Does Melatonin Ameliorate Neurological Changes Associated With Alzheimer’s Disease in Ovariectomized Rat Model?

Ahmed, Hanaa H.; Estefan, Selim F.; Mohamd, Ehab M.; Farrag, Abd El-Razik H.; Salah, Rania

doi:10.1007/s12291-012-0284-x

Cited by 13 publications

(7 citation statements)

References 48 publications

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“…It has been reported that decreased expression of BDNF, which maintains normal neuronal circuits in the brain, appears to play an important role in the development of several neurodegenerative diseases. The reduction of BDNF following Al intoxication in the current study was previously reported (2,9,38). In addition, Al impairs various enzymes involved in neurotransmitters biosynthesis and one of its potential toxic mechanisms of action may include disruption in serotonergic neurotransmissions in the brain hippocampus (6,44).…”

Section: • Oh) Involved In the Initiation Of Lipid Peroxidation (14)supporting

confidence: 70%

“…Al disrupts the pro-inflammatory cytokine/neurotrophic balance that plays an important role in neurodegenerative disorders (38). Al intoxication in the current study induced brain apoptosis as demonstrated by increased brain Casp-3 and TNF-α levels.…”

Section: • Oh) Involved In the Initiation Of Lipid Peroxidation (14)mentioning

confidence: 49%

“…The participation of free radical-induced oxidative brain cell injury in aluminium toxicity has been previously proposed (37)(38)(39). Our data demonstrated that sub-chronic aluminium administration to rats significantly reduced the brain total antioxidant status (TAS) with concomitant enhancement of lipid peroxidation (LPO), verifying the oxidative stress-related changes that contribute to Al neurotoxicity.…”

Section: Discussionmentioning

confidence: 99%

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Neuroprotective effects of eugenol against aluminiuminduced toxicity in the rat brain

Said

Rabo

2017

Archives of Industrial Hygiene and Toxicology

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Aluminium (Al) is a neurotoxic metal that contributes to the progression of several neurodegenerative diseases. The aim of the present study was to evaluate the protective effect of dietary eugenol supplementation against aluminium (Al)- induced cerebral damage in rats. Male Wistar rats were divided into four groups: normal controls, rats fed a diet containing 6,000 μg g-1 eugenol, rats intoxicated daily with aluminium chloride (84 mg kg-1 body weight) p. o. and fed either a basal diet or a eugenol-containing diet. Daily oral administration of Al for four consecutive weeks to rats significantly reduced brain total antioxidant status (TAS) (11.42±0.31 μmol g-1 tissue, p<0.001) with a subsequent significant enhancement of lipid peroxidation (MDA) (32.55±1.68 nmol g-1 tissue, p<0.002). In addition, Al enhanced brain acetylcholinesterase activity (AChE) (46.22±4.90 U mg-1 protein, p<0.001), tumour necrosis factor alpha (TNF-α) (118.72±11.32 pg mg-1 protein, p<0.001), and caspase 3 (Casp-3) (8.77±1.26 ng mg-1 protein, p<0.001) levels, and in contrast significantly suppressed brain-derived neurotrophic factor (BDNF) (82.74±14.53 pg mg-1 protein, p<0.002) and serotonin (5-HT) (1.54±0.12 ng mg-1 tissue, p<0.01) levels. Furthermore, decreased glial fibrillary acidic protein (GFAP) immunostaining was noticed in the striatum of Al-intoxicated rats, compared with untreated controls. On the other hand, co-administration of dietary eugenol with Al intoxication restored brain BDNF (108.76±2.64 pg mg-1 protein) and 5-HT (2.13±0.27 ng mg-1 tissue) to normal levels, enhanced brain TAS (13.43±0.24 μmol g-1 tissue, p<0.05), with a concomitant significant reduction in TNF-α (69.98±4.74 pg mg-1 protein) and Casp-3 (3.80±0.37 ng mg-1 protein) levels (p<0.001), as well as AChE activity (24.50±3.25 U mg-1 protein, p<0.001), and increased striatal GFAP immunoreactivity, compared with Al-treated rats. Histological findings of brain tissues verified biochemical data. In conclusion, eugenol holds potential as a neuroprotective agent through its hydrophobic, antioxidant, and anti-apoptotic properties, as well as its neurotrophic ability against Al-induced brain toxicity in rats.

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Section: • Oh) Involved In the Initiation Of Lipid Peroxidation (14)supporting

confidence: 70%

Section: • Oh) Involved In the Initiation Of Lipid Peroxidation (14)mentioning

confidence: 49%

Section: Discussionmentioning

confidence: 99%

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Neuroprotective effects of eugenol against aluminiuminduced toxicity in the rat brain

Said

Rabo

2017

Archives of Industrial Hygiene and Toxicology

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“…Melatonin and its activated receptors have been linked to the regulation of neurotrophic factors, including BDNF. Both Gproteins-mediated signalling and other pathways such as extracellular signal-regulated kinase (ERK) may contribute to melatonin action on BDNF [158]. Further, melatonin exerts beneficial effects on cholinergic neurotransmission in the brain by increasing the activities of choline acetyl transferase (ChAT) enzyme in the frontal cortex and hippocampus [158].…”

Section: Melatonin As Neuromodulatory Moleculementioning

confidence: 99%

“…Both Gproteins-mediated signalling and other pathways such as extracellular signal-regulated kinase (ERK) may contribute to melatonin action on BDNF [158]. Further, melatonin exerts beneficial effects on cholinergic neurotransmission in the brain by increasing the activities of choline acetyl transferase (ChAT) enzyme in the frontal cortex and hippocampus [158]. In addition to this, melatonin directly detoxifies free radicals and thus can enhance brain Ach activity as a result of the presence of an electron rich aromatic indole ring as an electron-donor.…”

Section: Melatonin As Neuromodulatory Moleculementioning

confidence: 99%

An insight into the scientific background and future perspectives for the potential uses of melatonin

Anwar

Muhammad²,

Bader³

et al. 2015

Egyptian Journal of Basic and Applied Sciences

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Antiepileptic Antiosteoporotic Antioxidant Cardiovascular disease Circardian rhythm Hypnotic Immunodulatory Melatonin a b s t r a c t Melatonin is one of the most versatile and ubiquitous molecule widely distributed in nature has been reported to play a role in a wide variety of physiological responses including reproduction, circadian homeostasis, sleep, retinal neuromodulation, and vasomotor responses. In most vertebrates, including humans, melatonin is synthesized primarily in the pineal gland and is regulated by the environmental light ⁄ dark cycle via the suprachiasmatic nucleus. Melatonin is synthesized in all areas of the body such as gastrointestinal tract, skin, bone marrow, retina and in lymphocytes, from which it may influence other physiological functions through paracrine signalling. In addition to regulation of circadian rhythm of melatonin a variety of other physiological effects such as hypnotic, antidepressant, antiepileptic, oncostatic, immunomodulatory, antiosteoporotic, in cardiovascular disease, neuromodulatory and cerebral ischaemic condition have been reported.Moreover there is scarcity of literature that reviewed the scientific evidence for its use in these conditions. Therefore in this article we review recent advances in this research field, which is preceded by a concise account of general information about melatonin, melatonin receptors and intracellular signalling pathways for melatonin actions.

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GC/MS and LC‐ESI‐MS Analysis of Conocarpus erectus Leaves Extract via Regulating Amyloid‐β‐Peptide, Tau Protein, Neurotransmitters, Inflammation and Oxidative Stress against AlCl₃‐Induced Alzheimer's Disease in Rats

Nasr,

El‐Hagrassi,

Ahmed

et al. 2024

Chemistry & Biodiversity

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This study investigated the therapeutic effect of Conocarpus erectus leaves methanolic extract against AlCl3 ‐induced Alzheimer’s disease (AD) in rats comparing with Donepezil‐hydrochloride as a reference drug. The bioactive compounds of C. erectus leaves were isolated and identified by GC/MS and LC‐ESI‐MS analysis. Malondialdehyde (MDA), reduced glutathione (GSH), superoxide dismutase (SOD), tumor necrosis factor‐alpha (TNF‐α), interleukin‐6 (IL‐6), amyloid‐β‐peptide (Aβ‐peptide), tau protein, acetylcholinesterase (AChE), serotonin (5‐HT), dopamine (DA) and nor‐adrenaline (NE) levels were estimated. The neuromuscular strength, memory behavior and histopathological examination of cerebral cortex region were also conducted. Forty‐three compounds were characterized from the non‐polar fraction of C. erectus L. leaves extract and nineteen compounds were identified from the defatted extract. AlCl3‐ induction caused significant elevation of brain oxidative stress, Aβ‐peptide, tau protein, IL‐6, TNF‐α and AChE levels. A significant decrease in 5‐HT, ND and DA levels were noticed. Additionally, AlCl3 reduced neuromuscular strength and compromised memory function. Treatment of AlCl3‐ induced rats with C. erectuse extract ameliorated these selected parameters by variable degrees. In conclusion, C. erectus protects against AlCl3‐ induced AD in rats through its antioxidant, anti‐inflammatory, and antineutron damage. It could be considered as a new nutraceutical agent for attenuating symptoms associated with Alzheimer's disease.

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Does Melatonin Ameliorate Neurological Changes Associated With Alzheimer’s Disease in Ovariectomized Rat Model?

Cited by 13 publications

References 48 publications

Neuroprotective effects of eugenol against aluminiuminduced toxicity in the rat brain

Neuroprotective effects of eugenol against aluminiuminduced toxicity in the rat brain

An insight into the scientific background and future perspectives for the potential uses of melatonin

GC/MS and LC‐ESI‐MS Analysis of Conocarpus erectus Leaves Extract via Regulating Amyloid‐β‐Peptide, Tau Protein, Neurotransmitters, Inflammation and Oxidative Stress against AlCl₃‐Induced Alzheimer's Disease in Rats

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Does Melatonin Ameliorate Neurological Changes Associated With Alzheimer’s Disease in Ovariectomized Rat Model?

Cited by 13 publications

References 48 publications

Neuroprotective effects of eugenol against aluminiuminduced toxicity in the rat brain

Neuroprotective effects of eugenol against aluminiuminduced toxicity in the rat brain

An insight into the scientific background and future perspectives for the potential uses of melatonin

GC/MS and LC‐ESI‐MS Analysis of Conocarpus erectus Leaves Extract via Regulating Amyloid‐β‐Peptide, Tau Protein, Neurotransmitters, Inflammation and Oxidative Stress against AlCl3‐Induced Alzheimer's Disease in Rats

Contact Info

Product

Resources

About

GC/MS and LC‐ESI‐MS Analysis of Conocarpus erectus Leaves Extract via Regulating Amyloid‐β‐Peptide, Tau Protein, Neurotransmitters, Inflammation and Oxidative Stress against AlCl₃‐Induced Alzheimer's Disease in Rats