Does aprotinin reduce lung reperfusion damage after cardiopulmonary bypass?✩

Rahman, Ali; Üstünda, Bilal; Burma, Oktay; Özercan, İbrahim Hanifı; Çekirdekçi, Ahmet; Bayar, Mustafa Kemal

doi:10.1016/s1010-7940(00)00518-2

Cited by 49 publications

(29 citation statements)

References 22 publications

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“…Aprotinin, a nonspecific serine protease inhibitor, has been extensively used in cardiac operations to reduce postoperative blood loss [4,[8][9][10][11][12]. In a recent report, neutrophil extravasation in association with ROS production, a necessary step in the inflammatory cascade, was inhibited by aprotinin in the mesenteric microcirculation [8], or during cardiopulmonary bypass [9].…”

Section: Introductionmentioning

confidence: 99%

Aprotinin attenuated ischemia–reperfusion injury in an isolated rat lung model after 18-hours preservation

Shimoyama

Tabuchi

Kojima

et al. 2005

European Journal of Cardio-Thoracic Surgery

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Section: Introductionmentioning

confidence: 99%

Aprotinin attenuated ischemia–reperfusion injury in an isolated rat lung model after 18-hours preservation

Shimoyama

Tabuchi

Kojima

et al. 2005

European Journal of Cardio-Thoracic Surgery

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“…7,23,24 In the control group, there was a statistically very significant (p<0.001) increase in the levels of MDA in the postoperative period but in the study group there was a decrease in the postoperative period, and was not statistically significant (p=0.569). Thus in the postoperative period, the MDA levels were significantly higher in the control group (p=0.033), implying an attenuated oxidative injury in the NAC treated group.…”

Section: Discussionmentioning

confidence: 89%

“…27 To counterbalance this sequence of events and diminish oxidative injury, several studies have investigated and recommended the use of antioxidant supplements, 8,9 viz. Steroids, 28 aprotinin, 23 pentoxiphylline, 29 N-acetylcysteine.…”

Section: Discussionmentioning

confidence: 99%

Effect of N - Acetylcysteine on Oxidative Stress in Patients Undergoing Off Pump Coronary Artery Bypass Grafting

Jalakandan¹,

Bhaskaran²,

Hiremath³

2015

jemds

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OBJECTIVE: Increasingly used Off Pump Coronary Artery Bypass Grafting (OPCABG) has significantly reduced the oxidative stress and decreased the inflammatory response associated with the use of Cardiopulmonary by Pass (CPB). However, OPCABG is associated with significant oxidative stress and its associated complications. This present study is a prospective, randomized, double blind investigating the effects of N-acetylcysteine (NAC), a potent anti-oxidant on oxidative stress in patients undergoing OPCABG. METHODS: Fifty patients undergoing elective OPCABG were randomized into two groups. Group A (n=25), the control group received 200ml of Normal saline immediately following induction, whereas Group B (n=25), the study group received 150mg/kg of NAC in 200ml of Normal saline at the corresponding time. At the end of surgery, all the patients were shifted to intensive care unit (ICU) and were extubated at the earliest possible time. Malondialdehyde (MDA), a marker of free radical injury and Glutathione (GSH) Levels were assayed from the 2 blood samples obtained (First sample immediately following induction and the second immediately after shifting to ICU). RESULTS: Demographic profile, pre-incision clinical and biochemical values were comparable in both the groups. At the end of surgery, MDA levels were significantly raised in control group (p<0.001) whereas its levels were maintained in study group (p<0.569). GSH levels were significantly decreased in control group (p<0.001) whereas its levels were significantly increased in study group (p<0.001). CONCLUSION: These results revealed that OPCABG was associated with significant oxidative response and the administration of N-Acetylcysteine attenuates this stress response by replenishing the Glutathione stores.

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“…It is presently widely used for minimizing perioperative blood loss in cardiac operations [16]. Experimental studies have shown that aprotinin, beyond its antiproteolytic membrane stabilizing property, decreases the release of lysosomal enzymes and increases intracellular adenine nucleotides [17, 18]. Bradykinin, kallidin and other kinins (known inflammatory mediators) have a high activity as permeability factors.…”

Section: Introductionmentioning

confidence: 99%

“…Bradykinin, kallidin and other kinins (known inflammatory mediators) have a high activity as permeability factors. While aprotinin inhibits bradykinin, it can also inhibit the production of superoxides and peroxides which are originated from human PMNLs [17]. …”

Section: Introductionmentioning

confidence: 99%

Effects of Vitamin E, Pentoxifylline and Aprotinin on Light-Induced Retinal Injury

Yılmaz

Aydemir²,

Özercan³

et al. 2007

Ophthalmologica

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Purpose: A considerable amount of clinical and experimental evidence exists suggesting the involvement of reactive oxygen species (ROS) in the etiology of light-induced retinal injury. The aim of this study was to investigate the protective role of vitamin E, pentoxifylline (PTX) and aprotinin against light-induced retinal injury in guinea pigs. Methods: Thirty adult male guinea pigs were divided into 5 groups of 6 animals each. The first group was used as control. The guinea pigs were kept in cyclic light for 2 weeks before the experiments. The animals were maintained in 12-hour light-dark cycles, before and after exposure to intense white fluorescent light, for as long as 12 h and then returned to cyclic light. Groups 3–5 received intraperitoneal injections of vitamin E, PTX and aprotinin, respectively. One eye of each animal was selected for histopathological evaluation and the other for biochemical assay. Retinal malondialdehyde (MDA) levels and the thickness of the outer nuclear layers were measured. Results: The compounds had the following relationships: vitamin E more than PTX more than aprotinin in preventing light-induced retinal damage. All 3 gave significant protection against the formation of MDA. Retinas of all 3 treatment groups had been protected from light-induced injury. Conclusion: The intraperitoneal vitamin E, PTX and aprotinin supplementations may strengthen the antioxidant defense system because of decreased ROS, and these agents may play a role in treating light-induced retinal injury.

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Does aprotinin reduce lung reperfusion damage after cardiopulmonary bypass?✩

Abstract: Results represented in our study indicate that addition of aprotinin (2 million units) into the prime solution during CPB can reduce lung reperfusion injury.

Cited by 49 publications

References 22 publications

Aprotinin attenuated ischemia–reperfusion injury in an isolated rat lung model after 18-hours preservation

Aprotinin attenuated ischemia–reperfusion injury in an isolated rat lung model after 18-hours preservation

Effect of N - Acetylcysteine on Oxidative Stress in Patients Undergoing Off Pump Coronary Artery Bypass Grafting

Effects of Vitamin E, Pentoxifylline and Aprotinin on Light-Induced Retinal Injury

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