Does gender influence the outcomes of total ankle arthroplasty in patients with ankle osteoarthritis?

Abstract

Background: Total ankle arthroplasty has progressed as a treatment option for patients with ankle osteoarthritis. However, no studies have been conducted to evaluate the effect of gender on the outcome. The purpose of the present study was to evaluate outcomes, survivorship, and complications rates of total ankle arthroplasty, according to gender differences. Methods: This study included 187 patients (195 ankles) that underwent mobile-bearing HINTEGRA prosthesis at a mean follow-up of 7.5 years (range, 4 to 14). The two groups consisted of a men's group (106 patients, 109 ankles) and a women's group (81 patients, 86 ankles). Average age was 64.4 years (range, 45 to 83). Results: Clinical scores on the Ankle Osteoarthritis Scale for pain and disability, and American Orthopaedic Foot and Ankle Society ankle-hindfoot score improved and the difference was not statistically significant between the two groups at the final follow-up. There were no significant differences in complication rates and implant survivorship between the two groups. The overall survival rate was 96.4% in men and 93.4% in women at a mean follow-up of 7.5 years (p = 0.621). Conclusions: Clinical outcomes, complication rates, and survivorship of total ankle arthroplasty were comparable between men and women. These results suggest that gender did not seem to affect outcomes of total ankle arthroplasty in patients with ankle osteoarthritis.

Effect of Gender Differences on Patient-Reported Outcomes and Complications in Total Ankle Replacement

“…Lee et al reported that women showed higher prevalence of TAR osteolysis and its associated complications compared with men, but this was not statistically significant. 21 Similarly, we found no significant differences in failure rates and implant survivorship between the 2 groups. 21…”

“…21 Similarly, we found no significant differences in failure rates and implant survivorship between the 2 groups. 21…”

“…In the only previous study assessing the influence of gender on outcomes following TAR, Lee et al 21 included 187 patients with primary osteoarthritis that underwent mobilebearing HINTEGRA prosthesis. Their PROs collected included the Ankle Osteoarthritis Scale (AOS) pain and disability, AOFAS, SF-36, and VAS.…”

“…There has only been 1 previous study examining gender differences on outcomes following TAR. 21 This study included 187 patients with primary osteoarthritis and a single implant design, HINTEGRA. Lee et al found comparable clinical outcomes, complication rates, and survivorship of TAR between men and women.…”

“…Lee et al found comparable clinical outcomes, complication rates, and survivorship of TAR between men and women. 21 The objective of this study was to determine the effect of gender on PROs, complication rates, and implant survivorship following TAR. Based on the current body of literature, we hypothesized that men would have better PROs following TAR.…”