Does adenotonsillectomy alter IGF-1 and ghrelin serum levels in children with adenotonsillar hypertrophy and failure to thrive? A prospective study

Moghaddam, Yalda Jabbari; Golzari, Samad Ej; Saboktakin, Lida; Seyedashrafi, Mir Hojjat; Sabermarouf, Babak; Gavgani, Heidar Ali Esmaeili; Haghjo, Amir Ghorbani; Lotfi, Alireza; Ghabili, Kamyar

doi:10.1016/j.ijporl.2013.06.029

Cited by 11 publications

(7 citation statements)

References 15 publications

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“…Ghrelin: Ghrelin levels increased significantly post-op vs. pre-op ( p < 0.001), as reported in one study [ 30 ] and decreased 1-year post-op, as shown in another study ( p < 0.001) [ 29 ].…”

Section: Resultssupporting

confidence: 65%

“…The PRISMA flow diagram ( Figure 1 ) summarizes the study screening process. A summary of the studies included in this systematic review and the grading of evidence is reported in Table 1 [ 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 ].…”

Section: Resultsmentioning

confidence: 99%

“…Only three studies, classified as low level of evidence, reported data on hormonal changes, and below, we report a summary of the results [ 20 , 29 , 30 ] ( Table 3 ).…”

Section: Resultsmentioning

confidence: 99%

“…IGF-1: The three studies measured IGF-1 levels pre-op and post-operation. IGF-1 levels increased significantly post-op vs. pre-op ( p < 0.001) in two studies [ 29 , 30 ], whereas in the other study, only the obstructive group showed an increase in IGF-1 ( p < 0.0001), but not the infection group ( p = 0.0883) [ 20 ].…”

Section: Resultsmentioning

confidence: 99%

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Short-Term Weight Gain after Tonsillectomy Does Not Lead to Overweight: A Systematic Review

Buono,

Maines,

Azzolini

et al. 2024

Nutrients

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Different studies and systematic reviews have reported weight increase after tonsillectomy. However, the odds of a child being overweight or obese after tonsillectomy were no different than before surgery, according to a few studies. This systematic review aims to analyze the impact of adenotonsillectomy (TA) on weight gain and identify subgroups of children and adolescents at risk of experiencing weight gain. A systematic search included studies published in the last ten years. The PICO framework was used in the selection process, and evidence was assessed using the GRADE system. A total of 26 studies were included, and moderate–high level quality ones showed that children who underwent TA could present an increase in BMI z-score. However, this weight gain was significant in individuals younger than six years old and was considered catch-up growth in underweight subjects at baseline. In contrast, for normal-weight or overweight individuals, TA did not lead to overweight per se. At the same time, diet changes and overfeeding did not have a leading role in weight gain. In conclusion, TA may not be an independent risk factor for unfavorable weight gain in children; however, individuals who were underweight pre-operatively or younger than six years reported more weight gain after TA than expected.

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Section: Resultssupporting

confidence: 65%

Section: Resultsmentioning

confidence: 99%

“…Only three studies, classified as low level of evidence, reported data on hormonal changes, and below, we report a summary of the results [ 20 , 29 , 30 ] ( Table 3 ).…”

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

See 2 more Smart Citations

Short-Term Weight Gain after Tonsillectomy Does Not Lead to Overweight: A Systematic Review

Buono,

Maines,

Azzolini

et al. 2024

Nutrients

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“…In medical studies, an increase in anthropometric IGF-1 and IGFBP-3 was found in children with obstructive sleep apnea syndrome OSAS or ATH after surgical treatment [ 11 , 28 , 29 ]. These children experienced eating difficulty, dysphagia, and high energy consumption due to obstruction of the upper respiratory tract and sleep disorders.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of the relationship between pain inflammation due to dental caries and growth parameters in preschool children

et al. 2023

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Objectives To evaluate the relationship between pain inflammation due to dental caries and growth parameters, sleep disturbances, and oral health-related quality of life (OHRQoL) in preschool children before/after dental treatment and compare the results with the control group. Materials and methods Study (pain inflammation due to caries) and control groups were included in this prospective clinical trial. The Child Sleep Habits Questionnaire (CSHQ) assessing sleep disturbances and the Early Childhood Oral Health Impact Scale (ECOHIS) assessing OHRQoL were applied in the corresponding time intervals to the study and control groups, respectively: baseline (T0 study ), 7 days after treatment (T1 study ), and following 6 months (T2 study ); baseline (T0 control ), and the following 6 months (T2 control ). Biochemical growth parameters (insulin-like growth factor-1 and insulin-like growth factor binding protein-3) and anthropometric measurements (standard deviation score of height, weight, and body mass index) were obtained at T0 study , T2 study , and T0 control . Mann-Whitney U and the Student t -tests were used for statistical analyses. The significance level was set at p < 0.05. Results Data on 45 children (mean age: 55.6 ± 10.37 months) were analyzed. T2 study was statistically higher than T0 study for the anthropometric measurements and biochemical growth parameters ( p < 0.05). T0 study was statistically higher than T0 control for biochemical growth parameters ( p < 0.05). CSHQ and ECOHIS scores were found statistically significant at T0 study than T0 control ( p < 0.05). Statistical scores of CSHQ and ECOHIS in T2 study were significantly reduced compared to T0 study ( p < 0.05). Conclusion Children’s growth parameters, sleep disturbances, and OHRQoL improved after the elimination of pain and inflammation. Clinical relevance This study’s novelty is the observation of drastically increased growth parameters and reduced sleep disturbances following dental treatment.

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Impact of tonsillectomy on dysphagia symptoms and body weight in children

Inja

Paul

Varghese

et al. 2020

American Journal of Otolaryngology

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Does adenotonsillectomy alter IGF-1 and ghrelin serum levels in children with adenotonsillar hypertrophy and failure to thrive? A prospective study

Cited by 11 publications

References 15 publications

Short-Term Weight Gain after Tonsillectomy Does Not Lead to Overweight: A Systematic Review

Short-Term Weight Gain after Tonsillectomy Does Not Lead to Overweight: A Systematic Review

Evaluation of the relationship between pain inflammation due to dental caries and growth parameters in preschool children

Impact of tonsillectomy on dysphagia symptoms and body weight in children

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