Does estrogen directly modulate anti-müllerian hormone secretion in women?

Liberty, Gad; Ben-Chetrit, Avraham; Margalioth, Ehud J.; Hyman, Jordana; Galoyan, Narine; Eldar‐Geva, Talia

doi:10.1016/j.fertnstert.2010.01.018

Cited by 18 publications

(11 citation statements)

References 24 publications

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“…Estradiol, T, and their biological fractions generally increased with increasing AMH level, but tests for trend were not statistically significant. Regarding E 2 , this is consistent with most studies (8, 22, 25–28). Antimüllerian hormone concentration was previously reported to be positively associated with T in healthy women (29), but results are not consistent across studies (28).…”

supporting

confidence: 92%

Serum antimüllerian hormone in healthy premenopausal women

Shaw

Stanczyk

Egleston

et al. 2011

Fertility and Sterility

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Antimüllerian hormone (AMH) is extensively studied in ovarian aging and pathology; however, little is known about correlates in healthy premenopausal women. We found that AMH levels are strongly inversely associated with age and differed significantly between oral contraceptive pill users and nonusers, whereas no significant associations were seen between AMH and other clinical, behavioral, and anthropometric characteristics and laboratory variables, making it an attractive hormone for clinical applications.

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supporting

confidence: 92%

Serum antimüllerian hormone in healthy premenopausal women

Shaw

Stanczyk

Egleston

et al. 2011

Fertility and Sterility

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“…Several reports suggest that AMH might be a better predictor of ovarian responses to controlled ovarian hyperstimulation (COS) than traditional parameters such as age, FSH, estradiol (E 2 ) and inhibin B (INH-B) [7]. This is because AMH levels remain relatively constant throughout the menstrual cycle, and tend to be unaffected by GnRH-agonist pituitary down-regulation or pregnancy ( [15,17]. A previous study has showed that the performance of AMH as a predictor of poor ovarian response was very similar to that achieved with antral follicle counts (AFC) [3].…”

Section: Introductionmentioning

confidence: 99%

The predictive value of anti-mullerian hormone on embryo quality, blastocyst development, and pregnancy rate following in vitro fertilization-embryo transfer (IVF-ET)

Lin

Yao

Zhang

et al. 2013

J Assist Reprod Genet

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Purpose The objective of this study was to investigate the predictive value of anti-Mullerian hormone (AMH) on fertilization rate (FR), blastocyst development, embryo quality, the outcome of the pregnancy and the live birth rate (LBR) following in vitro fertilization-embryo transfer (IVF-ET) /intracytoplasmic sperm injection (ICSI). Method In this prospective study outcomes were followed in 83 women undergoing cycles of IVF/ICSI within a university hospital. Basal serum AMH, follicle stimulating hormone (FSH), luteinizing hormone (LH) and antral follicle count (AFC) were measured on Day 3. Serum AMH (Gn6 AMH ) level was measured on Day 6 after the administration of gonadotrophin (Gn). AMH was measured in follicle fluid (FF AMH) on the day of ovum pick-up (dOPU). The numbers of retrieved and fertilized oocytes, good quality embryos and blastocysts were counted. Secondary outcome variables included clinical pregnancy rate (CPR) and LBR. Results Spearman correlation analysis indicated that the numbers of oocytes, good quality embryos and blastocysts were associated with AMH (P<0.05) and that LBR was correlated with FF AMH (r=0.495, P<0.05). No associations were found between FR and AMH (P>0.05). Receiver operating characteristic analysis showed that the sensitivity of FF AMH at predicting CPR was 91.2 %; the specificity was 86.5 % and ROC AUC was 0.893 (P<0.0001). Conclusion AMH parameters were correlated with good quality embryos and blastocysts, but only FF AMH showed a significant correlation with LBR and CPR.

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“…Increased E2 has been shown to reduce the activation of AMH promoter in some in vitro studies (33,34,35). In contrast there are also studies supporting the opposite or showing that E2 has no direct effect on AMH (36,37,38). Thus, the relationship between AMH and E2 concentrations is still controversial.…”

Section: Discussionmentioning

confidence: 99%

Effects of 5-Hydroxymethylfurfural on Pubertal Development of Female Wistar Rats

Elmaoğulları

Kadan

Anadol

et al. 2020

Jcrpe

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Objective: 5-Hydroxymethylfurfural (HMF) is formed when sugars are heated in the presence of amino acids. HMF is naturally present in many foods. To investigate the toxic effects of HMF on the reproductive system of peripubertal rats. Methods: In the study, 24 immature female Wistar rat were divided into three groups: control (CT) fed with no HMF; low dose fed with 750 mg/kg/day of HMF and high dose (HD) groups fed with 1500 mg/kg/day of HMF. All groups received these diets for three weeks from postnatal day (PND) 21. The vaginal opening (VO) was monitored daily and euthanasia occurred on PND 44. Gonadotropin, estradiol (E2), progesterone and anti-Müllerian hormone (AMH) concentrations were measured. Reproductive organ weights and ovarian follicle counts were compared. Results: The HD HMF group had earlier VO. Higher mean luteinising hormone (2.9±1.2 vs 1.3±0.3 mIU/mL) and mean E2 (34.7±8.8 vs 21.2±3.9 pg/mL) and lower mean AMH (2.7±0.5 vs 4.7±0.7 ng/mL) concentrations were found in the HD compared to the CT group. The HD group also had increased number of secondary atrophic follicles. Conclusion: These results indicate that peripubertal exposure to HMF at HD result in precocious puberty and decreased AMH levels in female Wistar rats. Abstract 79 J Clin Res Pediatr Endocrinol 2020;12(1): [79][80][81][82][83][84][85] What is already known on this topic? What this study adds?5-Hydroxymethylfurfural (HMF) is an organic compound that is present at high amounts in processed foods and foodstuffs as a result of heating, roasting, frying and toasting. Data on potential genotoxic, mutagenic, carcinogenic, DNA-damaging, organotoxic and enzyme inhibitory effects of HMF and its metabolites are conflicting. To the best of our knowledge there are no published data about the effects of HMF on pubertal development. This is the first study of the effects of HMF on pubertal development. The results indicate that peripubertal exposure to HMF in high doses result in precocious puberty and decreased anti-Müllerian hormone levels in female Wistar rats.

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Does estrogen directly modulate anti-müllerian hormone secretion in women?

Cited by 18 publications

References 24 publications

Serum antimüllerian hormone in healthy premenopausal women

Serum antimüllerian hormone in healthy premenopausal women

The predictive value of anti-mullerian hormone on embryo quality, blastocyst development, and pregnancy rate following in vitro fertilization-embryo transfer (IVF-ET)

Effects of 5-Hydroxymethylfurfural on Pubertal Development of Female Wistar Rats

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