Does Botulinum Toxin Therapy Improve Quality of Life in Patients with Facial Palsy?

Fuzi, Jordan; Taylor, Alon; Sideris, Anders; Meller, Catherine

doi:10.1007/s00266-020-01870-4

Cited by 20 publications

(5 citation statements)

References 25 publications

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“…Concerning the results of the post-injection questionnaires, few similar studies were found in the literature [ 14 , 30 , 32 , 33 , 34 , 35 , 37 ], and these always concerned small cohorts of patients. As for the House and Brackmann score, its simplicity and the large number of patients who were classified as grade III made it difficult to assess the efficacity of BoNT injections.…”

Section: Discussionmentioning

confidence: 99%

“…A systematic review was conducted by Luijmes et al [ 32 ] to investigate the effect of PFP on the QoL before and after different treatment modalities and reported two studies assessing the QoL after BoNT injections [ 33 , 34 ]. Another literature review conducted by Fuzi et al [ 35 ] found six articles assessing the quality of life after BoNT injection [ 14 , 26 , 33 , 34 , 36 , 37 ]. These studies highlighted an improvement in the QoL after BoNT injection.…”

Section: Introductionmentioning

confidence: 99%

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Impact of Botulinum Toxin Injections on Quality of Life of Patients with Long-Standing Peripheral Facial Palsy

Amar,

Tankere,

Picard

et al. 2024

Toxins

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(1) Background: Sequels of facial palsy lead to major psychosocial repercussions, disrupting patients’ quality of life (QoL). Botulinum toxin (BoNT) injections can permit us to treat long-standing facial palsy, improving facial symmetry and functional signs including synkinesis and contractures. (2) Methods: The main aim of this study was to assess the evolution of the QoL for patients with long-standing facial palsy before, at 1 month, and at 4 months after BoNT injections by using three questionnaires (HFS-30, FaCE, and HAD). The other goals were to find clinical factors associated with the improvement in the QoL and to assess the HFS-30 questionnaire for patients with unilateral facial palsy (3) Results: Eighty-eight patients were included in this study. There was a statistically significant improvement in QoL at 1 month after injections, assessed using the three questionnaires. This improvement was sustained at 4 months after the injections, with a statistically significant difference for the HFS-30 and FaCE questionnaires. (4) Conclusions: This study showed that the BoNT injections lead to a significant increase in the QoL of patients with unilateral facial palsy. This improvement is sustained 4 months after the injections.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Impact of Botulinum Toxin Injections on Quality of Life of Patients with Long-Standing Peripheral Facial Palsy

Amar,

Tankere,

Picard

et al. 2024

Toxins

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show abstract

“…Facial muscle dysfunction impairs the patient’s quality of life on multiple levels, affecting the oral functionality and mimetic communication [ 1 , 3 , 55 ]. Thus, effective, reproduceable, and unbiased diagnostic procedures lay the groundwork for introducing targeted therapy concepts in an early post-onset stage.…”

Section: Discussionmentioning

confidence: 99%

Using High-Resolution Ultrasound to Assess Post-Facial Paralysis Synkinesis—Machine Settings and Technical Aspects for Facial Surgeons

et al. 2022

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Background: Synkinesis of the facial musculature is a detrimental sequalae in post-paralytic facial palsy (PPFP) patients. Detailed knowledge on the technical requirements and device properties in a high-resolution ultrasound (HRUS) examination is mandatory for a reliable facial muscle assessment in PPFP patients. We therefore aimed to outline the key steps in a HRUS examination and extract an optimized workflow schema. Methods: From December 2020 to April 2021, 20 patients with unilateral synkinesis underwent HRUS. All HRUS examinations were performed by the first author using US devices with linear multifrequency transducers of 4–18 MHz, including a LOGIQ E9 and a LOGIQ S7 XDclear (GE Healthcare; Milwaukee, WI, USA), as well as Philips Affinity 50G (Philips Health Systems; Eindhoven, the Netherlands). Results: Higher-frequency and multifrequency linear probes ≥15 MHz provided superior imaging qualities. The selection of the preset program Small Parts, Breast or Thyroid was linked with a more detailed contrast of the imaging morphology of facial tissue layers. Frequency (Frq) = 15 MHz, Gain (Gn) = 25–35 db, Depth (D) = 1–1.5 cm, and Focus (F) = 0.5 cm enhanced the image quality and assessability. Conclusions: An optimized HRUS examination protocol for quantitative and qualitative facial muscle assessments was proposed.

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“…In a more comprehensive study, 6 studies were scrutinized in a reviewed by Dr. J. Fuzi, and ultimately found that there is a positive trend in the improvement of facial paresis through the administration of botulinum toxin type A. [27] Concluding Remarks As hypothesized, the administration of botulinum toxin type A proved to be efficient and showed major improvements in the mobility of facial muscles of patients suffering from Bell's palsy. In cases of toxin resistance to BtA, botulinum toxin types B, C, and F can also be administered to treat peripheral nerve palsies.…”

Section: Evaluation Of Risks Of Treating Peripheral Facial Paralysis ...mentioning

confidence: 98%

Bell’s palsy’s viral pathogenicity and the use of botulinum toxin type A as treatment

MELARA

Chandra

2022

Journal of Contemporary Medicine

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Bell'in felci, kraniyal sinir VII'nin iltihaplanmasının ortak adıdır. Kendine özgü genikulat ganglion iltihabı idiyopatiktir ve hemifasiyal felce neden olur. Bu felçten muzdarip olan hastaların semptomları 3 hafta ile 3 ay arasında kaybolabilir. Yüz felci devam eden bazı hastalar için botulinum toksin tip A etkili bir tedavi olabilir. Kas felcinin şiddetine göre botoksun yanı sıra ameliyat, steroid ve antiviral tedavi gibi farklı tedaviler sunulabilir. Bu derleme makalesinin amacı, viral patojenlerin fasiyal sinir iltihabının aktivasyonu ile olası ilişkisine ve Bell felçli hastaların tedavi olarak botoks tip-A'dan nasıl yararlanabileceğine dalmaktır.

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Does Botulinum Toxin Therapy Improve Quality of Life in Patients with Facial Palsy?

Cited by 20 publications

References 25 publications

Impact of Botulinum Toxin Injections on Quality of Life of Patients with Long-Standing Peripheral Facial Palsy

Impact of Botulinum Toxin Injections on Quality of Life of Patients with Long-Standing Peripheral Facial Palsy

Using High-Resolution Ultrasound to Assess Post-Facial Paralysis Synkinesis—Machine Settings and Technical Aspects for Facial Surgeons

Bell’s palsy’s viral pathogenicity and the use of botulinum toxin type A as treatment

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