Does endogenous cholecystokinin modulate alcohol intake?

Ballaz, Santiago; Espinosa, Nicole; Bourin, Michel

doi:10.1016/j.neuropharm.2021.108539

Cited by 13 publications

(8 citation statements)

References 97 publications

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“… 16 CCK regulates feeding, learning, memory, and nociception by binding to two G‐protein receptors: CCK1 and CCK2. 17 , 18 , 19 CCK has numerous isoforms, including CCK‐58, CCK‐22, CCK‐8, CCK‐5, and CCK‐4. 20 CCK‐8 is one of the most abundant isoforms and mediates the biological functions of CCK in the CNS.…”

Section: Introductionmentioning

confidence: 99%

Cholecystokinin octapeptide improves hippocampal glutamatergic synaptogenesis and postoperative cognition by inhibiting induction of A1 reactive astrocytes in aged mice

Chen

Yang

et al. 2021

CNS Neurosci Ther

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Section: Introductionmentioning

confidence: 99%

Cholecystokinin octapeptide improves hippocampal glutamatergic synaptogenesis and postoperative cognition by inhibiting induction of A1 reactive astrocytes in aged mice

Chen

Yang

et al. 2021

CNS Neurosci Ther

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“…This neuropeptide modulates various transmitter systems in the brain including dopamine ( Rotzinger et al, 2002 ), opioids ( Hebb et al, 2005 ), glutamate ( Nguyen et al, 2020 ), GABA ( Freund and Katona, 2007 ), and serotonin ( Grignaschi et al, 1993 ). Most notably, CCK is implicated in modulating the various positive and negative features of AUD ( Ballaz et al, 2021 ).…”

Section: Cholecystokininmentioning

confidence: 99%

“…The dorsal vagal complex (DVC) plays a critical role in relaying interoceptive sensory information to higher order brain regions as well as mediating central output to abdominal viscera via the utilization of various neurotransmitter and neuropeptide systems ( Rinaman, 2011 ; Browning et al, 2017 ; Browning and Carson, 2021 ). Many of these same neurotransmitters and neuropeptides have also been implicated in various aspects of alcohol use disorder (AUD) ( Bodnar, 2013 ; Haass-Koffler et al, 2018 ; Jerlhag, 2018 ; Genders et al, 2020 ; Torruella-Suárez and McElligott, 2020 ; Ballaz et al, 2021 ). The DVC, therefore, may be involved in AUD through its various roles in interoceptive functions and signaling systems, but previous research has not fully investigated this hypothesis.…”

Section: Introductionmentioning

confidence: 99%

Involvement of the Dorsal Vagal Complex in Alcohol-Related Behaviors

Keller

Hajnal

Browning

et al. 2022

Front. Behav. Neurosci.

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The neurobiological mechanisms that regulate the development and maintenance of alcohol use disorder (AUD) are complex and involve a wide variety of within and between systems neuroadaptations. While classic reward, preoccupation, and withdrawal neurocircuits have been heavily studied in terms of AUD, viable treatment targets from this established literature have not proven clinically effective as of yet. Therefore, examination of additional neurocircuitries not classically studied in the context of AUD may provide novel therapeutic targets. Recent studies demonstrate that various neuropeptides systems are important modulators of alcohol reward, seeking, and intake behaviors. This includes neurocircuitry within the dorsal vagal complex (DVC), which is involved in the control of the autonomic nervous system, control of intake of natural rewards like food, and acts as a relay of interoceptive sensory information via interactions of numerous gut-brain peptides and neurotransmitter systems with DVC projections to central and peripheral targets. DVC neuron subtypes produce a variety of neuropeptides and transmitters and project to target brain regions critical for reward such as the mesolimbic dopamine system as well as other limbic areas important for the negative reinforcing and aversive properties of alcohol withdrawal such as the extended amygdala. This suggests the DVC may play a role in the modulation of various aspects of AUD. This review summarizes the current literature on neurotransmitters and neuropeptides systems in the DVC (e.g., norepinephrine, glucagon-like peptide 1, neurotensin, cholecystokinin, thyrotropin-releasing hormone), and their potential relevance to alcohol-related behaviors in humans and rodent models for AUD research. A better understanding of the role of the DVC in modulating alcohol related behaviors may lead to the elucidation of novel therapeutic targets for drug development in AUD.

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“…Nevertheless, CCK1 and CCK2 receptor blockade reduced alcohol drinking and anxiety during alcohol withdrawal, respectively, hinting at unique receptor-dependent central functions of CCK in regulating motivation for alcohol consumption and related emotional behaviors [ 12 , 77 , 78 ]. More recently, Ballaz et al thoroughly reviewed the hypothesis that endogenous CCK regulates alcohol intake, perhaps through interactions with DA, 5-HT, and endogenous opioid systems [ 3 ].…”

Section: Introductionmentioning

confidence: 99%