Does celiac disease occur in Afro‐derived Brazilian populations?

Almeida, Rodrigo Coutinho de; Gandolfi, Lenora; Klautau‐Guimarães, Maria de Nazaré; Ferrari, Íris; Sousa, Sandra Maria Zákia Lian; Abe‐Sandes, Kiyoko; Barbosa, Ana Angélica Leal; Simões, Aguinaldo Luíz; Pratesi, Riccardo; Oliveira, Silviene Fabiana de

doi:10.1002/ajhb.22271

Cited by 15 publications

(19 citation statements)

References 15 publications

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“…Of the five patients with definite CD, four were African and one was Indian; median age (IQR) was 24 years; and median body mass index 27.3 kg/m 2 . All the patients were asymptomatic.…”

Section: Resultsmentioning

confidence: 99%

“…The effect of ethnicity on CD prevalence remains unclear, but weak evidence has suggested that CD is rare in African origin populations . A Brazilian study that screened 10 Afro‐derived communities in the general population found that all 860 individuals tested negative for EMA, supporting a low prevalence of CD .…”

Section: Discussionmentioning

confidence: 99%

“…The effect of ethnicity on CD prevalence remains unclear, but weak evidence has suggested that CD is rare in African origin populations. 20,21 A Brazilian study that screened 10 Afro-derived communities in the general population found that all 860 individuals tested negative for EMA, supporting a low prevalence of CD. 20 A study that screened 34 African-American children with T1DM for CD in inner city Brooklyn found no cases despite 28 children having a predisposing HLA haplotype (HLA DQ2 or DQ8).…”

Section: Discussionmentioning

confidence: 99%

“…20,21 A Brazilian study that screened 10 Afro-derived communities in the general population found that all 860 individuals tested negative for EMA, supporting a low prevalence of CD. 20 A study that screened 34 African-American children with T1DM for CD in inner city Brooklyn found no cases despite 28 children having a predisposing HLA haplotype (HLA DQ2 or DQ8). 26 Although the numbers in our study were small, no ethnic-specific difference in the prevalence of CD was observed when African patients were compared with the rest of the cohort.…”

Section: Discussionmentioning

confidence: 99%

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Prevalence and characteristics of celiac disease in South African patients with type 1 diabetes mellitus: Results from the Durban Diabetes and Celiac Disease Study

Paruk

Naidoo

Pirie

et al. 2019

J of Gastro and Hepatol

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Background and Aim The aim of this study was to assess the prevalence and characteristics of celiac disease (CD) in all patients with type 1 diabetes mellitus attending a tertiary adult diabetes clinic in Durban, South Africa. Methods This was a cross‐sectional observational study that screened 202 patients; of these, 56.4% were African (Black), 31.7% Asian Indian, 4.5% White, and 7.4% mixed race. Demographic data, symptoms, and anthropometry were documented. Blood tests included anti‐tissue transglutaminase antibody (tTG), anti‐endomysial antibody (EMA), and anti‐gliadin antibody (AGA). Endoscopy and duodenal biopsy were performed in patients with celiac antibodies. Diagnosis of CD was based on the modified Marsh classification. Results Mean age and mean duration of diabetes were 26.4 ± 11.4 and 10.7 ± 9.1 years, respectively. Celiac antibodies were found in 65 (32.2%) patients: EMA 7.4%, tTG immunoglobulin A (IgA) 8.4%, tTG immunoglobulin G 1.9%, AGA IgA 18.3%, and AGA immunoglobulin G 21.8%. Histological evidence of CD was found in 5.9% (n = 12/202): 2.5% were classed as definite CD (Marsh 3) and 3.4% as potential CD (Marsh 1). None of the patients with CD were symptomatic. The sensitivity of AGA IgA, EMA, and tTG IgA antibodies for detecting histologically proven CD was 66.7%, 50.0%, and 41.7%, respectively. Conclusion The prevalence of CD was similar to reports from western countries. No ethnic specific differences were noted. CD was silent in all patients in this study. The sensitivity of EMA and tTG antibodies was poor and merits further evaluation as screening tools for CD in South African patients with type 1 diabetes mellitus.

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“…Of the five patients with definite CD, four were African and one was Indian; median age (IQR) was 24 years; and median body mass index 27.3 kg/m 2 . All the patients were asymptomatic.…”

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Prevalence and characteristics of celiac disease in South African patients with type 1 diabetes mellitus: Results from the Durban Diabetes and Celiac Disease Study

Paruk

Naidoo

Pirie

et al. 2019

J of Gastro and Hepatol

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“…Pernambuco (28) 2012 8 11.7 North east (African origins) (2) 2012 0 0 Mangueirinha (Kaingang & Guarani) (43) 2010 0 0…”

Section: Uk and Irelandmentioning

confidence: 99%

COELIAC DISEASE IN CENTRAL AND SOUTH AMERICA: time for a concerted approach to its epidemiology

Farrukh¹,

Mayberry²

2015

Arq. Gastroenterol.

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Central and South America offer an opportunity to resolve some of the current controversies that surround the epidemiology of celiac disease. Through a concerted action which brings together clinicians, researchers and patients there is an opportunity to establish robust data sets which will allow detailed analysis of environmental and genetic factors. In this review available data from the continent together with data from Spain and Italy are drawn together to give a current picture in the hope that it will stimulate further research.

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Measuring attack on self: The need for field‐friendly methods development and research on autoimmunity in human biology

Cepon-Robins

2020

American J Hum Biol

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Background: Autoimmune and inflammatory disorder (AIID) prevalence appears to be increasing in all but the world's poorest regions and countries. Autoimmune diseases occur when there is a breakdown in processes that regulate inflammation and self-recognition by immune cells. Very few field-based studies have been conducted among Indigenous populations and underserved communities with limited access to medical care. This is due, in part, to the fact that autoimmune diseases are difficult to diagnose, even in clinical settings. In remote field settings these difficulties are compounded by the absence of infrastructure necessary for sample storage and analysis, and the lack of hospital/clinic access for more invasive diagnostic procedures. Because of these limitations, little is known about the prevalence of autoimmunity outside wealthy regions and clinical settings. Aims: The present paper discusses why AIID are of critical importance in human biology research and why more work needs to be devoted to validating, testing, and utilizing methods for detecting autoantibodies and other biomarkers related to autoimmunity in field-friendly, minimally invasivelycollected samples. This paper reviews some of the methods used to diagnose AIIDs in clinical settings, and highlights methods that have been used in studies within human biology and related fields, emphasizing the invasiveness of specific methods and their feasibility in remote field settings. Discussion and Conclusions: Risk for AIID is affected by several reproductive, dietary, environmental, and genetic factors. Human biologists have unique perspectives that they can bring to autoimmunity research, and more populationbased studies on autoimmunity are needed within these and related fields.

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Does celiac disease occur in Afro‐derived Brazilian populations?

Abstract: Our data suggests a low prevalence of celiac disease in African-derived Brazilian populations.

Cited by 15 publications

References 15 publications

Prevalence and characteristics of celiac disease in South African patients with type 1 diabetes mellitus: Results from the Durban Diabetes and Celiac Disease Study

Prevalence and characteristics of celiac disease in South African patients with type 1 diabetes mellitus: Results from the Durban Diabetes and Celiac Disease Study

COELIAC DISEASE IN CENTRAL AND SOUTH AMERICA: time for a concerted approach to its epidemiology

Measuring attack on self: The need for field‐friendly methods development and research on autoimmunity in human biology

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