Does minocycline, an antibiotic with inhibitory effects on microglial activation, sharpen a sense of trust in social interaction?

Watabe, Motoki; Kato, Takahiro A.; Monji, Akira; Horikawa, Hideki; Kanba, Shigenobu

doi:10.1007/s00213-011-2509-8

Cited by 32 publications

(25 citation statements)

References 36 publications

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“…However, estrogens act on many different ways in the brain and may cause their effect by mechanisms unrelated to inflammation, eg, by affecting angiotensin and dopamine neurotransmission. 75,76 Minocycline is a strong inhibitor of microglia cell activation 24 and may, therefore, be expected to have potent effects on symptom severity. This component was provided in a relatively high dose of 200 mg for a relatively long time (4-12 mo), including 2 studies that restricted inclusion to FEP patients, but the results in these 348 patients were not significant although heterogeneity was high.…”

Section: E Sommer Et Almentioning

confidence: 99%

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Efficacy of Anti-inflammatory Agents to Improve Symptoms in Patients With Schizophrenia: An Update

Sommer

Westrhenen

Begemann

et al. 2013

Schizophrenia Bulletin

306

232

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Section: E Sommer Et Almentioning

confidence: 99%

“…24 Three studies assessed the effect of minocycline addition to antipsychotic treatment. All studies used a relatively high dose of 200 mg and long duration of treatment, ranging from 4 to 12 months.…”

Section: Minocyclinementioning

confidence: 99%

Efficacy of Anti-inflammatory Agents to Improve Symptoms in Patients With Schizophrenia: An Update

Sommer

Westrhenen

Begemann

et al. 2013

Schizophrenia Bulletin

306

232

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show abstract

“…Healthy Japanese adult males made a monetary decision about whether or not to trust an anonymous partner after a 4-day oral administration of minocycline. Our first trial revealed that the minocycline group showed a positive correlation between their monetary score in trust game and their evaluation scores of others’ trustworthiness in a questionnaire (Yamagishi’s General Trust Scale), but surprisingly the placebo group did not (60). It would be rational to consider the monetary and questionnaire score to be positively correlated because both scores measure the other’s trustworthiness, but there was no positive correlation with the placebo group.…”

Section: Possible Glial Roles In Human Mental Functionsmentioning

confidence: 96%

Neuron-Glia Interaction as a Possible Glue to Translate the Mind-Brain Gap: A Novel Multi-Dimensional Approach Toward Psychology and Psychiatry (R1)

2013

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Neurons and synapses have long been the dominant focus of neuroscience, thus the pathophysiology of psychiatric disorders has come to be understood within the neuronal doctrine. However, the majority of cells in the brain are not neurons but glial cells including astrocytes, oligodendrocytes, and microglia. Traditionally, neuroscientists regarded glial functions as simply providing physical support and maintenance for neurons. Thus, in this limited role glia had been long ignored. Recently, glial functions have been gradually investigated, and increasing evidence has suggested that glial cells perform important roles in various brain functions. Digging up the glial functions and further understanding of these crucial cells, and the interaction between neurons and glia may shed new light on clarifying many unknown aspects including the mind-brain gap, and conscious-unconscious relationships. We briefly review the current situation of glial research in the field, and propose a novel translational research with a multi-dimensional model, combining various experimental approaches such as animal studies, in vitro & in vivo neuron-glia studies, a variety of human brain imaging investigations, and psychometric assessments.

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“…Interestingly, we have recently reported that minocycline modulates human social decision-making in healthy volunteers [186,187]. Therefore, minocycline may effect not only on psychiatric patients but also on healthy persons.…”

Section: Minocyclinementioning

confidence: 98%

Neurotransmitters, Psychotropic Drugs and Microglia: Clinical Implications for Psychiatry

Kato¹,

Yamauchi²,

Horikawa³

et al. 2013

Current Medicinal Chemistry

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Psychiatric disorders have long and dominantly been regarded to be induced by disturbances of neuronal networks including synapses and neurotransmitters. Thus, the effects of psychotropic drugs such as antipsychotics and antidepressants have been understood to modulate synaptic regulation via receptors and transporters of neurotransmitters such as dopamine and serotonin. Recently, microglia, immunological/inflammatory cells in the brain, have been indicated to have positive links to psychiatric disorders. Positron emission tomography (PET) imaging and postmortem studies have revealed microglial activation in the brain of neuropsychiatric disorders such as schizophrenia, depression and autism. Animal models of neuropsychiatric disorders have revealed the underlying microglial pathologies. In addition, various psychotropic drugs have been suggested to have direct effects on microglia. Until now, the relationship between microglia, neurotransmitters and psychiatric disorders has not been well understood. Therefore, in this review, at first, we summarize recent findings of interaction between microglia and neurotransmitters such as dopamine, serotonin, norepinephrine, acetylcholine and glutamate. Next, we introduce up-to-date knowledge of the effects of psychotropic drugs such as antipsychotics, antidepressants and antiepileptics on microglial modulation. Finally, we propose the possibility that modulating microglia may be a key target in the treatment of various psychiatric disorders. Further investigations and clinical trials should be conducted to clarify this perspective, using animal in vivo studies and imaging studies with human subjects.

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Does minocycline, an antibiotic with inhibitory effects on microglial activation, sharpen a sense of trust in social interaction?

Cited by 32 publications

References 36 publications

Efficacy of Anti-inflammatory Agents to Improve Symptoms in Patients With Schizophrenia: An Update

Efficacy of Anti-inflammatory Agents to Improve Symptoms in Patients With Schizophrenia: An Update

Neuron-Glia Interaction as a Possible Glue to Translate the Mind-Brain Gap: A Novel Multi-Dimensional Approach Toward Psychology and Psychiatry (R1)

Neurotransmitters, Psychotropic Drugs and Microglia: Clinical Implications for Psychiatry

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