Does Baseline PTH Influence Recovery of Bone Mineral Density, Trabecular Bone Score and Bone Turnover Markers? A Prospective Study Following Curative PArathyroidectomy in Primary Hyperparathyroidism

Shetty, Shrinath; Cherian, Kripa Elizabeth; Shetty, Sahana; Kapoor, Nitin; Jebasingh, Felix; Cherian, Anish Jacob; Hephzibah, Julie; Chandramohan, Anuradha; John, Reetu Amirta; Asha, Hesarghatta S; Paul, Mazhuvanchary Jacob; Manipadam, Marie Therese; Abraham, Deepak Thomas; Nicolaï, Thomas; Paul, Thomas

doi:10.4158/ep-2020-0148

Cited by 3 publications

(2 citation statements)

References 25 publications

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“…In addition to BMD, microarchitectural alterations can significantly contribute to the fracture risk. The trabecular bone score (TBS) is a densitometric tool that evaluates pixel gray-level variations in lumbar spine DXA images, providing an indirect measure of the bone microarchitecture [ 18 , 19 , 20 , 21 , 22 , 23 , 24 ]. There is a paucity of literature on bone microarchitecture in women with morbid obesity and no available data from the South Asian region.…”

Section: Introductionmentioning

confidence: 99%

Trabecular Bone Score and Bone Mineral Density in Postmenopausal Women with Morbid Obesity—A Clinical Paradox

et al. 2021

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Obesity has long been considered to have a protective effect on bone, but specific complications in those with morbid obesity are known to have a detrimental impact on bone architecture. We aimed to study the bone microarchitecture (TBS—trabecular bone score) and bone mineral density (BMD) in postmenopausal women with morbid obesity compared to obese and non-obese age-matched women. Eighty-five consecutive postmenopausal women with morbid obesity (body mass index (BMI) ≥ 35 kg/m2) were enrolled and compared to age-matched obese (n = 80) and non-obese postmenopausal controls (n = 85). The BMD and TBS were assessed in all subjects using a Hologic-QDR 4500-W Discovery-A DXA scanner. The mean BMD (gm/cm2) at the femoral neck in women with morbid obesity was found to be significantly lower as compared to the age-matched postmenopausal obese controls (0.723 versus 0.762, p-value = 0.002). The BMD at the lumbar spine and hip showed similar trends but were not statistically significant. The bone microarchitecture was found to be significantly lower in those with morbid obesity (1.205) as compared to the other two groups (obesity 1.244; non-obese 1.228) (p < 0.013). Though obesity was associated with a better bone density and bone microarchitecture in postmenopausal women, a paradoxical lower value was seen in those with morbid obesity.

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Section: Introductionmentioning

confidence: 99%

Trabecular Bone Score and Bone Mineral Density in Postmenopausal Women with Morbid Obesity—A Clinical Paradox

et al. 2021

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“…Symptomatic disease is still commonly encountered in many Indian settings. [ 24 ] Hypercalcemia has also been shown to worsen preeclampsia. A hypercalcemic crisis may occur anytime during pregnancy or following delivery, once the placental transfer of calcium halts abruptly.…”

Section: Introductionmentioning

confidence: 99%

Functioning Endocrine Tumors in Pregnancy: Diagnostic and Therapeutic Challenges

Asha¹,

Cherian²,

Kapoor³

et al. 2021

Indian Journal of Endocrinology and Metabolism

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The occurrence of endocrine tumors in pregnancy poses several diagnostic and therapeutic challenges. Although rare, functioning tumors involving the pituitary, thyroid, adrenal, and pancreas are reported in the literature. Timely diagnosis and management of these tumors are essential as they might lead to adverse maternal and fetal outcomes if left untreated. This review is an attempt to characterize various functioning tumors that could occur in pregnancy, their clinical features, diagnosis, and management.

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What happens to the bone structure after normocalcemic primary hyperparathyroidism surgery?

Silla

Gómez-Ramírez

Valdazo-Gómez

et al. 2022

Surgery

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Does Baseline PTH Influence Recovery of Bone Mineral Density, Trabecular Bone Score and Bone Turnover Markers? A Prospective Study Following Curative PArathyroidectomy in Primary Hyperparathyroidism

Cited by 3 publications

References 25 publications

Trabecular Bone Score and Bone Mineral Density in Postmenopausal Women with Morbid Obesity—A Clinical Paradox

Trabecular Bone Score and Bone Mineral Density in Postmenopausal Women with Morbid Obesity—A Clinical Paradox

Functioning Endocrine Tumors in Pregnancy: Diagnostic and Therapeutic Challenges

What happens to the bone structure after normocalcemic primary hyperparathyroidism surgery?

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