Does B-Type Natriuretic Peptide Predict the New Onset of Hypertension?

Abstract

Increased B-type natriuretic peptide (BNP) expression precedes the development of hypertension in spontaneously hypertensive rats. We therefore tested the hypothesis that elevated plasma BNP levels predict the onset of hypertension in normotensive subjects. Japanese normotensive participants who were at our hospital for a yearly physical check-up (mean age 52.7 years, 35.9% women, n =5,026) were enrolled in the study. Blood pressure and BNP were measured at baseline and subjects were followed up for 5 years (median 1,114 d), with the endpoint being the development of hypertension. We evaluated the relationship between plasma BNP levels at baseline and the incidence of hypertension during the follow-up period.

Association between N-terminal pro B-type natriuretic peptide and day-to-day blood pressure and heart rate variability in a general population

“…Consistent with the previous findings [7,10,23], participants with high NT-proBNP levels had a high prevalence of hypertension (Table 1). On the contrary, the SD of home SBP and the SD of home HR was significantly associated with a high prevalence of NT-proBNP at least 125 pg/ml even in normotensives (Table 2).…”

“…Of those eligible, 1831 underwent a health check that year and 1626 (mean age, 61.6 AE 11.3 years; women, 66.7%) provided written, informed consent to participate in the present study. We excluded 271 individuals with no data about NT-proBNP, 655 who had taken less than 10 morning home BP or HR measurements [1], and 36 with ischemic heart disease or atrial fibrillation that seriously affects NT-proBNP levels [7][8][9][10]. The present study finally included data from 664 individuals.…”

“…Therefore, risk in patients with heart failure or acute coronary syndromes has been stratified using NT-proBNP [7][8][9][10], which is considered a more sensitive marker of cardiac dysfunction than BNP [11].…”

Use of Electrocardiography to Predict Future Development of Hypertension in the General Population

“…28 We previously reported that plasma BNP levels could be used to predict the new onset of hypertension in the general Japanese population. 29 However, the peptide level was not independently correlated with the incidence of hypertension because adjustment for baseline blood pressure abrogated the significant relationship between peptide level and incident hypertension. 29 In contrast, significant correlations were observed between Sokolow–Lyon voltage and the incidence of hypertension and between Cornell product and the incidence of hypertension, even after adjustment for important factors including blood pressure at baseline.…”

N-Terminal Pro-B-Type Natriuretic Peptide Is Not a Significant Predictor of Stroke Incidence After 5 Years ― The Ohasama Study ―

“…We excluded 422 participants from analysis because, at enrollment, they either did not have data on NT-proBNP (n=270), or had a history of cardiovascular disease or atrial fibrillation (AF; n=148), which considerably affects NT-proBNP, 14 or had NT-proBNP ≥1,000 pg/mL (n=4). Thus, the total number of participants analyzed was 1,198.…”