Does HBA1C Correlate with Lipid Profile in Type 2 Diabetes Mellitus? A New Evidence from Medan, North Sumatera

Julianto, Endy; Silitonga, Hendrika Andriana; Siahaan, Jekson Martiar

doi:10.26911/theijmed.2017.02.03.08

Cited by 2 publications

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“…But when STG, LDLC, and HDLC of the patients and the controls were compared respectively, all three of them possessed higher significance (p <.0001) based on HbA1c concentration in both groups with 10-197 mg/dL for STGs (Figure 3D); 46-127 mg/dL for HDLC (Figure 3C) and 23-149 mg/dL for LDLC (Figure 3F). This positive association is similar to a previous study that demonstrated the significant association of TG, LDLC, and HDLC in comparison to HbA1c [61].…”

Section: Analysis Of the Serological Parameterssupporting

confidence: 92%

Serological and Oncoinformatic Analysis of HbA1c as a Prognostic Biomarker in Screening the Risks of Different Cancers among the Male T2D Patients of Bangladesh

Hasibuzzaman¹,

Azad²,

Mia³

et al. 2022

Preprint

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This research aimed to figure out the applications of HbA1c protein and HbA1 gene as the prognostic biomarkers for assessing the risks of different cancers among male T2D patients in Bangladesh considering their serological and oncoinformatic parameters. Depending on the concentrations of HbA1c (%) of the T2D patients (n=300), their individual FBS (mmol/L); THABF (mmol/L); creatinine (mg/dl); SC (mg/dl); STGs (mg/dl); HDLC (mg/dl); and LDLC (mg/dl) were estimated. The values of the patients were compared with the control (n=60) group as the serological analysis. Besides, HbA1 gene (encoding hBA1c protein) overexpression and promotor methylation responsible for BLCA, BRCA, CHOL, COAD, LUAD, LUSC, PAAD, and PRAD cancers in the male T2D patients were profiled as the oncoinformatic parameters based on the sample types; caner stages; racial footprints; gender; age; nodal metastasis; p53 methylations; pancreatitis; diabetes status; smoking behaviors; and overall/disease-free survivability. Finally, the ‘HbA1 gene strings’ responsible for genetic coexpression; endophytic vesicle regulation; antioxidant regulation; oxygen species metabolic regulation; and gene-mediated response to the reactive oxygen molecules were studied comprehensively. A strong correlation between BMI and FBS was observed in both the patients and the control (P<0.0001). Similarly, the values of FBS, THABF, and creatinine resulted in equal significance (P<0.0001) as compared to the HbA1c concentrations of all the T2D and control individuals. The SC, STGs, HDLC, and LDLC concentrations regulated ardently in both the control (P<0.0001), and patients group (P<0.0001), while HbA1c ranged from 3.8-5.8%, and 5.11-15.8% respectively. HbA1 gene is found downregulating with cancer progressed in most of the oncoinformatic parameters. According to the DA, CS, EI, CE, PC, NC, GF, H, and AT profiles; the HbA1 gene interacts with 8 other genes responsible for creating a protein cluster comprising- AHSP, HBA1, HBA2, HBB, HBD, HBE1, HBG2, RPS12, and RPS19 proteins for cancer formation. To recapitulate, HbA1c protein and HbA1 gene can be used as the prognostic serological and molecular biomarkers respectively for determining the risks of cancers among male chronic T2D patients.

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Section: Analysis Of the Serological Parameterssupporting

confidence: 92%

Serological and Oncoinformatic Analysis of HbA1c as a Prognostic Biomarker in Screening the Risks of Different Cancers among the Male T2D Patients of Bangladesh

Hasibuzzaman¹,

Azad²,

Mia³

et al. 2022

Preprint

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“…Menurut Julianto dkk bahwa HbA1c tidak memiliki hubungan terhadap profil lipid. 16 Menurut Sumampouw dan Halim bahwa HbA1c tidak memiliki hubungan terhadap kolesterol total, kolesterol HDL, dan kolesterol LDL. 17 Menurut Rosmee dan Koley bahwa HbA1c tidak memiliki hubungan terhadap kolesterol HDL.…”

Section: Pembahasanunclassified

Profil Lipid Pada Pasien Diabetes Melitus Tipe 2 di RSUP Sanglah Denpasar Tahun 2019

Siorcani,

Suastika,

Gotera

et al. 2022

eum

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Prevalensi dislipidemia dua kali lebih tinggi ditemukan pada diabetes melitus. Studi potong lintang dengan teknik consecutive sampling menggunakan data sekunder seperti data rekam medis dari pasien diabetes melitus tipe 2 di RSU Pusat Sanglah tahun 2019. Dari 138 sampel ditemukan 69.6% laki-laki dan 30.4% perempuan. Prevalensi dislipidemia pada total sampel berturut-turut yaitu hiperkolesterolemia sebesar 42%, peningkatan kolesterol LDL sebesar 75.4%, penurunan kolesterol HDL sebesar 67.4%, dan hipertrigliseridemia sebesar 54.3%. Berdasarkan analisis uji korelasi ditemukan bahwa glukosa darah puasa memiliki hubungan yang sangat lemah terhadap trigliserida (r=0.177, p=0.045), sedangkan glukosa darah puasa tidak signifikan memiliki hubungan terhadap kolesterol total, kolesterol HDL, dan kolesterol LDL (r=0.167, p=0.058; r=0.101, p=0.253; r=0.042, p=0.636). Selain itu HbA1c tidak signifikan memiliki hubungan terhadap profil lipid (r=0.050, p=0.585; r=0.080, p=0.385; r=0.048, p=0.601; r=-0.068, p=0.463). Simpulan pada penelitian ini bahwa glukosa darah puasa memiliki hubungan terhadap trigliserida, namun glukosa darah puasa tidak memiliki hubungan terhadap kolesterol total, kolesterol HDL, dan kolesterol LDL. Sementara HbA1c tidak memiliki hubungan terhadap profil lipid dari pasien diabetes melitus tipe 2 di RSU Pusat Sanglah tahun 2019. Kata kunci: Profil Lipid, Glukosa Darah Puasa, HbA1c

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Does HBA1C Correlate with Lipid Profile in Type 2 Diabetes Mellitus? A New Evidence from Medan, North Sumatera

Cited by 2 publications

References 0 publications

Serological and Oncoinformatic Analysis of HbA1c as a Prognostic Biomarker in Screening the Risks of Different Cancers among the Male T2D Patients of Bangladesh

Serological and Oncoinformatic Analysis of HbA1c as a Prognostic Biomarker in Screening the Risks of Different Cancers among the Male T2D Patients of Bangladesh

Profil Lipid Pada Pasien Diabetes Melitus Tipe 2 di RSUP Sanglah Denpasar Tahun 2019

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