Does glucagon like peptide-2 receptor expression have any effect on the development of human colorectal cancer?

Abstract

Amaç: ‹nsanlarda kolon kanseri ve bunun öncüsü kolon poliplerinin oluflumu ile glukagon like peptid-2 (GLP-2) ve glukagon like peptid-2 reseptör aras›ndaki iliflkiyi göstererek kolon polip ve kanseri geliflim patogenezine katk›da bulunmakt›r.Yöntem: Alt gastrointestinal sistem endoskopisi esnas›nda kolon polibi saptan›p biyopsi al›nan ve yine endoskopik ifllemde kolon kanseri ile uyumlu bulgular› saptan›p biyopsi al›nan hastalardan, patolojik tan›lar› kolon polibi ve kolon kanseri olan, kolon polibi grubuna 20 hasta (12 E, 8 K, ortalama yafl: 64±9.4); kolon kanseri grubuna 30 hasta (17 E, 13 K, ortalama yafl: 62±10,7)

GLP-2 receptors in human disease: High expression in gastrointestinal stromal tumors and Crohn’s disease

“…No autoradiographically measurable GLP-2 receptors could be identified in tumor types previously reported to express these receptors using RT-PCR and immunohistochemistry, such as ileal carcinoid tumors and gastrointestinal adenocarcinomas (Bengi et al, 2011;Koehler et al, 2008Koehler et al, , 2005Masur et al, 2006;Yusta et al, 2000b). The GLP-2 receptor expression in these tumors can therefore be assumed to be rather focal and weak.…”

“…For instance, somatostatin receptors expressed by isolated intraepithelial endocrine cells and small tumor cell clusters are visualized with immunohistochemistry, but not with receptor autoradiography (Körner et al, 2012). As for GLP-2 receptors, this may explain why small groups of normal gastrointestinal cells as well as ''small focal areas'' and ''rare cells'' of tumors previously reported to show GLP-2 receptor immunoreactivity (de Heer et al, 2007;Guan et al, 2006;Ørskov et al, 2005;Bengi et al, 2011;Koehler et al, 2005;Yusta et al, 2000a) and likely to be detected by RT-PCR do not produce a discernable autoradiography signal. It has, though, also to be considered that small numbers of normal gastrointestinal cells with physiological GLP-2 receptor expression that ''contaminate'' carcinoma tissue homogenates may produce a positive RT-PCR result in a tumor sample without GLP-2 receptor expression in tumor cells.…”

Review article: a comparison of glucagon‐like peptides 1 and 2

“…However, there has been no evidence of dysplasia or malignancy reported with the use of GLP‐2 in humans . Indeed, a recent report suggests that human colon cancer has less expression of GLP‐2R protein than the surrounding noncancerous tissue . However, in preclinical models in which a known carcinogen was first used to induce a malignancy, GLP‐2 may promote tumourigenesis .…”

The effect of glucagon‐like peptide‐1 and glucagon‐like peptide‐2 on microcirculation: A systematic review

“…As GLP‐2 suppresses apoptosis and promotes mucosal proliferation, concerns have been raised regarding a carcinogenic effect of GLP‐2, as supported by experimental studies . This may pose a serious problem if GLP‐2 was to be used as an anastomotic protecting therapy after bowel resection.…”