Does capsaicin relieve the pain of diabetic neuropathy?

Chad, David A.; Aronin, Neil; Lundstrom, Ruth; McKeon, Peter R.; Ross, David R; Molitch, Mark E.; Schipper, Hy M.; Stall, G.; Dyess, Eric M.; Tarsy, Daniel

doi:10.1016/0304-3959(90)91153-a

Cited by 78 publications

(28 citation statements)

References 7 publications

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“…Four studies identified (Basha 1991;Donofrio 1991;Scheffler 1991;Tandan 1992) were reports of parts of a multicentre study (CSG 1992), only one of which (Tandan 1992, 22 participants) provided any additional data. Eleven other studies were excluded after reading the full report (Chad 1990;Fusco 1992;McCarty 1994;McCleane 2000;Paice 2000;Peikert 1991;Pfeifer 1993;Robbins 1998;Vickers 1998;Watson 1988;Watson 1989). Reasons for exclusion are in the 'Characteristics of excluded studies' table.…”

Section: Description Of Studiesmentioning

confidence: 99%

“…Similarly, investigator or physician reported outcomes do not reliably correspond to patient outcomes. In particular, four studies of 4 weeks' duration were excluded (Chad 1990;McCarty 1994;McCleane 2000;Paice 2000). These studies enrolled 329 participants, 90 of whom were treated with 0.075% capsaicin, and 21 with 0.025% capsaicin.…”

Section: Overall Completeness and Applicability Of Evidencementioning

confidence: 99%

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Topical capsaicin for chronic neuropathic pain in adults

Derry¹,

Moore²,

McQuay³

et al. 2008

Cochrane Database of Systematic Reviews

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Background-Topical creams with capsaicin are used to treat pain from a wide range of chronic conditions including neuropathic pain. Following application to the skin capsaicin causes enhanced sensitivity to noxious stimuli, followed by a period with reduced sensitivity and, after repeated applications, persistent desensitisation. There is uncertainty about the efficacy and tolerability of capsaicin for treating painful chronic neuropathies.

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Section: Description Of Studiesmentioning

confidence: 99%

Section: Overall Completeness and Applicability Of Evidencementioning

confidence: 99%

Topical capsaicin for chronic neuropathic pain in adults

Derry¹,

Moore²,

McQuay³

et al. 2008

Cochrane Database of Systematic Reviews

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“…32,36 -38 Two reported significant improvements in all three outcome measures at 8 weeks, 32,37 whereas two reported significant improvements in only one outcome measure at 4 to 8 weeks. 36,38 In most trials, patients were more likely to experience burning after application with capsaicin (60% to 63%) compared with placebo (17% to 20%), which could have affected blinding. The largest trial also had a significantly higher dropout Diabetic Peripheral Neuropathy 53 on 28 April 2019 by guest.…”

Section: Clinical Studiesmentioning

confidence: 99%

Botanicals and Dietary Supplements in Diabetic Peripheral Neuropathy

Halat¹,

Dennehy²

2003

The Journal of the American Board of Family Medicine

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Background: Many persons use botanicals and dietary supplements for chronic conditions that do not respond to traditional Western medications. Tricyclic antidepressants, a common treatment option for diabetic neuropathy, can have many side effects and are a poor choice in certain populations (eg, the elderly). As such, patients might turn to botanicals and dietary supplements, not realizing that these products are not well regulated.Methods: This article reviews botanicals and dietary supplements that have been involved in randomized controlled trials (RCTs) for diabetic neuropathy. We searched MEDLINE for English-language literature dating from 1966 to April 2001 using the following subject headings: (1) diabetes and botanical, herb, and supplement, (2) neuropathy and botanical, herb, and supplement, and (3) diabetic neuropathy and botanical, herb, and supplement.Results: Our search found agents that might improve symptoms of neuropathy (eg, evening primrose oil, alpha-lipoic acid, capsaicin) without affecting glucose control. Botanicals and dietary supplements involved in only one RCT or associated with little clinical benefit were reviewed in brief.Conclusions: Evening primrose oil, alpha-lipoic acid, and capsaicin have received the greatest attention for their use in diabetic neuropathy, but further studies are needed to confirm their efficacy. Patients using these products need to be informed of potential drug interactions and side effects.

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“…Capsaicin has been investigated as a topical application for diabetic [325][326][327][328][329] and HIV peripheral neuropathy [330][331][332]. The majority of studies have been conducted on diabetes PN with most resulting in statistical significance [325][326][327][328][329].…”

Section: -114mentioning

confidence: 99%

“…The majority of studies have been conducted on diabetes PN with most resulting in statistical significance [325][326][327][328][329]. The results indicate that capsaicin cream may provide relief for chronic, intractable pain and reduce dependence on opioids however the main side effect of burning at the site of application may be of concern [329].…”

Section: -114mentioning

confidence: 99%

A pilot clinical trial assessing the efficacy and safety of supplementation with a B complex vitamin to reduce the incidence of chemotherapy induced peripheral neuropathy in patients diagnosed with a malignancy

Schloss¹

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Does capsaicin relieve the pain of diabetic neuropathy?

Cited by 78 publications

References 7 publications

Topical capsaicin for chronic neuropathic pain in adults

Topical capsaicin for chronic neuropathic pain in adults

Botanicals and Dietary Supplements in Diabetic Peripheral Neuropathy

A pilot clinical trial assessing the efficacy and safety of supplementation with a B complex vitamin to reduce the incidence of chemotherapy induced peripheral neuropathy in patients diagnosed with a malignancy

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