Does esomeprazole prevent post‐operative nausea and vomiting?

Ræder, Johan; Dahl, Vegard; Bjoernestad, E.; Edlund, Gwen M.; Modin, Stefan; Nauclér, Emma; Bergheim, R.; Kilhamn, Jan

doi:10.1111/j.1399-6576.2006.01179.x

Cited by 12 publications

(9 citation statements)

References 24 publications

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“…In a recent study by Raeder et al, the proportion of patients who vomited during the first 24 h after surgery was lower with esomeprazole than with placebo (38% vs. 49%; not significant), and the mean amount of vomit was significantly lower (52 vs. 86 g; P < 0.05). 35 These findings lend weight to the use of esomeprazole in patients with an increased risk of pulmonary aspiration. In conclusion, this trial showed that esomeprazole administered as a single i.v.…”

Section: Discussionmentioning

confidence: 94%

A single dose of intravenous esomeprazole decreases gastric secretion in healthy volunteers

Nichita¹,

Abdou²,

Maerten³

et al. 2009

Aliment Pharmacol Ther

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Section: Discussionmentioning

confidence: 94%

A single dose of intravenous esomeprazole decreases gastric secretion in healthy volunteers

Nichita¹,

Abdou²,

Maerten³

et al. 2009

Aliment Pharmacol Ther

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“…Some studies have reported that PONV is associated with both taking a PPI and GERD. Evidence from randomized trials demonstrated that while taking a PPI preoperatively is not associated with the occurrence of PONV [12,13], GERD is a predictor of PONV [14]. Raeder and colleagues reported that esomeprazole was not effective for PONV but could reduce the amount of vomiting [12].…”

Section: Discussionmentioning

confidence: 99%

“…Evidence from randomized trials demonstrated that while taking a PPI preoperatively is not associated with the occurrence of PONV [12,13], GERD is a predictor of PONV [14]. Raeder and colleagues reported that esomeprazole was not effective for PONV but could reduce the amount of vomiting [12]. Although their study had included relatively large covariates, it may be difficult to generalize the results because of the high proportion (97%) of women.…”

Section: Discussionmentioning

confidence: 99%

Effect of a Preoperative Proton Pump Inhibitor and Gastroesophageal Reflux Disease on Postoperative Nausea and Vomiting

Kwon

Choi

Lee

et al. 2020

JCM

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Postoperative nausea and vomiting (PONV) are common complications after anesthesia, but no study has considered the effects of a proton pump inhibitor (PPI) and gastroesophageal reflux disease (GERD) on PONV at the same time. Thus, we investigated the effects of a PPI and GERD on PONV. Patients aged ≥18 years who underwent general anesthesia between 2010 and 2019 were enrolled. In total, 202,439 patients were included and 21,361 In a multivariate analysis, the OR for PONV was higher in subjects with GERD (OR, 1.157; 95% CI, 1.032-1.298; p = 0.012). The OR was lower for subjects with taking a PPI (OR, 0.890; 95% CI, 0.832-0.953; p < 0.0001). In patients without GERD, the incidence of PONV was lower when lansoprazole (OR, 0.801; 95% CI, 0.718-0.894; p < 0.0001), pantoprazole (OR, 0.856; 95% CI, 0.748-0.980; p = 0.025) and ilaprazole (OR, 0.391; 95% CI, 0.158-0.966; p = 0.042) were taken. However, in GERD patients, all PPIs did not show reducing the incidence of PONV. Taken together, the results show that a lansoprazole, pantoprazole, and ilaprazole reduced PONV in patients without GERD, and PPI could not reduce PONV in patients with GERD.

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“…Esomeprazole (AstraZeneca) [38] Drug Discov Today Ther Strateg. Author manuscript; available in PMC 2008 December 9.…”

Section: Box 1 Conditions With Significant Nausea and Vomitingmentioning

confidence: 99%

Is there a need to identify new anti-emetic drugs?

Horn

2007

Drug Discovery Today: Therapeutic Strategies

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Nausea and vomiting occur in a large number of disease conditions and as side effects of many drug treatments, including use of analgesics and anesthesia in surgery and chemotherapy in cancer treatment. Current anti-emetics provide relief from only some sources of vomiting, with more limited benefits for the control of nausea. Elucidation of forebrain pathways that generate nausea and brainstem circuitry controlling emesis are significant obstacles for the development of effective universal anti-nausea and anti-emetic treatments.

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Does esomeprazole prevent post‐operative nausea and vomiting?

Abstract: Esomeprazole had no clinically relevant effect on the overall 24-h incidence of PONV. However, esomeprazole significantly reduced the total amount of vomit during 24-h post-operatively. This may be of value in patients with an increased risk of pulmonary aspiration.

Cited by 12 publications

References 24 publications

A single dose of intravenous esomeprazole decreases gastric secretion in healthy volunteers

A single dose of intravenous esomeprazole decreases gastric secretion in healthy volunteers

Effect of a Preoperative Proton Pump Inhibitor and Gastroesophageal Reflux Disease on Postoperative Nausea and Vomiting

Is there a need to identify new anti-emetic drugs?

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