Does Helicobacter pylori protect against asthma and allergy?

Blaser, Martin J.; Chen, Yu; Reibman, Joan

doi:10.1136/gut.2007.133462

Cited by 207 publications

(167 citation statements)

References 71 publications

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“…Eradication of Helicobacter pylori, the strongest risk factor for gastric non-cardia adenocarcinoma, may reduce its incidence (Talley, 2008). However, recent studies suggest that H. pylori may have health benefits, such as preventing asthma (Blaser et al, 2008) or oesophageal adenocarcinoma (Islami and Kamangar, 2008). Beyond the direct benefits and risks of eradication to the individual, the methods and consequences of attempted widespread eradication, such as increasing antibiotic resistance, must also be considered (Graham and Shiotani, 2008).…”

Section: Discussionmentioning

confidence: 99%

Non-steroidal anti-inflammatory drugs and risk of gastric and oesophageal adenocarcinomas: results from a cohort study and a meta-analysis

et al. 2009

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Use of aspirin or other non-steroidal anti-inflammatory drugs (NSAIDs) may reduce the risk of gastric or oesophageal adenocarcinomas. We examined the association between self-reported use of aspirin or non-aspirin NSAIDs in the earlier 12 months and gastric non-cardia (N ¼ 182), gastric cardia (N ¼ 178), and oesophageal adenocarcinomas (N ¼ 228) in a prospective cohort (N ¼ 311 115) followed for 7 years. Hazard ratios (HRs) and 95% confidence intervals (CIs) come from Cox models adjusted for potential confounders. Use of any aspirin (HR, 95% CI: 0.64, 0.47 -0.86) or other NSAIDs (0.68, 0.51 -0.92) was associated with a significantly lower risk of gastric non-cardia adenocarcinoma. Neither aspirin (0.86, 0.61 -1.20) nor other NSAIDs (0.91, 0.67 -1.22) had a significant association with gastric cardia cancer. We found no significant association between using aspirin (1.00, 0.73 -1.37) or other NSAIDs (0.90, 69 -1.17) and oesophageal adenocarcinoma. We also performed a meta-analysis of the association between the use of NSAIDs and risk of gastric and oesophageal adenocarcinoma. In this analysis, aspirin use was inversely associated with both gastric and oesophageal adenocarcinomas, with summary odds ratios (95% CI) for non-cardia, cardia, and oesophageal adenocarcinomas of 0.

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Section: Discussionmentioning

confidence: 99%

Non-steroidal anti-inflammatory drugs and risk of gastric and oesophageal adenocarcinomas: results from a cohort study and a meta-analysis

et al. 2009

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“…Its recent disappearance in the developed world has been accompanied by changes in gastric acid physiology, peptide secretion, regulatory T cell populations, and even the production of the satiety peptide ghrelin [50]. Is it possible that the decline in H. pylori prevalence is somehow linked with the rise in obesity and the prevalence of gastric GCA?…”

Section: Dietmentioning

confidence: 99%

Obesity and related risk factors in gastric cardia adenocarcinoma

Olefson

Moss

2014

Gastric Cancer

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Over recent decades, the incidence of cancers of the gastroesophageal junction, including gastric cardia tumors, has increased markedly. This is a trend that has been well documented, especially in studies from the USA and northern Europe that have also demonstrated a concomitant rise in the ratio of cardia to distal gastric cancers. The rise in the prevalence of gastric cardia adenocarcinoma has been paralleled by the worldwide obesity epidemic, with almost all epidemiological studies reporting increased body mass index and obesity increase the risk of cardia cancer development. However, the strength of this association is less marked than the link between obesity and esophageal adenocarcinoma, and the mechanisms remain poorly understood. Other possible confounders of the relationship between obesity and cardia cancer include the decline in Helicobacter pylori infection and the widespread use of proton pump inhibitors, although these have rarely been controlled for in case-control and cohort studies investigating associations between obesity and cardia cancer. We review these epidemiological trends and discuss proposed mechanisms for the association, drawing attention to controversies over the difficulty of defining cardia cancer. The relative paucity of high-quality epidemiological studies from other regions of the world should prompt further investigation of this issue, especially in populations undergoing rapid socioeconomic change.

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“…13 However, this study suggested that certain types of allergies may be associated with reduced risk of gastric cancer.…”

Section: 조수정 아토피 피부염이 위암 발생을 줄이는가?mentioning

confidence: 89%

Does Atopic Dermatitis Reduce the Incidence of Gastric Cancer?

Cho

2018

Korean J Gastroenterol

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Article: Associations between Atopic Dermatitis and Risk of Gastric Cancer: A Nationwide Population-based Study (Korean J Gastroenterol 2018;71:38-44) CC This is an open access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/ by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Does Helicobacter pylori protect against asthma and allergy?

Cited by 207 publications

References 71 publications

Non-steroidal anti-inflammatory drugs and risk of gastric and oesophageal adenocarcinomas: results from a cohort study and a meta-analysis

Non-steroidal anti-inflammatory drugs and risk of gastric and oesophageal adenocarcinomas: results from a cohort study and a meta-analysis

Obesity and related risk factors in gastric cardia adenocarcinoma

Does Atopic Dermatitis Reduce the Incidence of Gastric Cancer?

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