Does a glass of red wine improve endothelial function?

Agewall, Stefan; Wright, Stephen P.; Doughty, Robert N.; Whalley, Gillian A.; Duxbury, Mark; Sharpe, Norman

doi:10.1053/euhj.1999.1759

Cited by 190 publications

(124 citation statements)

References 29 publications

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“…The significant increase in acute FMD following consumption of the polyphenol-rich drink is consistent with other studies conducted in non-athlete populations [16][17][18][19]. For instance, FMD was increased after consumption of 477 mg of polyphenols from non-alcoholized red wine in healthy subjects [18].…”

Section: Study 1-polyphenols and Fmdsupporting

confidence: 79%

Acute Effects of Polyphenols from Cranberries and Grape Seeds on Endothelial Function and Performance in Elite Athletes

Labonté

Couillard

Motard-Belanger

et al. 2013

Sports

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Abstract:We examined how intake of polyphenols modifies brachial artery flow-mediated dilation (FMD) at rest, and cycling anaerobic performance, in elite athletes. In the first randomized cross-over study, FMD was measured over a three-hour period on two occasions in eight elite male and female athletes after acute consumption of either polyphenols from cranberries and grape seeds (600 mg) or a polyphenol-free placebo drink. Consumption of the polyphenol-rich drink led to a significant increase in FMD compared to placebo (p = 0.02), with a peak at 60 min. In a second study, 12 elite male and female athletes completed a threekilometer time trial (TT) on an ergocycle on two occasions in random order, either after consumption of 800 mg of polyphenols or a placebo. Acute intake of the polyphenol extract had no impact on the three-kilometer time trial completion. However, plasma lactate levels were significantly lower before and after the TT when subjects consumed the polyphenols vs. placebo (p < 0.05). Results suggest that polyphenols from cranberries and grape seeds acutely modifies FMD at rest in elite athletes but this does not translate into enhanced cycling anaerobic performance. OPEN ACCESSSports 2013, 1 56

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Section: Study 1-polyphenols and Fmdsupporting

confidence: 79%

Acute Effects of Polyphenols from Cranberries and Grape Seeds on Endothelial Function and Performance in Elite Athletes

Labonté

Couillard

Motard-Belanger

et al. 2013

Sports

View full text Add to dashboard Cite

show abstract

“…Other investigators have observed favorable vascular effects of black and green tea [58,59]. As outlined in the Table 1, improved endothelial function has also been demonstrated following consumption of other flavonoid-containing beverages and foods, including grape juice [49,60] wine, [61], dealcoholized red wine [62], cocoa [63][64][65], and chocolate [66].…”

Section: Flavonoids and Endothelial Functionmentioning

confidence: 83%

Effects of Flavonoid-Containing Beverages and EGCG on Endothelial Function

Shenouda

Vita

2007

Journal of the American College of Nutrition

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Abnormalities of the vascular endothelium contribute to all stages of atherosclerosis from lesion development to clinical cardiovascular disease events. Recognized risk factors, including diabetes mellitus, hypertension, dyslipidemia, cigarette smoking, and sedentary lifestyle are associated with endothelial dysfunction. A variety of pharmacological and behavioral interventions have been shown to reverse endothelial dysfunction in patients with cardiovascular disease. A large number of epidemiological studies suggest that dietary factors, including increased intake of flavonoidcontaining foods and beverages, reduce cardiovascular risk, and recent studies have shown that such beverages have favorable effects on endothelial function. These studies have engendered interest in the development of dietary supplements or drugs that would allow for more convenient and higher dose administration of flavonoids and might prove useful for prevention or treatment of cardiovascular disease. In this paper, we will review the contribution of endothelial dysfunction to the pathogenesis and clinical expression of atherosclerosis and recent data linking flavonoid and EGCG consumption to improved endothelial function and reduced cardiovascular risk.

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“…Stein et al (41) observed that consumption of purple grape juice for 2 or 4 wk improved endothelium-dependent brachial artery flow-mediated dilation in patients with coronary artery disease. Dealcoholized wine also improved brachial artery flow-mediated dilation in healthy subjects (55). Interestingly, red wine consumption prevents the acute impairment of endothelial function that occurs following cigarette smoking (56) or consumption of a high-fat meal (57).…”

Section: Epidemiologymentioning

confidence: 98%

Grapes and Cardiovascular Disease

Dohadwala

Vita

2009

The Journal of Nutrition

182

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Epidemiological studies suggest that consumption of wine, grape products, and other foods containing polyphenols is associated with decreased risk for cardiovascular disease. The benefits of wine consumption appear to be greater than other alcoholic beverages. Experimental studies indicate that grape polyphenols could reduce atherosclerosis by a number of mechanisms, including inhibition of oxidation of LDL and other favorable effects on cellular redox state, improvement of endothelial function, lowering blood pressure, inhibition of platelet aggregation, reducing inflammation, and activating novel proteins that prevent cell senescence, e.g. Sirtuin 1. Translational studies in humans support these beneficial effects. More clinical studies are needed to confirm these effects and formulate dietary guidelines. The available data, however, strongly support the recommendation that a diet rich in fruits and vegetables, including grapes, can decrease the risk for cardiovascular disease.

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Does a glass of red wine improve endothelial function?

Cited by 190 publications

References 29 publications

Acute Effects of Polyphenols from Cranberries and Grape Seeds on Endothelial Function and Performance in Elite Athletes

Acute Effects of Polyphenols from Cranberries and Grape Seeds on Endothelial Function and Performance in Elite Athletes

Effects of Flavonoid-Containing Beverages and EGCG on Endothelial Function

Grapes and Cardiovascular Disease

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