Does Estrogen Have Any Real Effect on Voiding Dysfunction in Women?

Koski, Michelle; Chermansky, Christopher

doi:10.1007/s11934-011-0208-y

Cited by 7 publications

(3 citation statements)

References 32 publications

(25 reference statements)

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“…There has been conflicting evidence for the use of oral estrogen therapy to improve symptoms of OAB, as much of the data comes from observational studies. 38 Cardozo et al 39 found both subjective and urodynamic improvement in OAB symptoms in women taking estrogen compared with placebo; however, this was not statistically significant. Benness et al 40 found a statistically significant improvement in urgency in women taking vaginal estrogen compared with placebo.…”

Section: Detrusor Overactivitymentioning

confidence: 96%

The management of lower urogenital changes in the menopause

Singh

Herwijnen

Phillips

2013

Menopause International

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Currently, 25% of women seek the advice of a medical professional for symptoms related to the menopause. However, with an increasingly ageing and medically aware population, it is likely this proportion will grow. The main symptoms related to the menopause are systemic vasomotor and localized urogenital symptoms. Numerous forms of estrogen have been used to alleviate these symptoms. Further problems that increase during the menopause include incontinence, pelvic organ prolapse and recurrent urinary tract infections. This article reviews the process by which estrogen affects the tissues of the urogenital tract, what symptoms occur during this period and what modalities of treatments are available.

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Section: Detrusor Overactivitymentioning

confidence: 96%

The management of lower urogenital changes in the menopause

Singh

Herwijnen

Phillips

2013

Menopause International

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“…The predominant estrogen in human circulation is 17β-estradiol, a potent hormone known to regulate urinary bladder function [ 3 , 4 , 6 , 7 ]. 17β-Estradiol-induced UBSM relaxation has long been established in vitro [ 8 – 10 ] and in vivo [ 11 ].…”

Section: Introductionmentioning

confidence: 99%

Regulation of Guinea Pig Detrusor Smooth Muscle Excitability by 17β-Estradiol: The Role of the Large Conductance Voltage- and Ca2+-Activated K+ Channels

et al. 2015

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Estrogen replacement therapies have been suggested to be beneficial in alleviating symptoms of overactive bladder. However, the precise regulatory mechanisms of estrogen in urinary bladder smooth muscle (UBSM) at the cellular level remain unknown. Large conductance voltage- and Ca2+-activated K+ (BK) channels, which are key regulators of UBSM function, are suggested to be non-genomic targets of estrogens. This study provides an electrophysiological investigation into the role of UBSM BK channels as direct targets for 17β-estradiol, the principle estrogen in human circulation. Single BK channel recordings on inside-out excised membrane patches and perforated whole cell patch-clamp were applied in combination with the BK channel selective inhibitor paxilline to elucidate the mechanism of regulation of BK channel activity by 17β-estradiol in freshly-isolated guinea pig UBSM cells. 17β-Estradiol (100 nM) significantly increased the amplitude of depolarization-induced whole cell steady-state BK currents and the frequency of spontaneous transient BK currents in freshly-isolated UBSM cells. The increase in whole cell BK currents by 17β-estradiol was eliminated upon blocking BK channels with paxilline. 17β-Estradiol (100 nM) significantly increased (~3-fold) the single BK channel open probability, indicating direct 17β-estradiol-BK channel interactions. 17β-Estradiol (100 nM) caused a significant hyperpolarization of the membrane potential of UBSM cells, and this hyperpolarization was reversed by blocking the BK channels with paxilline. 17β-Estradiol (100 nM) had no effects on L-type voltage-gated Ca2+ channel currents recorded under perforated patch-clamp conditions. This study reveals a new regulatory mechanism in the urinary bladder whereby BK channels are directly activated by 17β-estradiol to reduce UBSM cell excitability.

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“…Randomised-controlled trials confirm that oestrogen use in post-menopausal women decreases the rate recurrent urinary tract infections and urinary incontinence. 77 …”

Section: Urinary Tract Infection and Incontinencementioning

confidence: 99%

The clinical consequences of an ageing world and preventive strategies

Lunenfeld¹,

Stratton²

2013

Best Practice & Research Clinical Obstetrics & Gynaecol

222

128

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Over the past century, the world has seen unprecedented declines in mortality rates, leading to an accelerated increase in the world population. This century will realise falling fertility rates alongside ageing populations. The 20th century was the century of population growth; the 21st century will be remembered as the century of ageing. Increase in life expectancy is one of the highest achievements of humankind; however, ageing and age-related disease is a mounting challenge for individuals, families, and for social, economic, and healthcare systems. Since healthy life expectancy has lagged behind the increase in life expectancy, the rise in morbidity will increase the burden on healthcare systems. Implementation of preventive health strategies to decrease, delay or prevent frailty, lung, breast and colon cancer, cardiovascular disease, metabolic syndrome, osteoporosis and osteopaenia, may increase health expectancy, and permit women to age gracefully and maintain independent living, without disability, for as long as possible.

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Does Estrogen Have Any Real Effect on Voiding Dysfunction in Women?

Cited by 7 publications

References 32 publications

The management of lower urogenital changes in the menopause

The management of lower urogenital changes in the menopause

Regulation of Guinea Pig Detrusor Smooth Muscle Excitability by 17β-Estradiol: The Role of the Large Conductance Voltage- and Ca2+-Activated K+ Channels

The clinical consequences of an ageing world and preventive strategies

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