Does mHealth increase adherence to medication? Results of a systematic review

Anglada-Martínez, Helena; Riu-Viladoms, Gisela; Martin-Conde, Maite; Rovira-Illamola, Marina; Sotoca-Momblona, JM; Codina-Jané, Carles

doi:10.1111/ijcp.12582

Cited by 196 publications

(128 citation statements)

References 47 publications

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“…It is also inherently evident that most of the studies reviewed in this paper were undertaken over shorter periods of time (between 2 years and 4 days). Whereas this is a limitation beyond this paper, it is a calling for longitudinal studies and long term programmatic efforts that would provide more detailed evidence [40][41][42][43][44][45][46][47][48][49][50][51][52].…”

Section: Resultsmentioning

confidence: 99%

Does Message-Based Communication Through Mobile Phones for Medication and Treatment Adherence Improve Health Outcomes? A Systematic Review

Mwangi¹,

Mukanya²

2017

J Pharma Care Health Sys

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Medical non-adherence has been a pervasive issue in healthcare for far too long and consequences of medical non-adherence are far reaching. With the proliferation of mobile technology globally, there have been concerted efforts to improve adherence using mHealth both in developed and developing countries. The objective of this study was to evaluate through previous studies whether mobile phone innovations improve health outcomes through adherence messages to patients and how many of the studies mention and actually consider the content going out to patients as contributing to positive or negative health outcome. A systematic review was conducted using four search engines: PubMed, Mendley, Advanced Google, and Google Scholar. The publications were randomized clinical trials, cross-sectional studies, and pre and post interventional studies. The publications reviewed were considered to be eligible if they were based on use of mobile technology or smart phone applications in improving health outcomes through sending adherence messages. Forty one potential articles were retrieved based on the first search criteria and review of abstracts. Full text was not obtainable for 11 articles due to fees to access the document and/or a registration requirement for the websites making the full text inaccessible. Nine articles were published before the year 2009, 7 were systematic reviews, 1 was an SMS based study but was used by community health workers and did not necessarily address adherence, 3 were protocols for a study to be done, 10 articles met all the inclusion criteria. Mobile health technology has been proven to contribute towards improving adherence to treatment, medication and appointments. However it is crucial to consider the content and its development processes just as much as the technology in use as this might elevate the health outcomes even higher.

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Section: Resultsmentioning

confidence: 99%

Does Message-Based Communication Through Mobile Phones for Medication and Treatment Adherence Improve Health Outcomes? A Systematic Review

Mwangi¹,

Mukanya²

2017

J Pharma Care Health Sys

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“…However, another recent systematic review on the same topic supported its conclusions 3. In contrast, a recent Cochrane Review concluded lack of convincing evidence for beneficial effects of medication reminders; specifically among RCTs with the lowest risk of bias 2.…”

Section: Commentarymentioning

confidence: 98%

Review suggests mobile phone interventions improve medication adherence; rigorous longer term studies are needed to confirm effects

Wark

Car

2015

Evid Based Nurs

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“…With the surge in mobile phone access globally over the past decade, mobile phonebased interventions have been explored in a wide variety of healthcare interventions, with mixed results (Free et al 2013;Anglada-Martinez et al 2014;Vervloet et al 2012). Furthermore, there is a dearth of high-quality trials with adequate power, and most of the trials that have been conducted have been done so in high-income countries (Free et al 2013;Anglada-Martinez et al 2014;Vervloet et al 2012).…”

Section: Introductionmentioning

confidence: 99%

“…Furthermore, there is a dearth of high-quality trials with adequate power, and most of the trials that have been conducted have been done so in high-income countries (Free et al 2013;Anglada-Martinez et al 2014;Vervloet et al 2012). …”

Section: Introductionmentioning

confidence: 99%

Impact of mobile message reminders on tuberculosis treatment outcomes in Pakistan

Mohammed¹,

Glennerster²,

Khan³

2016

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The International Initiative for Impact Evaluation (3ie) is an international grant-making NGO promoting evidence-informed development policies and programmes. We are the global leader in funding, producing and synthesising high-quality evidence of what works, how, why and at what cost. We believe that better and policy-relevant evidence will make development more effective and improve people's lives. 3ie impact evaluations3ie-supported impact evaluations assess the difference a development intervention has made to social and economic outcomes. 3ie is committed to funding rigorous evaluations that include a theory-based design, use the most appropriate mix of methods to capture outcomes and are useful in complex development contexts. About this report3ie accepted the final version of this report, Impact of mobile message reminders on tuberculosis treatment outcomes in Pakistan, as partial fulfilment of requirements under grant OW1.48 issued under Open Window 1. The content has been copy-edited and formatted for publication by 3ie. All of the content is the sole responsibility of the authors and does not represent the opinions of 3ie, its donors or its board of commissioners. Any errors and omissions are the sole responsibility of the authors. Any comments or queries should be directed to the corresponding author, Shama Mohammed at shama@post.harvard.edu SummaryTuberculosis (TB) is the second leading cause of death from infectious disease globally. The treatment is long and results in side effects. Adherence to TB treatment regimens is essential for TB control, as failure to adhere can result in multi-drug-resistant TB. Mobile health offers the opportunity for remote delivery of health. We conducted a randomized controlled trial to gauge the impact of daily two-way SMS reminders on the treatment outcomes of people with drug-susceptible TB in Karachi, Pakistan.We enrolled 2,207 people with drug-susceptible TB into the trial. Once enrolled, mobile phone-based randomization was used to allocate them to either the Zindagi SMS system or a control group that received the standard of care offered by the treating clinic.The Zindagi SMS system was designed to increase adherence to TB treatment. The system is a two-way SMS reminder system in which patients were sent daily SMS messages and were asked to respond via SMS or a missed (unbilled) call to indicate that they had taken their medication. Patients who did not respond for seven days in a row were followed up over the phone. Over the study period, participants who were on the Zindagi SMS system throughout their treatment had a mean response rate of 29 per cent. Response rates started at 48 per cent in the first two weeks in the study and fell to 24 per cent (for participants in the eight month treatment regimen) or 20 per cent (for participants in the six-month treatment regimen). Eighty-five per cent of participants on the Zindagi SMS system responded to the system at least once.The study found no difference in treatment success rate between the Zindagi SMS and contro...

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Does mHealth increase adherence to medication? Results of a systematic review

Cited by 196 publications

References 47 publications

Does Message-Based Communication Through Mobile Phones for Medication and Treatment Adherence Improve Health Outcomes? A Systematic Review

Does Message-Based Communication Through Mobile Phones for Medication and Treatment Adherence Improve Health Outcomes? A Systematic Review

Review suggests mobile phone interventions improve medication adherence; rigorous longer term studies are needed to confirm effects

Impact of mobile message reminders on tuberculosis treatment outcomes in Pakistan

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