Does Corneal Hysteresis Correlate with Endothelial Cell Density?

Budak, Berna Akova; Kıvanç, Sertaç Argun

doi:10.12659/msm.893589

Cited by 4 publications

(4 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The biomechanical properties of cornea as CH and CRF are strongly correlated with CCT [4–6, 18]. The results of this study were in accordance with the literature.…”

Section: Discussionsupporting

confidence: 90%

Relationship among Corneal Biomechanics, Anterior Segment Parameters, and Geometric Corneal Parameters

Çevik

Kıvanç

Budak

et al. 2016

Journal of Ophthalmology

Self Cite

View full text Add to dashboard Cite

Purpose. To investigate the relationship between corneal biomechanical parameters, anterior segment parameters, and geometric corneal parameters in a healthy Caucasian group. Methods. This retrospective study included the healthy eyes with best corrected visual acuity of at least 20/40 of 122 Caucasian subjects. The anterior segment parameters and geometric corneal parameters such as corneal volume, central corneal thickness, horizontal and vertical corneal radii, anterior and posterior steep, and flat keratometric values were measured with a Scheimpflug camera. The biomechanical properties were measured with Ocular Response Analyzer. Results. One hundred and twenty-two healthy Caucasian subjects (67 males, 55 females) with a mean age of 45.32 ± 20.23 were enrolled. Both corneal hysteresis and corneal resistance factor were positively correlated with CCT (r = 0.529, p < 0.001; r = 0.638, p < 0.001) and CV (r = 0.635, p < 0.001; r = 0.579, p < 0.001) and negatively correlated with age (r = −0.373, p < 0.001; r = −0.249, p < 0.001). Both in age-gender and multivariate models, CH and CRF had statistically significant negative association with the posterior steep K value. Conclusions. CH and CRF are negatively correlated with posterior steep and average posterior K values.

show abstract

“…The biomechanical properties of cornea as CH and CRF are strongly correlated with CCT [4–6, 18]. The results of this study were in accordance with the literature.…”

Section: Discussionsupporting

confidence: 90%

Relationship among Corneal Biomechanics, Anterior Segment Parameters, and Geometric Corneal Parameters

Çevik

Kıvanç

Budak

et al. 2016

Journal of Ophthalmology

Self Cite

View full text Add to dashboard Cite

show abstract

“…Our study has found statistically significant, moderate-to-strong correlations between CH and CRF and endothelial cell count and variability. However, to the best of our knowledge, these findings differ from those in the literature, where no significant correlation has been found between biomechanical and endothelial corneal parameters in healthy volunteers [ 39 ] or in patients with cataract [ 40 ]. As the level of corneal hydration, which is regulated by the endothelial pump function, may influence corneal biomechanics [ 39 ], more studies are needed in order to identify the factors that modulate the relationship between CH, CRF and endothelium parameters.…”

Section: Discussioncontrasting

confidence: 99%

Particular Anatomy of the Hyperopic Eye and Potential Clinical Implications

Marinescu,

Dascalescu,

Constantin

et al. 2023

Medicina

View full text Add to dashboard Cite

Background and Objectives: Hyperopia is a refractive error which affects cognitive and social development if uncorrected and raises the risk of primary angle-closure glaucoma (PACG). Materials and Methods: The study included only the right eye—40 hyperopic eyes in the study group (spherical equivalent (SE) under pharmacological cycloplegia over 0.50 D), 34 emmetropic eyes in the control group (SE between −0.50 D and +0.50 D). A complete ophthalmological evaluation was performed, including autorefractometry to measure SE, and additionally we performed Ocular Response Analyser: Corneal Hysteresis (CH), Corneal Resistance Factor (CRF); specular microscopy: Endothelial cell density (CD), Cell variability (CV), Hexagonality (Hex), Aladdin biometry: Anterior Chamber Depth (ACD), Axial Length (AL), Central Corneal Thickness (CCT). IBM SPSS 26 was used for statistical analysis. Results: The mean age of the entire cohort was 22.93 years (SD ± 12.069), 66.22% being female and 33.78% male. The hyperopic eyes had significantly lower AL, ACD, higher SE, CH, CRF. In the hyperopia group, there are significant, negative correlations between CH and AL (r −0.335), CRF and AL (r −0.334), SE–AL (r −0.593), ACD and CV (r −0.528), CV and CRF (r −0.438), CH (r −0.379), and positive correlations between CCT and CH (r 0.393) or CRF (r 0.435), CD and ACD (r 0.509) or CH (0.384). Age is significantly, negatively correlated with ACD (r −0.447), CH (r −0.544), CRF (r −0.539), CD (r −0.546) and positively with CV (r 0.470). Conclusions: Our study suggests a particular biomechanical behavior of the cornea in hyperopia, in relation with morphological and endothelial parameters. Moreover, the negative correlation between age and ACD suggests a shallower anterior chamber as patients age, increasing the risk for PACG.

show abstract

“…The recent studies (since 2015), which have analyzed the mechanical corneal properties in relation with the cell density of the corneal endothelium, have been unable to show a statistically significant correlation [ 35 , 36 ].…”

Section: Discussionmentioning

confidence: 99%

Correlations between corneal biomechanics and specular microscopy in patient with cataract

Iancu

Bujor

Iliuţă

et al. 2020

rjo

View full text Add to dashboard Cite

This study aimed to analyze the connection between corneal biomechanics (corneal hysteresis, CH) and endothelial cell density of cornea (mean endothelial cell density, MCD) in patients diagnosed with cataract. This retrospective, observational study was performed in the Ophthalmology Clinic of the University Emergency Hospital in Bucharest. Of 60 patients (120 eyes) with cataract, who were included in this study, we analyzed the CH values obtained using with the Ocular Response Analyzer (ORA) and the MCD values obtained using the specular microscopy. The study groups comprised both men and women with ages ranging from 45 to 63 years. Patients were divided into three study groups according to CH values. In each batch, the CH values obtained with the Ocular Response Analyzer (ORA) were correlated with age, gender and MCD, then the subgroups were compared. All the data gathered showed no correlation to be statistically significant regarding the biomechanical properties of the cornea and the corneal endothelial cell density in patients with cataract.

show abstract

Does Corneal Hysteresis Correlate with Endothelial Cell Density?

Cited by 4 publications

References 26 publications

Relationship among Corneal Biomechanics, Anterior Segment Parameters, and Geometric Corneal Parameters

Relationship among Corneal Biomechanics, Anterior Segment Parameters, and Geometric Corneal Parameters

Particular Anatomy of the Hyperopic Eye and Potential Clinical Implications

Correlations between corneal biomechanics and specular microscopy in patient with cataract

Contact Info

Product

Resources

About