cancer

Moe,

Tan

2024

Cancers

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Esophageal cancer (EC) is one of the most common malignant tumors worldwide, and its two major types, esophageal adenocarcinoma (EAC) and esophageal squamous cell carcinoma (ESCC), present a severe global public health problem with an increasing incidence and mortality. Established risk factors include smoking, alcohol consumption, and dietary habits, but recent research has highlighted the substantial role of oral microbiota in EC pathogenesis. This review explores the intricate relationship between the microbiome and esophageal carcinogenesis, focusing on the following eight significant mechanisms: chronic inflammation, microbial dysbiosis, production of carcinogenic metabolites, direct interaction with epithelial cells, epigenetic modifications, interaction with gastroesophageal reflux disease (GERD), metabolic changes, and angiogenesis. Certain harmful bacteria, such as Porphyromonas gingivalis and Fusobacterium nucleatum, are specifically implicated in sustaining irritation and tumor progression through pathways including NF-κB and NLRP3 inflammasome. Additionally, the review explores how microbial byproducts, including short-chain fatty acids (SCFAs) and reactive oxygen species (ROS), contribute to DNA harm and disease advancement. Furthermore, the impact of reflux on microbiota composition and its role in esophageal carcinogenesis is evaluated. By combining epidemiological data with mechanistic understanding, this review underscores the potential to target the microbiota–immune system interplay for novel therapeutic and diagnostic strategies to prevent and treat esophageal cancer.

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Does a Dysbiotic Oral Microbiome Trigger the Risk of Chronic Inflammatory Disease?

Cited by 2 publications

References 131 publications

Oral Microbiome Research in Biopsy Samples of Oral Potentially Malignant Disorders and Oral Squamous Cell Carcinoma and Its Challenges

Oral Microbiome Research in Biopsy Samples of Oral Potentially Malignant Disorders and Oral Squamous Cell Carcinoma and Its Challenges

Mechanistic Insights on Microbiota-Mediated Development and Progression of Esophageal Cancer

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