Does ethyl glucuronide in hair correlate with alcohol consumption? A comparative study with other traditional biomarkers among individuals with alcohol dependence syndrome

Ghosh, Shayani; Jain, Raka; Rao, Ravindra; Mishra, Ashwani Kumar; Jhanjee, Sonali

doi:10.1016/j.alcohol.2022.10.005

Cited by 3 publications

(1 citation statement)

References 34 publications

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“…The research during this period aimed to understand the association between laboratory biomarkers and alcohol dependence severity. Specifically, the focus was on cortisol,[ 189 190 ] brain-derived neurotrophic factor,[ 191 ] carbohydrate-deficient transferrin,[ 27 ] ethyl glucuronide (ETG),[ 192 ] ethyl sulfate (ETS), and liver function tests [ Table 3 ]. [ 193 194 195 196 197 198 ] Electroencephalogram correlates of alcohol dependence were also the areas of interest.…”

Section: Laboratory-related Researchmentioning

confidence: 99%

Alcohol use disorder research in India: An update

Narasimha,

Mukherjee,

Arya

et al. 2024

Indian Journal of Psychiatry

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Background: Despite alcohol use being a risk factor for numerous health-related conditions and alcohol use disorder (AUD) recognized as a disease, there was limited research in India until 2010. This narrative review aims to evaluate AUD-related research in India from 2010 to July 2023. Methods: A PubMed search used key terms for AUD in India after 2010. Indian and international journals with regional significance that publish alcohol-related research were searched by each author individually. These were then collated, and duplicates were removed. In addition, we also conducted a gray literature search on focused areas related to AUD. Results: The alcohol-related research in India after 2010 focused on diverse areas associated with alcohol use. Some areas of research have received more attention than others. Two major epidemiological surveys conducted in the past decade reveal that around 5% have a problematic alcohol use pattern. Factors associated with alcohol use, like genetic, neurobiological, psychological, and sociocultural, were studied. The studies focused on the clinical profile of AUD, including their correlates, such as craving, withdrawal, alcohol-related harm, and comorbid psychiatric and medical illnesses. During this period, minimal research was conducted to understand AUD’s laboratory biomarkers, course, and prognosis. While there was a focus on generating evidence for different psychological interventions for alcohol dependence in management-related research, pharmacological studies centered on anticraving agents like baclofen. Research on noninvasive brain stimulation, such as rTMS, has shown preliminary usefulness in treating alcohol dependence. Very little research has been conducted regarding alcohol policy. Conclusion: In the past decade, Indian research on alcohol has focused on diverse areas. Epidemiological and psychological management-related research received maximum attention. Considering the magnitude of the alcohol-related burden, it is essential to prioritize research to other less studied areas like pharmacological management of alcohol dependence and alcohol policy.

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Section: Laboratory-related Researchmentioning

confidence: 99%

Alcohol use disorder research in India: An update

Narasimha,

Mukherjee,

Arya

et al. 2024

Indian Journal of Psychiatry

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Response to the critical comments on the article “Driving license regranting: Hair EtG, serum CDT, and the role of sociodemographic and medicolegal variables”

Cinquetti,

Terranova,

Aprile

et al. 2023

Drug Testing and Analysis

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Rapid and Effective Determination of Ethyl Glucuronide in Hair by Micro Extraction by Packed Sorbent (MEPS) and LC‐MS/MS

Odoardi,

Mestria,

Valentini

et al. 2024

Drug Testing and Analysis

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Ethyl glucuronide (EtG) in hair is a reliable biomarker of alcohol consumption habits. Due to its small concentration incorporated into hair, analytical methods sensitive enough to reliably quantify EtG in this matrix are required. Sample preparation is critical in hair analysis, especially for EtG, for which extraction efficiency and matrix effect can strongly influence the results; furthermore, miniaturized methods are sought, to reduce solvent use and times of sample preparation. A micro extraction by packed sorbent (MEPS) procedure coupled to a high‐performance liquid chromatography–tandem mass spectrometry method was developed and validated for quantitation of EtG in human hair samples. Fifty milligrams of hair samples were cut into snippets and extracted in water. The cleanup of the extract was carried out by using a MEPS syringe packed with anion exchange sorbent (SAX); all parameters for conditioning, washing, loading and eluting steps were optimized and the eluted aqueous volume was directly injected in the LC–MS/MS system operating in the negative ionization mode. The method was fully validated assessing LOD, LOQ, calibration curve, repeatability, accuracy, matrix effect and carryover. The method was subsequently applied to QCs and authentic hair samples. The developed MEPS method is quick and effective, with low solvent purchase and discard costs, allowing the differentiation between social drinkers and chronic excessive alcohol consumers, according to the cut‐offs established by the Society of Hair Testing (SoHT).

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Does ethyl glucuronide in hair correlate with alcohol consumption? A comparative study with other traditional biomarkers among individuals with alcohol dependence syndrome

Cited by 3 publications

References 34 publications

Alcohol use disorder research in India: An update

Alcohol use disorder research in India: An update

Response to the critical comments on the article “Driving license regranting: Hair EtG, serum CDT, and the role of sociodemographic and medicolegal variables”

Rapid and Effective Determination of Ethyl Glucuronide in Hair by Micro Extraction by Packed Sorbent (MEPS) and LC‐MS/MS

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