Does equol production determine soy endocrine effects?

Shor, Dana Ben-Ami; Sathyapalan, Thozhukat; Atkin, Stephen L.; Thatcher, Natalie J

doi:10.1007/s00394-012-0331-7

Cited by 51 publications

(54 citation statements)

References 133 publications

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“…Estrogens with intermediate strength supported MCF-7 cell proliferation at 1-100 nM and included two representative industrial chemicals BPA and p-nonylphenol (PNP) (1,19). The isoflavone phytoestrogens genistein and daidzein, which require metabolic activation for their full-strength estrogenic actions (20), were weak estrogens that supported MCF-7 cell proliferation at 0.1-10 μM. Based on these results, we selected estrogen concentrations for which the seed transcriptomal profiles were determined (indicated in Fig.…”

Section: Generation Of Computational Models Of Dose-dependent Transcrmentioning

confidence: 99%

Expressomal approach for comprehensive analysis and visualization of ligand sensitivities of xenoestrogen responsive genes

Shioda

Rosenthal

Coser

et al. 2013

Proc. Natl. Acad. Sci. U.S.A.

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Although biological effects of endocrine disrupting chemicals (EDCs) are often observed at unexpectedly low doses with occasional nonmonotonic dose-response characteristics, transcriptomewide profiles of sensitivities or dose-dependent behaviors of the EDC responsive genes have remained unexplored. Here, we describe expressome analysis for the comprehensive examination of dosedependent gene responses and its applications to characterize estrogen responsive genes in MCF-7 cells. Transcriptomes of MCF-7 cells exposed to varying concentrations of representative natural and xenobiotic estrogens for 48 h were determined by microarray and used for computational calculation of interpolated approximations of estimated transcriptomes for 300 doses uniformly distributed in log space for each chemical. The entire collection of these estimated transcriptomes, designated as the expressome, has provided unique opportunities to profile chemical-specific distributions of ligand sensitivities for large numbers of estrogen responsive genes, revealing that at low concentrations estrogens generally tended to suppress rather than to activate transcription. Gene ontology analysis demonstrated distinct functional enrichment between high-and low-sensitivity estrogen responsive genes, supporting the notion that a single EDC chemical can cause qualitatively distinct biological responses at different doses. Expressomal heatmap visualization of dose-dependent induction of Bisphenol A inducible genes showed a weak gene activation peak at a very low concentration range (ca. 0.1 nM) in addition to the main, strong gene activation peak at and above 100 nM. Thus, expressome analysis is a powerful approach to understanding the EDC dose-dependent dynamic changes in gene expression at the transcriptomal level, providing important information on the overall profiles of ligand sensitivities and nonmonotonic responses.

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Section: Generation Of Computational Models Of Dose-dependent Transcrmentioning

confidence: 99%

Expressomal approach for comprehensive analysis and visualization of ligand sensitivities of xenoestrogen responsive genes

Shioda

Rosenthal

Coser

et al. 2013

Proc. Natl. Acad. Sci. U.S.A.

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“…Equol is a metabolite produced in the gastrointestinal tract by bacterial metabolism of daidzein, and there is some evidence that equol has higher hormonal activity that genistein and daidzein 30, 3130, 32 but its role in humans remains unclear.…”

Section: Discussionmentioning

confidence: 99%

“…In vitro and animal studies have shown that equol has anti‐androgenic and anti‐proliferative properties in the prostate,30, 32 but its role in humans remains unclear. Equol production varies between individuals, and the term equol‐producers refers to people who produce equol after consuming isoflavones; therefore it may be possible that the health benefits of soya‐based diets are greater in equol‐producers than in equol non‐producers 33…”

Section: Discussionmentioning

confidence: 99%

Circulating isoflavone and lignan concentrations and prostate cancer risk: a meta‐analysis of individual participant data from seven prospective studies including 2,828 cases and 5,593 controls

Pérez-Cornago

Appleby

Boeing

et al. 2018

Intl Journal of Cancer

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Phytoestrogens may influence prostate cancer development. This study aimed to examine the association between prediagnostic circulating concentrations of isoflavones (genistein, daidzein, equol) and lignans (enterolactone and enterodiol) and the risk of prostate cancer. Individual participant data were available from seven prospective studies (two studies from Japan with 241 cases and 503 controls and five studies from Europe with 2,828 cases and 5,593 controls). Because of the large difference in circulating isoflavone concentrations between Japan and Europe, analyses of the associations of isoflavone concentrations and prostate cancer risk were evaluated separately. Prostate cancer risk by study‐specific fourths of circulating concentrations of each phytoestrogen was estimated using multivariable‐adjusted conditional logistic regression. In men from Japan, those with high compared to low circulating equol concentrations had a lower risk of prostate cancer (multivariable‐adjusted OR for upper quartile [Q4] vs. Q1 = 0.61, 95% confidence interval [CI] = 0.39–0.97), although there was no significant trend (OR per 75 percentile increase = 0.69, 95 CI = 0.46–1.05, p trend = 0.085); Genistein and daidzein concentrations were not significantly associated with risk (ORs for Q4 vs. Q1 = 0.70, 0.45–1.10 and 0.71, 0.45–1.12, respectively). In men from Europe, circulating concentrations of genistein, daidzein and equol were not associated with risk. Circulating lignan concentrations were not associated with the risk of prostate cancer, overall or by disease aggressiveness or time to diagnosis. There was no strong evidence that prediagnostic circulating concentrations of isoflavones or lignans are associated with prostate cancer risk, although further research is warranted in populations where isoflavone intakes are high.

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“…Diet may change the bacterial population and then affect equol production 20. Asian soy‐rich dietary habits are considered to work in favor of equol production.…”

Section: Discussionmentioning

confidence: 99%

“…The rate of equol producers is higher in vegetarians18 and Asian populations and is considered to be associated with the amount of soy intake 19. Equol is more bioavailable than other soy isoflavones, and equol producers are believed to benefit more from soy isoflavones 20. It is plausible that isoflavones may stabilize hormonal fluctuations of the estrogen cycle through their SERM‐like properties and then alleviate premenstrual symptoms 21.…”

Section: Introductionmentioning

confidence: 99%

Premenstrual symptoms interference and equol production status in Japanese collegiate athletes: A cross‐sectional study

Takeda

Ueno

Uchiyama

et al. 2017

J of Obstet and Gynaecol

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AimConsumption of soy isoflavones reduces the risk of estrogen‐related diseases, such as menopausal symptoms, osteoporosis, and cardiovascular disease. Equol is metabolized from the isoflavone daidzein by intestinal bacteria and has higher bioavailability than other isoflavones. Equol producers are believed to benefit from soybean consumption to a greater extent than non‐producers. Recently, we showed that equol non‐producers were at significant risk of premenstrual syndrome (PMS). Previously, we reported that PMS is a common menstrual problem in female athletes, and almost half of the studied athletes felt a negative effect of premenstrual symptoms on their athletic performance. This study was conducted to evaluate the relation between PMS and equol production status in Japanese collegiate athletes.MethodsThis was a cross‐sectional, observational study that included 88 Japanese female collegiate athletes. Equol production status was determined using urine samples collected after a soy challenge test. The subjects also completed a questionnaire about their premenstrual symptoms and their competitive career.ResultsThe prevalence of equol producers was 29.5% in Japanese collegiate athletes. The athletic performance of 54.5% of athletes was found to suffer in competition or in practice due to premenstrual symptoms. In multivariate analysis, equol non‐producers (odds ratio, 3.34; 95% confidence interval, 1.03–12.20) and restriction of bodyweight (odds ratio, 4.94; 95% confidence interval, 1.47–20.00) were shown to be significant risk factors for poor athletic performance.ConclusionThis study showed a relation between athletic performance and equol production status in Japanese collegiate athletes.

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Does equol production determine soy endocrine effects?

Cited by 51 publications

References 133 publications

Expressomal approach for comprehensive analysis and visualization of ligand sensitivities of xenoestrogen responsive genes

Expressomal approach for comprehensive analysis and visualization of ligand sensitivities of xenoestrogen responsive genes

Circulating isoflavone and lignan concentrations and prostate cancer risk: a meta‐analysis of individual participant data from seven prospective studies including 2,828 cases and 5,593 controls

Premenstrual symptoms interference and equol production status in Japanese collegiate athletes: A cross‐sectional study

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