Does gastric bypass alter alcohol metabolism?

Psychiatric Disorders and weight Change in a Prospective Study of Bariatric Surgery Patients: A 3-Year Follow-Up

“…Methods and baseline data on psychiatric disorders have been reported previously (5). Of note, the SCID screener for alcohol use disorder required reporting having drunk five or more drinks on one occasion, a threshold that might be too high after bariatric surgery given evidence that alcohol pharmacokinetics may be altered by some procedures, thereby decreasing tolerance (20)(21)(22)(23). Lifetime history was assessed at the pre-surgery assessment.…”

Cambio en el patrón de consumo de sustancias posterior a cirugía bariátrica: presentación de un caso clínico

“…Estudios realizados en Chile, en pacientes sometidos a gastrectomía vertical ("manga gástrica") han sido coincidentes en demostrar que los cambios anató-micos digestivos modifican considerablemente la absorción de alcohol alcanzando niveles plasmá-ticos más altos y persistentes 14 . Se ha relacionado el rápido vaciamiento gástrico al aumento en la velocidad de absorción y la reducción del volumen del estómago a menor cantidad de alcohol deshidrogenasa, afectando el metabolismo de la sustancia 15 . Por su parte, la marcada disminución del IMC podría ser un factor a considerar si las cantidades de consumo previo se mantienen 16 .…”

Addictive Disorders in Nutritional Diseases ‐ From a Nutritional Viewpoint

“…Since those individuals who qualify for surgery (those with BMI of 40 or greater) also have problems controlling food intake, the reduction in stomach capacity can present a major obstacle to successful weight loss if the individual has not learned to adjust food intake prior to surgery. Bariatric surgery reduces mortality rates due to diabetes, cardiovascular disease, hypertension, and stroke [39] in severely obese individuals. Although the benefits of bariatric surgery are impressive with respect to reductions in mortality, a new "concern" with respect to substance addiction in post-bariatric surgery patients has developed, specifically alcohol addiction.…”

“…The increase in alcohol consumption also has an effect on weight loss and maintenance after bariatric surgery, as alcohol contributes calories as well as modulation of the reward circuitry [39]. Alcohol consumption also causes a shift in macronutrient preference, as those who consume more alcohol after bariatric surgery also tend to increase intake of lipids and proteins, and decrease intake of carbohydrates [39].…”

“…Alcohol consumption also causes a shift in macronutrient preference, as those who consume more alcohol after bariatric surgery also tend to increase intake of lipids and proteins, and decrease intake of carbohydrates [39]. In addition, alcohol metabolism is altered in bariatric patients with intoxication occurring at lower levels of alcohol intake than before surgery [40,43].…”