Does nebivolol have renoprotective action in patients with chronic kidney disease conditions? An integrative review

Encinas, Jessica; Peiró, Carlos Henrique Foncesca; Perez, Matheus Moreira; Raimundo, Joyce Regina Santos; Gois, Katharyna Cardoso de; Peres, Marina Cristina; Draghi, Patricia Ferrante; Arcia, Catherine Giovanna Costas; Simões, Diogo Pimenta; Murad, Neif; Alves, Beatriz da Costa Aguiar; Fonseca, Fernando Luiz Affonso; Veiga, Gláucia Luciano da

doi:10.1016/j.ejphar.2021.174180

Cited by 3 publications

(3 citation statements)

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“…TDF+NBV group presented a normalization of MAP, which was accompanied by a decrease in both plasma and tissue concentrations of AngII and plasma Aldo levels. AngII, one of the main components of the RAAS, is a potent systemic vasoconstrictor responsible for Aldo secretion and the arising of hypertension, promoting renal mass loss and worsening of CKD ( 28 – 30 ). Blumenfeld et al stated that β-adrenergic receptor blockers are frequently neglected as potent suppressors of renin secretion and, consequently, AngII formation.…”

Section: Discussionmentioning

confidence: 99%

Treatment with β-blocker nebivolol ameliorates oxidative stress and endothelial dysfunction in tenofovir-induced nephrotoxicity in rats

et al. 2022

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BackgroundTenofovir disoproxil fumarate (TDF), a widely prescribed component in antiretroviral regimens, has been associated with nephrotoxicity. Nebivolol is a third generation selective β-1 adrenergic receptor blocker and may protect renal structure and function through the suppression of oxidative stress and enhancement of nitric oxide (NO) synthesis. We aimed to investigate whether nebivolol could be an effective therapeutic strategy to mitigate tenofovir-induced nephrotoxicity.MethodsWe allocated Wistar rats to four groups: control (C), received a standard diet for 30 days; NBV, received a standard diet for 30 days added with nebivolol (100 mg/kg food) in the last 15 days; TDF, received a standard diet added with tenofovir (300 mg/kg food) for 30 days; and TDF+NBV, received a standard diet added with tenofovir for 30 days and nebivolol in the last 15 days.ResultsLong-term exposure to tenofovir led to impaired renal function, induced hypertension, endothelial dysfunction and oxidative stress. Nebivolol treatment partially recovered glomerular filtration rate, improved renal injury, normalized blood pressure and attenuated renal vasoconstriction. Administration of nebivolol contributed to reductions in asymmetric dimethylarginine (ADMA) levels as well as increases in endothelial nitric oxide sintase (eNOS) accompanied by renin-angiotensin-aldosterone system downregulation and decreases in macrophage and T-cells infiltrate. Furthermore, nebivolol was responsible for the maintenance of the adequate balance of thiobarbituric acid reactive substances (TBARS) and glutathione (GSH) levels and it was associated with reductions in NADPH oxidase (NOX) subunits.ConclusionNebivolol holds multifaceted actions that promote an advantageous option to slow the progression of kidney injury in tenofovir-induced nephrotoxicity.

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Section: Discussionmentioning

confidence: 99%

Treatment with β-blocker nebivolol ameliorates oxidative stress and endothelial dysfunction in tenofovir-induced nephrotoxicity in rats

et al. 2022

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“…O néfron possui todos os componentes do SRAA: o angiotensinogênio (AGT) sintetizado no túbulo proximal, a renina produzida pelo aparelho justaglomerular e túbulo distal, a enzima conversora de angiotensina (ECA) e os receptores de angiotensina II localizados ao longo do néfron [63]. A angiotensina II é um potente vasoconstritor sistêmico que eleva os níveis da PAM, promovendo a destruição de néfrons e, consequentemente, perda de massa renal e piora da DRC [64]. Apesar da secreção renal de renina ser o regulador da formação de angiotensina II, este componente promove diretamente a vasoconstrição e a secreção de aldosterona através da sua ligação com os receptores do tipo 1 de angiotensina II (AT-1) [22].…”

Section: Discussionunclassified

“…Esses resultados sugerem que a ADMA é um marcador de disfunção endotelial importante e que, possivelmente, a sua diminuição foi responsável pela normalização da expressão proteica de eNOS nos animais do grupo TDF+NBV. A combinação dos efeitos benéficos do nebivolol nas vias do SRAA e do NO resulta em uma proteção cardiovascular [64] e renal e pode justificar a sua eficiência na redução da PAM e na melhora dos parâmetros hemodinâmicos observados em nossos animais do grupo TDF+NBV. Vale ressaltar que a indução da produção de NO é independente do bloqueio dos receptores adrenérgicos β1 e esta característica é específica do nebivolol [42].…”

Section: Discussionunclassified

Avaliação dos efeitos do Nebivolol sobre a nefrotoxicidade em ratos tratados com Tenofovir

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Tenofovir disoproxil fumarate (TDF), a widely prescribed component in antiretroviral regimens, has been associated with nephrotoxicity. Nebivolol is a third generation selective β-1 adrenergic receptor blocker and may protect renal structure and function through the suppression of oxidative stress and enhancement of nitric oxide (NO) synthesis. We aimed to investigate whether treatment with nebivolol could be an effective therapeutic strategy to mitigate tenofovir-induced nephrotoxicity. We allocated Wistar rats to four groups: 1-control (C), received a standard diet (SD) for 30 days; 2-NBV, received a SD for 30 days then the same SD diet added with nebivolol (100 mg/kg SD) in the last 15 days; 3-TDF, received a SD added with tenofovir (300 mg/kg SD) for 30 days; and 4-TDF+NBV, received the same SD described above added with tenofovir for 30 days and nebivolol in the last 15 days. Long-term exposure to tenofovir led to impaired renal function, induced hypertension, endothelial dysfunction and oxidative stress. Nebivolol treatment partially recovered glomerular filtration rate, normalized blood pressure and attenuated renal vasoconstriction and renal injury. Administration of nebivolol contributed to reductions in asymmetric dimethylarginine (ADMA) levels as well as increases in endothelial nitric oxide sintase (eNOS) accompanied by reninangiotensin-aldosterone system downregulation and decreases in macrophage and Tcells infiltrate. Furthermore, nebivolol was responsible for the maintenance of the adequate balance of thiobarbituric acid reactive substances (TBARS) and glutathione (GSH) levels and it was associated with reductions in NADPH oxidase (NOX) subunits.Nebivolol holds multifaceted actions that promote an advantageous option to slow the progression of kidney injury in tenofovir-induced nephrotoxicity.

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Antihypertensive and cardioprotective effects of three generations of beta-adrenergic blockers: an historical perspective

Chrysant

2022

Hospital Practice

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Does nebivolol have renoprotective action in patients with chronic kidney disease conditions? An integrative review

Cited by 3 publications

References 36 publications

Treatment with β-blocker nebivolol ameliorates oxidative stress and endothelial dysfunction in tenofovir-induced nephrotoxicity in rats

Treatment with β-blocker nebivolol ameliorates oxidative stress and endothelial dysfunction in tenofovir-induced nephrotoxicity in rats

Avaliação dos efeitos do Nebivolol sobre a nefrotoxicidade em ratos tratados com Tenofovir

Antihypertensive and cardioprotective effects of three generations of beta-adrenergic blockers: an historical perspective

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