Does ADMA effect the oxidant/antioxidant balance in rats?

Alaçam, Hasan; Avcı, Bahattin; Şalış, Osman; Dilek, Ahmet; Kozan, Ahmet; Mertoğlu, Cuma; Şahin, Mehmet; Okuyucu, Ali

doi:10.3906/sag-1206-11

Cited by 8 publications

(11 citation statements)

References 67 publications

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“…ADMA administered to the rats in our study may have caused a reduction in DDAH activity and consequently there may have been excessive amounts of ADMA in the liver. This possibility is not unlikely when the oxidative stress-increasing effect of ADMA is considered (Alaçam et al, 2013). However, antioxidant ascorbic acid administered to the rats did not provide sufficient recovery of either biochemical or histopathological parameters.…”

Section: Discussionmentioning

confidence: 93%

“…We chose the time and dosage for this study based on the literature. (Alaçam et al, 2013;Okuyucu et al, 2015). Different doses and durations may be tested in future studies.…”

Section: Discussionmentioning

confidence: 99%

“…(Donpunha et al, 2011;Nagda and Bhatt, 2011;Alaçam et al, 2013). ADMA was dissolved in sterile 0.9% NaCl and each rat was given 0.2 mL.…”

Section: Study Groupsmentioning

confidence: 99%

“…ADMA alters the body's response against inflammation by causing changes in the inflammatory mediators (Avci et al, 2015). On the other hand, ADMA causes increased levels of malondialdehyde (MDA) as one of the oxidative stress indicators, whereas it results in reduced activities of antioxidant enzymes such as catalase, superoxide dismutase (SOD), and glutathione peroxidase (GSH-Px) (Alaçam et al, 2013). All these effects of ADMA on NO synthesis, oxidative stress, and the inflammatory process cause deterioration at the tissue level, primarily endothelial dysfunction (Iwakiri et al, 2008;Okuyucu et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

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The restorative effect of ascorbic acid on liver injury inducedby asymmetric dimethylarginine

Okuyucu¹,

Şalış²,

Alıcı³

et al. 2016

Turk J Biol

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Section: Discussionmentioning

confidence: 93%

“…We chose the time and dosage for this study based on the literature. (Alaçam et al, 2013;Okuyucu et al, 2015). Different doses and durations may be tested in future studies.…”

Section: Discussionmentioning

confidence: 99%

“…(Donpunha et al, 2011;Nagda and Bhatt, 2011;Alaçam et al, 2013). ADMA was dissolved in sterile 0.9% NaCl and each rat was given 0.2 mL.…”

Section: Study Groupsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

The restorative effect of ascorbic acid on liver injury inducedby asymmetric dimethylarginine

Okuyucu¹,

Şalış²,

Alıcı³

et al. 2016

Turk J Biol

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“…Asymmetric dimethylarginine (ADMA) is produced by methylation of arginine residues of the intracellular proteins (11,12). ADMA is an endogenous nitric oxide synthase (NOS) inhibitor that contributes to cardiovascular disease pathogenesis related to endothelial dysfunctions such as atherosclerosis, diabetes mellitus, and chronic renal disease (13,14).…”

Section: Introductionmentioning

confidence: 99%

Neopterin, homocysteine, and ADMA levels during and after urticaria attack

Tuncer¹,

Kaldirim²,

Eyi³

et al. 2015

Turk J Med Sci

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Background/aim: Urticaria is a vascular skin reaction characterized with papules and plaques. Neopterin is accepted as an immunologic marker and an indicator of activation of the immune system. Homocysteine and asymmetric dimethylarginine (ADMA) are the markers of increased vascular resistance. Alteration in vascular resistance has a role in the pathogenesis of urticaria. We aimed to investigate whether there is a relationship between urticaria and neopterin, homocysteine, or ADMA. Materials and methods:The study is designed as a prospective descriptive study and patients with a diagnosis of urticaria in the emergency department were included in the study. Demographic data and characteristics of the disease were recorded. Neopterin, homocysteine, and ADMA levels were measured both during and after urticaria attacks. All data were statistically analyzed. Results:The differences between neopterin levels measured during and after urticaria attacks were statistically significant (P < 0.001). The differences between homocysteine and ADMA levels measured during and after urticaria attacks were not statistically significant (P > 0.05). Conclusion:Our results indicate that neopterin levels in patients with urticaria attacks are increased and the level of neopterin is also a useful parameter in acute urticaria. Further studies should clarify whether homocysteine levels contribute to diagnosis of acute urticaria. However, no relation was found between ADMA and urticaria.

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The relationship of nitric oxide synthesis capacity, oxidative stress, and albumin-to-creatinine ratio in black and white men: the SABPA study

Mels

Huisman

Smith

et al. 2016

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Inadequate substrate availability and increased nitric oxide synthase inhibitor levels attenuate nitric oxide (NO) synthesis, whereas increased vascular oxidative stress may lead to inactivation of NO. We compared markers of NO synthesis capacity and oxidative stress in a bi-ethnic male population. Inter-relationships of ambulatory blood pressure and urinary albumin-to-creatinine ratio with NO synthesis capacity and oxidative stress markers were investigated. NO synthesis capacity markers (L-arginine, asymmetric dimethylarginine (ADMA), and symmetric dimethylarginine (SDMA)) and oxidative stress markers (serum peroxides, total glutathione, glutathione peroxidase (GPx), glutathione reductase (GR), superoxide dismutase (SOD), and catalase) were measured. Black men displayed higher blood pressure and albumin-to-creatinine ratio (all p < 0.001), while NO synthesis capacity was more favorable (higher L-arginine and lower ADMA (p ≤ 0.003)). Antioxidant enzyme activities were similar except for the redox status markers (GR activity and GR/GPx ratio), which were upregulated in black men (p < 0.001). In black men, ADMA was inversely related to GPx activity (R (2) = 0.15; β = -0.20; p = 0.050) and GPx/SOD ratio (R (2) = 0.24; β = -0.37; p < 0.001), but none of these markers related to blood pressure or albumin-to-creatinine ratio. In white men, albumin-to-creatinine ratio was positively associated with ADMA (R (2) = 0.18; β = 0.39; p < 0.001) while ADMA was inversely related to GR activity (R (2) = 0.26; β = -0.29; p = 0.002) and GR/GPx ratio (R (2) = 0.25; β = -0.28; p = 0.003). Black men with elevated blood pressure and albumin-to-creatinine ratio displayed a favorable NO synthesis capacity. This may be counteracted by increased inactivation of NO, although it was not linked to vascular or renal phenotypes. In white men, reduced NO synthesis capacity may lower NO bio-availability, thereby influencing the albumin-to-creatinine ratio.

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Does ADMA effect the oxidant/antioxidant balance in rats?

Cited by 8 publications

References 67 publications

The restorative effect of ascorbic acid on liver injury inducedby asymmetric dimethylarginine

The restorative effect of ascorbic acid on liver injury inducedby asymmetric dimethylarginine

Neopterin, homocysteine, and ADMA levels during and after urticaria attack

The relationship of nitric oxide synthesis capacity, oxidative stress, and albumin-to-creatinine ratio in black and white men: the SABPA study

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